4.5 Review

Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage

Journal

FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 15, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2022.927334

Keywords

intracerebral hemorrhage; brain edema; deferoxamine; iron overload; neuronal death

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Funding

  1. National Key Research and Development Program of China [2018YFC1312200]
  2. National Natural Science Foundation of China [82071331, 81870942, 81520108011]
  3. China Postdoctoral Science Foundation [2020TQ0289, 2020M672291]
  4. Canadian Institutes of Health Sciences

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This review summarizes recent progress in understanding the mechanisms by which deferoxamine may alleviate intracerebral hemorrhage (ICH) and discusses the potential clinical utility of deferoxamine.
Intracerebral hemorrhage (ICH) is a subtype of stroke that is characterized by high morbidity and mortality, for which clinical outcome remains poor. An extensive literature indicates that the release of ferrous iron from ruptured erythrocytes in the hematoma is a key pathogenic factor in ICH-induced brain injury. Deferoxamine is an FDA-approved iron chelator that has the capacity to penetrate the blood-brain barrier after systemic administration and binds to iron. Previous animal studies have shown that deferoxamine attenuates ICH-induced brain edema, neuronal death, and neurological deficits. This review summarizes recent progress of the mechanisms by which deferoxamine may alleviate ICH and discusses further studies on its clinical utility.

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