Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.898955
Keywords
paeoniflorin; brain; neuroinflammation; oxidative stress; neuroprotection
Categories
Funding
- Science and Technology Project of Nantong City
- Postgraduate Research and Practice Innovation Program of Jiangsu Province
- Natural Science Foundation of the Higher Education Institutions of Jiangsu Province
- [JC2020013]
- [JC2020020]
- [KYCX21_3107]
- [20KJB310025]
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Paeoniflorin, a compound extracted from Paeonia lactiflora Pall, has shown preventive and therapeutic effects in various types of nervous system disorders. However, comprehensive knowledge about the pharmacological effects of paeoniflorin on the nervous system is currently not available online. This review summarizes the pharmacological aspects of paeoniflorin and its possible mechanisms, highlighting its potential in the prevention and treatment of disorders like cerebral ischemia, subarachnoid hemorrhage, vascular dementia, Alzheimer's disease, Parkinson's disease, depression, post-traumatic syndrome disorder, and epilepsy.
Paeoniflorin, a terpenoid glycoside compound extracted from Paeonia lactiflora Pall, shows preventive and therapeutic effects in various types of nervous system disorders. However, to date, no comprehensive knowledge on the pharmacological effects of paeoniflorin on the nervous system is available online. Clarification of this issue may be useful for the development of paeoniflorin as a new drug for the treatment of nervous system disorders. To this end, the authors summarize the pharmacological aspects of paeoniflorin and its possible mechanisms, such as restoration of mitochondrial function; inhibition of neuroinflammation, oxidative stress, and cellular apoptosis; activation of adenosine A1 receptor, cAMP response element-binding protein (CREB) and extracellular signal-regulated kinase 1/2 (ERK1/2); or enhancement of brain-derived neurotrophic factor and serotonin function, in the prevention of disorders such as cerebral ischemia, subarachnoid hemorrhage, vascular dementia, Alzheimer's disease, Parkinson's disease, depression, post-traumatic syndrome disorder, and epilepsy, by reviewing the previously published literature.
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