Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2022.907064
Keywords
glia; glia-neuron interaction; olfaction; calcium channel; adaptation
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Funding
- Innovation 2030 Major Project of the Ministry of Science and Technology of China [2021ZD0203300]
- National Foundation of Natural Science of China [31771113, 31471023, 31800878, 31900736]
- Zhejiang Provincial Natural Science Foundation [LZ22C090001]
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The glial L-Type VGCC EGL-19 plays a crucial role in regulating calcium variations and behavioral outputs in C. elegans, and it also affects the morphologies of sensory neurons and glial cells.
Calcium channelopathies have been strongly linked to cardiovascular, muscular, neurological and psychiatric disorders. The voltage-gated calcium channels (VGCC) are vital transducers of membrane potential changes to facilitate the dynamics of calcium ions and release of neurotransmitter. Whether these channels function in the glial cell to mediate calcium variations and regulate behavioral outputs, is poorly understood. Our results showed that odorant and mechanical stimuli evoked robust calcium increases in the amphid sheath (AMsh) glia from C. elegans, which were largely dependent on the L-Type VGCC EGL-19. Moreover, EGL-19 modulates the morphologies of both ASH sensory neurons and AMsh glia. Tissue-specific knock-down of EGL-19 in AMsh glia regulated sensory adaptability of ASH neurons and promoted olfactory adaptation. Our results reveal a novel role of glial L-Type VGCC EGL-19 on olfaction, lead to improved understanding of the functions of VGCCs in sensory transduction.
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