Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.902302
Keywords
gastric cancer; ferroptosis; noncoding RNA; mechanisms; function
Categories
Funding
- National Natural Science Foundation of China [81602883]
- project of social development in Zhenjiang [SH2021045]
- Jinshan Doctor medical field talent training plan of Zhenjiang
- Foundation for Excellent Young Teachers of Jiangsu University
- Clinical Medical Science and Technology Development Foundation of Jiangsu University [JLY2021013]
- Second Affiliated Hospital of Anhui Medical University [LHJJ202003]
- Center for Medical Physics, Chinese Academy of Sciences [LHJJ202003]
- Suzhou Science and Technology Town Hospital Pre-Research Fund [szkjcyy2022002]
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This article summarizes the roles and functions of ferroptosis and ferroptosis-related ncRNAs in the tumorigenesis, development, and prognosis of gastric cancer (GC) and prospects the future research direction and challenges.
Gastric cancer (GC) is a malignant cancer of the digestive tract and is a life-threatening disease worldwide. Ferroptosis is a newly discovered form of regulated cell death, which involves the accumulation of iron-dependent lipid peroxides. It has been found that ferroptosis plays an important regulatory role in the occurrence, development, drug resistance, and prognosis of GC. Non-coding RNAs (ncRNAs) play a critical role in the occurrence and progression of a variety of diseases including GC. In recent years, the role of ferroptosis and ferroptosis-related ncRNAs (miRNA, lncRNA, and circRNA) in the occurrence, development, drug resistance, and prognosis of GC has attracted more and more attention. Herein, we briefly summarize the roles and functions of ferroptosis and ferroptosis-related ncRNAs in GC tumorigenesis, development, and prognosis. We also prospected the future research direction and challenges of ferroptosis and ferroptosis-related ncRNAs in GC.
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