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Summary: In summary, apatinib induces lipid peroxidation through GPX4 mediated by SREBP-1a, leading to the ferroptosis of gastric cancer cells, including multi-drug resistant ones.
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Yanfei Shao et al.
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Fuwen Yao et al.
Summary: The study showed that high expression of hub FRGs in gastric cancer is associated with poor overall survival in patients, with CD4(+) T cells being the major infiltrated cells in the tumor microenvironment. Furthermore, the hub FRGs are significantly correlated with activated CD4(+) T cell infiltration, suggesting their potential role in mediating CD4(+) T cell activation through various signaling pathways.
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Shilang Xiao et al.
Summary: This study systematically evaluated the role of ferroptosis-related lncRNAs in GC, and found that risk stratification could reflect the biological characteristics and treatment response of GC patients. The ferroptosis-related lncRNA signature could serve as a reliable biomarker for predicting the prognosis and therapeutic response of GC patients.
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Junfu Ma et al.
Summary: The study identified two distinct ferroptosis subtypes in gastric cancer and revealed marked differences in sex hormone receptors and immune cell infiltration. Gender differences may play a critical role in the application of ferroptosis-related strategies in gastric cancer treatment. Patients with low-ferroptosis scores showed increased immune response, better response to immunotherapy, and lower estimated IC50 in several chemotherapy drugs.
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Xiaotao Jiang et al.
Summary: Our study established two ferroptosis subtypes in gastric cancers, with C2 showing higher FSS and lower FPI compared to C1. These subtypes were associated with different TME characteristics, with C2 displaying an immune-excluded phenotype and C1 linked to an immune-inflamed phenotype. The assessment of ferroptosis patterns and levels may provide valuable insights for the development of targeted immunotherapeutic strategies for GC patients.
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Ying Liu et al.
Summary: The new JDA derivative a2 was found to inhibit the growth of gastric cancer cells and induce ferroptosis. Through the autophagy pathway, a2 caused ferrous iron accumulation, and prevention of this process alleviated a2-induced elevation of ferrous iron and cell growth inhibition, demonstrating stronger anti-cancer activity in gastric cancer xenograft models compared to 5-fluorouracil.
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Jing Wang et al.
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Summary: Exosomes, a subpopulation of the tumour microenvironment (TME), are crucial for intercellular communication and are enriched with noncoding RNAs that play important roles in the tumorigenesis, progression, and drug resistance of gastric cancer (GC). Regulating exosomal ncRNAs levels could potentially serve as therapeutic targets for GC treatment.
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