Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.917266
Keywords
anti-aging; antioxidant; biological effect; urolithin B; nutritional agent
Categories
Funding
- National Natural Science Foundation of China [31770381]
- Scientific Research Fund of Wuhan Municipal Health Commission [WZ20D07]
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Uro B is a natural compound produced by gut bacteria with strong antioxidant and anti-inflammatory properties, which can prevent the development of hyperlipidemia, cardiovascular disease, and tumors. Despite the limited availability of reviews on Uro B, it has significant pharmacological activity and preventive potential as a nutritional agent in humans.
Urolithin (Uro) B is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranates, raspberries, blueberries and chestnuts. Uro B has recently garnered considerable attention owing to its wide range of nutraceutical effects and relatively high potency. According to several studies, Uro B prevents the development of hyperlipidemia, cardiovascular disease (CVD) and tumors due to its strong antioxidant and anti-inflammatory properties. Many reviews have systematically summarized the health benefits and pharmacological activities of ETs, EA and urolithins (especially Uro A) while available reviews or detailed summaries on the positive impact of Uro B are rarer. Here, we sought to review the pharmacological activity, mechanism of action, regulation of immune function and its associated diseases and preventive potential of Uro B to elucidate its function as a nutritional agent in humans.
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