4.7 Review

Role of ferroptosis and ferroptosis-related non-coding RNAs in the occurrence and development of gastric cancer

Related references

Note: Only part of the references are listed.
Article Oncology

3,3′-Diindolylmethane induces ferroptosis by BAP1-IP3R axis in BGC-823 gastric cancer cells

Yang Ye et al.

Summary: The study investigated the effect of 3,3'-diindolylmethane (DIM) on ferroptosis against gastric cancer and found that DIM could induce ferroptosis in BGC-823 gastric cancer cells by upregulating lipid-ROS levels and decreasing GSH generation. DIM also reduced the protein levels of SLC7A11 and GPX4 while increasing BAP1 and IP3R levels. The findings suggest that DIM exerts anti-cancer effects through the BAP1-IP3R axis and has therapeutic potential in gastric cancer.

ANTI-CANCER DRUGS (2022)

Article Biochemistry & Molecular Biology

The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination

Guoquan Huang et al.

Summary: This study found that BDNF-AS is highly expressed in gastric cancer and peritoneal metastasis tissues, and its overexpression is associated with gastric cancer progression and poor prognosis. BDNF-AS overexpression protects gastric cancer cells from ferroptosis and promotes the progression of gastric cancer and peritoneal metastasis. Mechanistically, BDNF-AS regulates the transcription of FBXW7 by recruiting WDR5, thus affecting the ubiquitination of VDAC3.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Article Cell Biology

Ferroptosis-related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma

Ruoxi Xiao et al.

Summary: This study identified a ferroptosis-related gene prognostic signature for stomach adenocarcinoma (STAD) and validated its reliability in predicting patient outcomes. The study also found that the signature has relevance to immune characteristics and may improve the efficacy of personalized immunotherapy.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Review Biochemistry & Molecular Biology

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

Chen Zhang et al.

Summary: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in tumor suppression and has the potential to reverse cancer therapy resistance.

MOLECULAR CANCER (2022)

Article Oncology

Ferroptosis-related long non-coding RNAs and the roles of LASTR in stomach adenocarcinoma

Gongjun Wang et al.

Summary: This study identified differentially expressed lncRNAs associated with overall survival and progression-free survival in stomach adenocarcinoma (STAD). Two signatures based on these lncRNAs were established to predict the prognosis of STAD. Furthermore, the study confirmed the role of lncRNA LASTR in gastric cancer and explored its relationship with ferroptosis. These findings provide potential targets for tumor treatment and contribute to personalized medicine.

MOLECULAR MEDICINE REPORTS (2022)

Article Cell Biology

Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2'-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester

Deng Guan et al.

Summary: Research revealed that DpdtbA resisted TGF-beta 1-induced EMT through ferritinophagy-mediated ROS production, promoting EMT inhibition. Additionally, activation of Nrf2 played a role in regulating the cellular redox environment changes.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Article Oncology

Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT-dependent ferroptosis pathway

Liyi Zhang et al.

Summary: This study found that Ophiopogonin B (OP-B) suppresses gastric cancer cell viability and induces ferroptosis by blocking the GPX4/xCT system.

ONCOLOGY LETTERS (2022)

Article Multidisciplinary Sciences

EBV miRNAs BART11 and BART17-3p promote immune escape through the enhancer-mediated transcription of PD-L1

Jie Wang et al.

Summary: This study finds that EBV-miR-BART11 and EBV-miR-BART17-3p upregulate the expression of PD-L1 in EBV-associated cancers and elucidates the underlying regulatory mechanism, promoting tumor immune escape and providing potential targets for EBV-related tumor immunotherapy.

NATURE COMMUNICATIONS (2022)

Article Genetics & Heredity

Prognostic Ferroptosis-Related lncRNA Signatures Associated With Immunotherapy and Chemotherapy Responses in Patients With Stomach Cancer

Donlin Lai et al.

Summary: This study investigates the combined effects of ferroptosis and lncRNAs on the prognosis and therapy of stomach cancer. A prognostic model consisting of 10 ferroptosis-related lncRNAs was constructed and validated. The model had guiding significance for prognosis and personalized therapy, helping to identify stomach cancer patients who might benefit from immunotherapy and guiding the selection of personalized chemotherapeutic drugs. The study also revealed differences in immune response and sensitivity to certain chemotherapy drugs among different risk groups.

FRONTIERS IN GENETICS (2022)

Article Oncology

Network Pharmacology Study and Experimental Validation of Yiqi Huayu Decoction Inducing Ferroptosis in Gastric Cancer

Siyuan Song et al.

Summary: This study identified the mechanism by which Yiqi Huayu Decoction (YQHY) induces ferroptosis in gastric cancer (GC) using network pharmacology and experimental validation. The results showed that YQHY can induce ferroptosis in GC by affecting the JAK2-STAT3 pathway and the expression of ACSL4. This induction of ferroptosis may be one of the possible mechanisms of YQHY's anti-recurrence and metastasis of GC.

FRONTIERS IN ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

From DNMT1 degrader to ferroptosis promoter: Drug repositioning of 6-Thioguanine as a ferroptosis inducer in gastric cancer

Jinping Zhang et al.

Summary: The compound 6-TG was identified as a potential ferroptosis inducer in gastric cancer cells, showing anti-tumor activity by triggering iron-mediated ferroptosis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer

Mingzhe Ma et al.

Summary: This study identified a link between methionine cycle activity and susceptibility to ferroptosis, and discovered the role of MAT2A in ferroptosis resistance.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Article Genetics & Heredity

Establishment and Validation of a Ferroptosis-Related Long Non-Coding RNA Signature for Predicting the Prognosis of Stomach Adenocarcinoma

Shuqiong Zhang et al.

Summary: We identified a three-ferroptosis-related-lncRNA signature (AP000695.2, AL365181.3, and LINC01615) that can predict the prognosis of STAD patients. The GSEA indicated that these three ferroptosis-related lncRNAs might be related to the extracellular matrix and cellular activities.

FRONTIERS IN GENETICS (2022)

Review Oncology

Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

Yue Zhang et al.

Summary: This review provides a detailed overview of the classification, characteristics, biogenesis, functions, and latest advances in cancer research of circular RNAs (circRNAs). The unique features of circRNAs, such as their high abundance, strong specificity, and good stability, have been identified, and their various functions and mechanisms in biological events, including cancer occurrence and development, have been extensively studied. The development of circRNAs as biomarkers in cancer diagnosis and treatment also opens up new avenues for circRNA research.

FRONTIERS IN ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer

Shunv Cai et al.

Summary: This study found that silencing SIRT6 can overcome sorafenib resistance in gastric cancer by promoting ferroptosis. Mechanistically, SIRT6 inhibition leads to inactivation of the Keap1/Nrf2 pathway and downregulation of GPX4, while over-expression of GPX4 or activation of Keap1/Nrf2 can reverse the effects. Targeting the SIRT6/Keap1/Nrf2/GPX 4 pathway may be a potential strategy for overcoming sorafenib resistance in gastric cancer.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Oncology

A novel ferroptosis-related lncRNA signature for prognosis prediction in gastric cancer

Jianming Wei et al.

Summary: In this study, a prognostic ferroptosis-related lncRNA signature was constructed for gastric cancer, with the low-risk group showing significantly better prognosis than the high-risk group. The risk score was identified as an independent prognostic factor. This risk model provides a novel method for predicting prognosis in gastric cancer patients.

BMC CANCER (2021)

Article Biotechnology & Applied Microbiology

A Novel Ferroptosis-Related Gene Risk Signature for Predicting Prognosis and Immunotherapy Response in Gastric Cancer

Shi-jin Liu et al.

Summary: The study reveals the important role of ferroptosis-related genes in the pathogenesis of gastric cancer. Patients with high FRGScore have worse prognosis, and the constructed prognostic model shows superior accuracy. FRG RiskScore can act as an independent biomarker for the prognosis of GC patients.

DISEASE MARKERS (2021)

Article Oncology

Apatinib induced ferroptosis by lipid peroxidation in gastric cancer

Liying Zhao et al.

Summary: In summary, apatinib induces lipid peroxidation through GPX4 mediated by SREBP-1a, leading to the ferroptosis of gastric cancer cells, including multi-drug resistant ones.

GASTRIC CANCER (2021)

Article Cell Biology

Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer

Yanfei Shao et al.

Summary: The study constructed a prognostic signature of 10 ferroptosis-related genes, which effectively predict the survival rate and immunotherapy response of gastric cancer patients. By screening differentially expressed genes and dividing patients into high-risk and low-risk groups based on risk scores, it was found that patients in the low-risk group had better survival possibilities.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Cell Biology

Chemotoxicity-induced exosomal lncFERO regulates ferroptosis and stemness in gastric cancer stem cells

Haiyang Zhang et al.

Summary: Cancer stem cells are influenced by ferroptosis, a form of cell death involving iron ions and regulated by intracellular signals. The role of ferroptosis in tumor stem cells is crucial for understanding mechanisms of recurrence and drug resistance in cancers.

CELL DEATH & DISEASE (2021)

Review Cell Biology

Progress in understanding the role of lncRNA in programmed cell death

Na Jiang et al.

Summary: Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides that regulate gene expressions at various levels. Studies have shown that lncRNAs are closely related to programmed cell death (PCD) and play important roles in various cancers.

CELL DEATH DISCOVERY (2021)

Article Biotechnology & Applied Microbiology

Development and Validation of a Novel Ferroptosis-Related Gene Signature for Predicting Prognosis and the Immune Microenvironment in Gastric Cancer

Feng Wang et al.

Summary: A novel FRG signature was established in this study to predict GC prognosis and reflect the status of the tumor immune microenvironment.

BIOMED RESEARCH INTERNATIONAL (2021)

Review Biochemical Research Methods

Non-coding RNA in cancer

Huiwen Yan et al.

Summary: The majority of the human genome is transcribed into non-coding RNAs (ncRNAs) that play crucial roles in regulating cancer initiation and progression. This review focuses on recent studies of the function, regulatory mechanisms, and therapeutic potential of ncRNAs such as microRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA), and PIWI interacting RNA (piRNA) in various types of cancers.

NON-CODING GENOME (2021)

Article Oncology

The Ferroptosis-Related Noncoding RNA Signature as a Novel Prognostic Biomarker in the Tumor Microenvironment, Immunotherapy, and Drug Screening of Gastric Adenocarcinoma

Xinming Chen et al.

Summary: The study identified a carcinogenic risk signature using ferroptosis-related ncRNAs for predicting prognoses of gastric adenocarcinoma patients. Patients in the high-risk group had higher immune cell recruitment, and the overall effect of anti-immune checkpoint immunotherapy was not as effective as in the low-risk group. High- and low-risk groups were enriched in tumor- and immune-related pathways, respectively.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p/STAT3 axis

Yi-Ping Liu et al.

Summary: The study revealed that propofol inhibits proliferation, induces apoptosis, suppresses invasion and migration of gastric cancer cells. It induces ferroptosis by regulating the miR-125b-5p/STAT3 axis, suggesting its potential as a therapeutic candidate for gastric cancer.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

Article Cell Biology

Expression of Ferroptosis-Related Genes Shapes Tumor Microenvironment and Pharmacological Profile in Gastric Cancer

Shilang Xiao et al.

Summary: This study revealed that by varying the activation degrees of ferroptosis, tumor cells and their surrounding microenvironment could be shaped. Establishing ferroptosis-related subtypes would guide in predicting the biological features of individual tumors and selecting appropriate treatment protocols for patients.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cell Biology

LncRNAs Target Ferroptosis-Related Genes and Impair Activation of CD4+ T Cell in Gastric Cancer

Fuwen Yao et al.

Summary: The study showed that high expression of hub FRGs in gastric cancer is associated with poor overall survival in patients, with CD4(+) T cells being the major infiltrated cells in the tumor microenvironment. Furthermore, the hub FRGs are significantly correlated with activated CD4(+) T cell infiltration, suggesting their potential role in mediating CD4(+) T cell activation through various signaling pathways.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cell Biology

A Ferroptosis-Related lncRNAs Signature Predicts Prognosis and Therapeutic Response of Gastric Cancer

Shilang Xiao et al.

Summary: This study systematically evaluated the role of ferroptosis-related lncRNAs in GC, and found that risk stratification could reflect the biological characteristics and treatment response of GC patients. The ferroptosis-related lncRNA signature could serve as a reliable biomarker for predicting the prognosis and therapeutic response of GC patients.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Nutrition & Dietetics

Characterization of Two Ferroptosis Subtypes With Distinct Immune Infiltration and Gender Difference in Gastric Cancer

Junfu Ma et al.

Summary: The study identified two distinct ferroptosis subtypes in gastric cancer and revealed marked differences in sex hormone receptors and immune cell infiltration. Gender differences may play a critical role in the application of ferroptosis-related strategies in gastric cancer treatment. Patients with low-ferroptosis scores showed increased immune response, better response to immunotherapy, and lower estimated IC50 in several chemotherapy drugs.

FRONTIERS IN NUTRITION (2021)

Article Medicine, General & Internal

Ferroptosis Patterns Correlate with Immune Microenvironment Characterization in Gastric Cancer

Xiaotao Jiang et al.

Summary: Our study established two ferroptosis subtypes in gastric cancers, with C2 showing higher FSS and lower FPI compared to C1. These subtypes were associated with different TME characteristics, with C2 displaying an immune-excluded phenotype and C1 linked to an immune-inflamed phenotype. The assessment of ferroptosis patterns and levels may provide valuable insights for the development of targeted immunotherapeutic strategies for GC patients.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

Article Pharmacology & Pharmacy

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer

Ying Liu et al.

Summary: The new JDA derivative a2 was found to inhibit the growth of gastric cancer cells and induce ferroptosis. Through the autophagy pathway, a2 caused ferrous iron accumulation, and prevention of this process alleviated a2-induced elevation of ferrous iron and cell growth inhibition, demonstrating stronger anti-cancer activity in gastric cancer xenograft models compared to 5-fluorouracil.

ACTA PHARMACEUTICA SINICA B (2021)

Article Biochemistry & Molecular Biology

Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling

Dazhi Fu et al.

Summary: The study revealed that upregulation of ATF3 in gastric carcinoma cells can sensitize them to cisplatin chemotherapy by inducing ferroptosis and inhibiting Nrf2/Keap1/xCT signaling pathway. This suggests a potential therapeutic approach for overcoming chemoresistance in advanced gastric carcinoma.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2021)

Article Biotechnology & Applied Microbiology

Identification of Ferroptosis-Related Long Noncoding RNA and Construction of a Novel Prognostic Signature for Gastric Cancer

WenZheng Chen et al.

Summary: The study identified 20 ferroptosis-related lncRNAs and constructed a prognostic signature to classify gastric cancer patients into high-risk and low-risk groups. The signature was an independent prognostic indicator of survival and associated with immune cell infiltration, potentially aiding in personalized prognoses and treatments for gastric cancer patients.

DISEASE MARKERS (2021)

Article Biochemistry & Molecular Biology

CPEB1 enhances erastin-induced ferroptosis in gastric cancer cells by suppressing twist1 expression

Jing Wang et al.

Summary: In this study, it was found that CPEB1 promotes erastin-induced ferroptosis by inhibiting twist1. Overexpression of CPEB1 makes GC cells more sensitive to erastin, while silencing CPEB1 makes cells more resistant. This demonstrates the importance of CPEB1 in regulating ferroptosis in gastric cancer.

IUBMB LIFE (2021)

Review Biochemistry & Molecular Biology

Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications

Xiao-Huan Tang et al.

Summary: Exosomes, a subpopulation of the tumour microenvironment (TME), are crucial for intercellular communication and are enriched with noncoding RNAs that play important roles in the tumorigenesis, progression, and drug resistance of gastric cancer (GC). Regulating exosomal ncRNAs levels could potentially serve as therapeutic targets for GC treatment.

MOLECULAR CANCER (2021)

Article Genetics & Heredity

Eight-gene prognostic signature associated with hypoxia and ferroptosis for gastric cancer with general applicability

Junyu Huo et al.

Summary: The risk score established using hypoxia- and ferroptosis-related genes showed good performance in predicting overall survival and relapse-free survival in gastric cancer patients. This eight-gene signature may improve the prognostic risk classification of gastric cancer.

EPIGENOMICS (2021)

Article Cell & Tissue Engineering

MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis

Haiwei Ni et al.

Summary: The study revealed that miR-375 can reduce the stemness of gastric cancer cells by targeting SLC7A11 and triggering ferroptosis. The miR-375/SLC7A11 regulatory axis may serve as a potential therapeutic target to attenuate the stemness of gastric cancer cells.

STEM CELL RESEARCH & THERAPY (2021)

Article Pharmacology & Pharmacy

Levobupivacaine Induces Ferroptosis by miR-489-3p/SLC7A11 Signaling in Gastric Cancer

Shun-Hong Mao et al.

Summary: Levobupivacaine induces ferroptosis of gastric cancer cells to repress cell growth by regulating the miR-489-3p/SLC7A11 axis.

FRONTIERS IN PHARMACOLOGY (2021)

Review Genetics & Heredity

Roles of ncRNAs as ceRNAs in Gastric Cancer

Junhong Ye et al.

Summary: Significant progress has been made in the field of non-coding RNAs, with a focus on miRNAs, lncRNAs, circRNAs, and their roles in diseases like cancer. In gastric cancer research, the complex ceRNA crosstalk mechanism has provided new insights into the disease and potential therapeutic targets.

GENES (2021)

Article Genetics & Heredity

Construction on of a Ferroptosis-Related lncRNA-Based Model to Improve the Prognostic Evaluation of Gastric Cancer Patients Based on Bioinformatics

Jiahui Pan et al.

Summary: By analyzing ferroptosis-related lncRNAs, a gastric cancer prognostic signature model including 17 lncRNAs was constructed by the research team, improving survival prediction for gastric cancer patients. The model showed good predictive ability in prognosis evaluation.

FRONTIERS IN GENETICS (2021)

Article Biochemistry & Molecular Biology

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

Haiyang Zhang et al.

MOLECULAR CANCER (2020)

Review Biochemistry & Molecular Biology

Noncoding RNAs in gastric cancer: implications for drug resistance

Ling Wei et al.

MOLECULAR CANCER (2020)

Article Biochemistry & Molecular Biology

Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down

Zhenhua Guan et al.

BIOSCIENCE REPORTS (2020)

Review Oncology

Non-coding RNA in bladder cancer

Yi Li et al.

CANCER LETTERS (2020)

Article Multidisciplinary Sciences

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer

Ji-Yoon Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers

Ahmed Gomaa et al.

SCIENTIFIC REPORTS (2019)

Review Oncology

Non-coding RNA in drug resistance of gastric cancer

Ya-Jun Luo et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2019)