☆ 4.5 Review

Current Status of Mesenchymal Stem/Stromal Cells for Treatment of Neurological Diseases

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

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A randomized placebo-controlled phase 3 study of mesenchymal stem cells induced to secrete high levels of neurotrophic factors in amyotrophic lateral sclerosis

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Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis

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Dose optimization of intrathecal administration of human umbilical cord mesenchymal stem cells for the treatment of subacute incomplete spinal cord injury

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Efficacy of Intravenous Mesenchymal Stem Cells for Motor Recovery After Ischemic Stroke: A Neuroimaging Study

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Summary: This study investigated the changes in neuroimaging measures using stem cell-based therapy in patients with ischemic stroke. The results showed that stem cell-based therapy can protect the corticospinal tract against degeneration and enhance positive changes in network reorganization to facilitate motor recovery after stroke.

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Neuroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells From Different Donors on Spinal Cord Injury in Mice

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Summary: Spinal cord injury (SCI) can lead to severe dysfunction of the lower limbs, and the inflammatory response plays a crucial role in its prognosis. Transplanting human umbilical cord mesenchymal stem cells (hUCMSCs) can promote SCI repair by reducing inflammation. This study investigated the effects of hUCMSC transplantation on SCI mice and the underlying mechanisms, finding that the therapeutic effects of different hUCMSC lines were correlated with their ability to inhibit BV2 cell proliferation. The MSC_A line showed better improvement in motor function and reduced expression of glial fibrillary acidic protein (Gfap) and ionized calcium binding adaptor molecule 1 (Iba1), while increasing the expression of neuronal nuclei (NeuN).

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The Activation of Mesenchymal Stem Cells by Glioblastoma Microvesicles Alters Their Exosomal Secretion of miR-100-5p, miR-9-5p and let-7d-5p

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Extracellular vesicles derived from inflammatory-educated stem cells reverse brain inflammation-implication of miRNAs

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Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential

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Summary: Stroke, a global disease with high disability rate, has limited options for functional rehabilitation and impacts patients' lives adversely. Mesenchymal stem cells (MSCs) have emerged as a new focus for treatment due to their potential for neuroregeneration, showing therapeutic efficacy in cell migration, angiogenesis, immunomodulation, neuroprotection, and neural circuit reconstruction. Clinical trials on MSCs for treating ischemic stroke have demonstrated safety and feasibility, with challenges in timing and optimal dose of MSC administration. Despite ongoing research, MSC therapy holds potential as a new therapeutic approach for neurological recovery from ischemic stroke in the future.

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Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study

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Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles

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Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-17-3p ameliorates inflammatory reaction and antioxidant injury of mice with diabetic retinopathy via targeting STAT1

Wei Li et al.

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Extracellular vesicles secreted from mesenchymal stem cells exert anti-apoptotic and anti-inflammatory effects via transmitting microRNA-18b in rats with diabetic retinopathy

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Functional Recovery Caused by Human Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles Administered 24 h after Stroke in Rats

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Therapeutic Potential of Exosomal circRNA Derived from Synovial Mesenchymal Cells via Targeting circEDIL3/miR-485-3p/PIAS3/STAT3/ VEGF Functional Module in Rheumatoid Arthritis

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Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2

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Summary: The study demonstrates that extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells have the potential to promote functional recovery after spinal cord injury by facilitating microglia/macrophages polarization from M1-like to M2-like state. This effect is mediated by the increased presence of ubiquitin-specific protease 29 (USP29) in the vesicles, which interacts with and stabilizes nuclear factor-like 2 (NRF2) to regulate microglia/macrophages polarization. Additionally, the study highlights the role of melatonin in reducing global N6-methyladenosine modification and levels of the m(6)A writer METTL3, enhancing the stability of USP29 mRNA in MSCs.

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Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem Cells

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Ophthalmology

Protective effect of LIF-huMSCs on the retina of diabetic model rats

Shan-Na Chen et al.

Summary: The research showed that human umbilical cord mesenchymal stem cells modified by the LIF gene can protect the retina of diabetic rats by regulating the expression levels of specific genes.

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Protective effects of umbilical cord mesenchymal stem cell exosomes in a diabetic rat model through live retinal imaging

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Summary: The study aimed to evaluate the protective effect of human umbilical cord mesenchymal stem cell exosomes (hucMSC-Exs) in a diabetic rat model through various retinal bioassays. Exosomes isolated from hucMSCs were shown to prevent early retinal vascular damage and alleviate retinal structure disruption caused by diabetes, as confirmed by TEM, NTA, WB, FFA, OCT, and HE staining. The findings suggest that hucMSC-Exs have potential as a protective therapy for diabetic retinopathy.

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Cellhesion VP enhances the immunomodulating potential of human mesenchymal stem cell-derived extracellular vesicles

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Summary: The study demonstrated that 3D culture using Cellhesion VP enhanced the expression of stemness genes, migration ability, and extracellular vesicle (EV) production in hMSCs, leading to increased cell proliferation. The EVs derived from Cellhesion VP-primed hMSCs showed potential as a new therapeutic approach for immune and metabolic diseases, exhibiting distinct therapeutic profiles compared to EVs from 2D culture.

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Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5

Qing Chang et al.

Summary: B-Exo promotes recovery of locomotor function and M2-phenotype polarization, inhibits neuronal apoptosis and degeneration, as well as the inflammatory response in rats with SCI. IRF5 expression is reduced after B-Exo treatment, and it promotes macrophage polarization towards M1 phenotype and secretion of inflammatory factors. There is a binding relationship between miR-125a and IRF5, with the knockdown of miR-125a in B-Exo leading to increased IRF5 expression and attenuation of the neuroprotective effect against SCI.

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Human Umbilical Cord-Mesenchymal Stem Cells Survive and Migrate within the Vitreous Cavity and Ameliorate Retinal Damage in a Novel Rat Model of Chronic Glaucoma

Yao Wang et al.

Summary: The study demonstrated that transplanted hUC-MSCs could survive and migrate in the vitreous cavity towards the damaged retina, providing significant neuroprotective effects on chronic glaucomatous retinal damage.

STEM CELLS INTERNATIONAL (2021)

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Article Neurosciences

Safety and Effectiveness of Cell Therapy in Neurodegenerative Diseases: Take-Home Messages From a Pilot Feasibility Phase I Study of Progressive Supranuclear Palsy

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Summary: This study assessed the safety of MSC treatment in patients with PSP and identified critical issues in cell therapies for neurodegenerative diseases. The results showed that MSC treatment did not have a significant impact on 1-year survival rate and occurrence of adverse events in most treated patients.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Toxicology

Bone marrow mesenchymal stem cells-derived exosomes reduce apoptosis and inflammatory response during spinal cord injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway

Liying Fan et al.

Summary: Therapy with exosomes derived from BMSCs can attenuate cell apoptosis and inflammation response in spinal cord injury, while promoting motor function recovery. Exosomes inhibit the TLR4/MyD88/NF-kappa B signaling pathway, suggesting a potential new therapeutic strategy for SCI.

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Bone marrow mesenchymal stem cell therapy regulates gut microbiota to improve post-stroke neurological function recovery in rats

Lin-Na Zhao et al.

Summary: BMSC transplantation is a potential therapeutic option for ischemic stroke, promoting neurological functions through regulation of gut microbiota dysbiosis. The study suggests that BMSC treatment improves neurological function recovery after stroke by reducing necrosis in nerve cells and increasing abundance of beneficial bacteria.

WORLD JOURNAL OF STEM CELLS (2021)

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Article Cell Biology

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Accelerate Functional Recovery After Spinal Cord Injury by Promoting the Phagocytosis of Macrophages to Clean Myelin Debris

Xiaolong Sheng et al.

Summary: The study demonstrated that BMSC-Exos treatment enhances the phagocytic ability of macrophages to clear myelin debris, promoting nerve injury repair and facilitating axon regeneration and functional recovery. Additionally, the promotion of MARCO expression in macrophages by BMSC-Exos contributes to improved myelin debris clearance and tissue repair following SCI.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

Analysis of MicroRNA Profile Alterations in Extracellular Vesicles From Mesenchymal Stromal Cells Overexpressing Stem Cell Factor

Ekaterina Zubkova et al.

Summary: Research has shown that rat adipose-derived MSC-overexpressing stem cell factor (SCF) can induce endogenous regenerative processes and improve cardiac function. Genetic modification of MSC has a great impact on their miRNA composition. This study provides new insights into the regulatory networks underlying extracellular vesicle effects.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

Neuroprotection and Axonal Regeneration Induced by Bone Marrow Mesenchymal Stromal Cells Depend on the Type of Transplant

Maria Norte-Munoz et al.

Summary: The study examines the impact of different types of transplants on neuroprotection and axonal regeneration, finding that syngrafts significantly influence the survival and regeneration of neurons and axons, while xenografts may lead to retinal issues and allografts have limited effects.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Critical Care Medicine

MiR-17-92 Cluster-Enriched Exosomes Derived from Human Bone Marrow Mesenchymal Stromal Cells Improve Tissue and Functional Recovery in Rats after Traumatic Brain Injury

Yanlu Zhang et al.

Summary: Exosomes enriched with miR-17-92 cluster have a significantly better effect on improving functional recovery after TBI compared with Exo-empty, likely by reducing neuroinflammation and enhancing endogenous angiogenesis and neurogenesis. Engineering specific miRNA in exosomes may provide a novel therapeutic strategy for management of unilateral moderate cortical contusion TBI.

JOURNAL OF NEUROTRAUMA (2021)

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Article Medicine, Research & Experimental

MSC-derived exosomal lncRNA SNHG7 suppresses endothelial-mesenchymal transition and tube formation in diabetic retinopathy via miR-34a-5p/XBP1 axis

Xin Cao et al.

Summary: The study demonstrates that lncRNA SNHG7 suppresses EndMT and tube formation in HRMECs through the miR-34a-5p/XBP1 axis, providing new insights into the pathogenesis of diabetic retinopathy.

LIFE SCIENCES (2021)

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Article Health Care Sciences & Services

Probable Factors Associated with Response to Mesenchymal Stem Cell Therapy in Stroke Patients: A Post Hoc Analysis of the STARTING-2 Trial

Won Hyuk Chang et al.

Summary: This study identified factors such as time from stroke onset, age, and weight that influenced the improvement in lower limb motor function of ischemic stroke patients receiving MSC therapy. It suggests that recruiting younger stroke patients soon after the onset of stroke may lead to better outcomes in future clinical trials of MSC therapy for stroke.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Health Care Sciences & Services

A New Tool for Safety Evaluation and a Combination of Measures for Efficacy Assessment of Cotransplanting Human Allogenic Neuronal Stem Cells and Mesenchymal Stem Cells for the Treatment of Parkinson Disease: Protocol for an Interventional Study

Fatima Jamali et al.

Summary: This study aims to investigate the safety and therapeutic benefits of human Wharton jelly-derived mesenchymal stem cells and their derivatives, neuronal stem cells, in Parkinson's disease. With 10 patients enrolled in the study and ongoing data collection and analysis, the combination of NSCs and MSCs may harness the immunomodulation and neural repair characteristics of these cell types in PD. Consideration of this expanded tool set is important for the design of future clinical studies.

JMIR RESEARCH PROTOCOLS (2021)

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Article Cell Biology

Uptake and Distribution of Administered Bone Marrow Mesenchymal Stem Cell Extracellular Vesicles in Retina

Biji Mathew et al.

Summary: Mesenchymal Stem Cell Exosomes/Extracellular Vesicles (MSC EVs) are a promising alternative for treating retinal diseases, promoting immunomodulation, repair, and regeneration. Studies in rats and in vitro experiments have shown that intravitreally administered EVs are effective for treating diseases affecting the inner retina.

CELLS (2021)

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Article Cell & Tissue Engineering

Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis

Suguru Takeuchi et al.

Summary: The study on small extracellular vesicles (sEVs) derived from interferon-gamma pre-conditioned MSCs showed promising potential in ameliorating inflammation and fibrosis in a cirrhosis mouse model. By inducing anti-inflammatory macrophages and regulatory T cells, this therapeutic approach resulted in efficient tissue repair and indicated a new strategy for liver disease treatment.

NPJ REGENERATIVE MEDICINE (2021)

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Article Cell & Tissue Engineering

Looking backward to move forward: a meta-analysis of stem cell therapy in amyotrophic lateral sclerosis

Cynthia Morata-Tarifa et al.

Summary: A meta-analysis was conducted to evaluate the outcomes of stem cell therapy trials for ALS, indicating a transient positive effect on clinical progression with mesenchymal stem cell intrathecal injection, but a worsening of respiratory function. Further research is needed to determine optimal cell products and administration routes for improved outcomes.

NPJ REGENERATIVE MEDICINE (2021)

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Article Cell Biology

Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer’s disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β-catenin pathway

Sha Sha et al.

Aging-US (2021)

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Article Cardiac & Cardiovascular Systems

Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice

Jonas Gregorius et al.

Summary: Obtained from the right cell-type, mesenchymal stromal cell (MSC)-derived small extracellular vesicles (sEVs) promote stroke recovery by enhancing microvascular remodeling. In vitro, sEVs from hypoxic MSCs, but not 'normoxic' MSCs, dose-dependently promoted endothelial proliferation, migration, and tube formation, as well as increased post-ischemic endothelial survival.

BASIC RESEARCH IN CARDIOLOGY (2021)

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Article Engineering, Biomedical

Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration

Zhiwei Liao et al.

Summary: The study demonstrates that metformin enhances the release of EVs and changes their protein profile, improving the quality and quantity of MSCs-derived EVs through an autophagy-related pathway. EVs derived from metformin-treated MSCs ameliorate the senescence of intervertebral disc cells, indicating great potential for intervertebral disc regeneration.

BIOMATERIALS (2021)

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Article Neurosciences

被撤回的出版物: Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3 (Retracted article. See vol. 189, pg. 153, 2022)

Zhibing Ai et al.

Summary: The study found that BMSC-EVs carrying miR-221-3p can inhibit ATF3, exerting a protective effect on MCAO mice and OGD-treated neurons, reducing inflammation, pathological changes, and cell apoptosis, which may help explore therapeutic strategies for IS.

BRAIN RESEARCH BULLETIN (2021)

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Letter Clinical Neurology

Re: Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series

Kazuo Shigematsu et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2021)

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Article Biochemistry & Molecular Biology

Increased Angiogenesis by Exosomes Secreted by Adipose-Derived Stem Cells upon Lipopolysaccharide Stimulation

Shao-Chun Wu et al.

Summary: In this study, it was found that exosomes secreted by lipopolysaccharide-stimulated human ADSCs enhance angiogenesis by activating multiple signaling pathways and increasing the migration and tube formation of HUVECs. RNA interference with CREB, AP-1, or NF-κB1 significantly reduced the pro-angiogenic effects of ADSC-LPS-exo on HUVECs. Additionally, the upregulation of interleukin-8 expression in HUVECs treated with ADSC-LPS-exo suggests its potential role in mediating enhanced angiogenesis. Proteomic analysis also identified several potential candidates involved in ADSC-LPS-exo-mediated angiogenesis enhancement.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

ADMSC Exo-MicroRNA-22 improve neurological function and neuroinflammation in mice with Alzheimer's disease

Liping Zhai et al.

Summary: The study showed that miRNA-22-loaded ADMSC-derived exosomes can reduce inflammatory factor release by inhibiting pyroptosis, thus playing a synergistic role with exosomes in the treatment of AD.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

MSCs-derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6

Chang Cheng et al.

Summary: The study found that MSCs-Exo attenuated cerebral I/R injury in mice by inhibiting microglia apoptosis, possibly through exosomal miR-26a-5p mediated suppression of CDK6. This suggests the potential therapeutic application of MSC-Exo for cerebral I/R injury.

MOLECULAR MEDICINE (2021)

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Article Neurosciences

microRNA-106b-containing extracellular vesicles affect autophagy of neurons by regulating CDKN2B in Parkinson's disease

Xue Bai et al.

Summary: The study demonstrates that EVs containing miR-106b alleviate neuronal apoptosis and enhance neuronal autophagy in Parkinson's disease by downregulating CDKN2B.

NEUROSCIENCE LETTERS (2021)

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Article Cell & Tissue Engineering

Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway

Feifei Huang et al.

Summary: The study showed that bFGF-overexpressing HUCMSCs met clinical safety standards and significantly improved therapeutic outcomes in a mouse SCI model. This included reducing glial scar formation, enhancing nerve regeneration and NSC proliferation, and improving locomotion function recovery. Additionally, bFGF-overexpressing HUCMSCs promoted NSC proliferation and neuronal differentiation in vitro through the PI3K-Akt-GSK-3 beta pathway, supporting the safety and efficacy of gene-modified MSCs for clinical use.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy

Jianyang Liu et al.

Summary: The study demonstrates that hypoxic preconditioning delays OM-MSC senescence and enhances the therapeutic efficacy of OM-MSCs in ICH by upregulating the miR-326/PTBP1/PI3K-mediated autophagy pathway.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

Combining cell therapy with human autologous Schwann cell and bone marrow-derived mesenchymal stem cell in patients with subacute complete spinal cord injury: safety considerations and possible outcomes

Saeed Oraee-Yazdani et al.

Summary: The study showed that autologous SC and bone marrow-derived MSC transplantation during the subacute stage of SCI significantly improved sensory and neurological functions among the patients, particularly in trunk movement, equilibrium in standing/sitting position, the sensation of bladder and rectal filling, and the ability of voluntary voiding.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: critical role of their miRNA cargo

Marwa O. El-Derany et al.

Summary: In this study, BMSCs and BMSCs-Exo were found to successfully restore DOX-induced cognitive and behavioral distortions in rat models of chemobrain. This neuroprotection was achieved through modulation of key signaling pathways, reduction of inflammatory and apoptotic states, and enhancement of antioxidant mediators.

STEM CELL RESEARCH & THERAPY (2021)

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Article Clinical Neurology

Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: a phase I clinical trial

Hee Jin Kim et al.

Summary: Repeated intracerebroventricular injections of hUCB-MSCs were found to be feasible, relatively safe, and well-tolerated in patients with mild-to-moderate Alzheimer's disease dementia. Some mild adverse events were observed but resolved shortly after injection, with no dose-limiting toxicities. The study is ongoing, aiming to gain a deeper understanding of the clinical efficacy of MSC AD therapy through extended follow-up.

ALZHEIMERS RESEARCH & THERAPY (2021)

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Article Medicine, General & Internal

Allogeneic adipose tissue-derived mesenchymal stem cells in ischaemic stroke (AMASCIS-02): a phase IIb, multicentre, double-blind, placebo-controlled clinical trial protocol

Elena de Celis-Ruiz et al.

Summary: Stem cell therapy shows promising potential in reducing sequelae in patients with acute ischaemic stroke, offering a new approach to enhance brain plasticity and improve outcomes.

BMJ OPEN (2021)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cell Sheet Promotes Functional Recovery and Palliates Neuropathic Pain in a Subacute Spinal Cord Injury Model

Kazuyoshi Yamazaki et al.

Summary: The study confirmed that self-produced bone marrow stem cell sheets showed better results in a rat subacute SCI model, promoting significant motor and sensory recovery and displaying smaller injury lesion volume and less inflammation in histological evaluation. These findings suggest that BMSC cell sheets may be a more effective treatment option for SCI.

STEM CELLS INTERNATIONAL (2021)

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Review Neurosciences

From Junk to Function: LncRNAs in CNS Health and Disease

Rafaela Policarpo et al.

Summary: Recent advances in RNA sequencing technologies have revealed the significance of long non-coding RNAs (lncRNAs) in modulating protein-coding gene expression, especially in the central nervous system. Therefore, lncRNAs are gaining attention as potential novel therapeutic targets for brain disorders.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

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Article Clinical Neurology

Long-Term Clinical and Immunological Effects of Repeated Mesenchymal Stem Cell Injections in Patients With Progressive Forms of Multiple Sclerosis

Panayiota Petrou et al.

Summary: Repeated MSC treatments in patients with progressive MS were shown to be safe in the short/intermediate term and induced clinical benefits that lasted for up to 4 years, paralleled by short-term immunomodulatory effects.

FRONTIERS IN NEUROLOGY (2021)

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Article Medicine, Research & Experimental

Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS

Yuri Ciervo et al.

Summary: Mouse adipose-derived stem cells (ADSCs) injected into ALS mice improved motor function, delayed disease onset, and protected motor neurons by reducing glial activation. In vitro studies also showed that ADSCs rescued motor neurons from ALS astrocytes' neurotoxicity and reduced the inflammatory response in ALS astrocytes. Additionally, ADSCs were found to protect motor neurons from neurotoxicity mediated by human induced astrocytes derived from ALS patients, suggesting a potential therapeutic translation of ADSCs for human ALS.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

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Article Cell Biology

Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF-β upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury

Masahito Nakazaki et al.

Summary: Intravenous infusion of bone marrow-derived mesenchymal stem/stromal cells (MSCs) leads to the release of small extracellular vesicles (sEVs) that can target the injury site in spinal cord injury (SCI) rats and interact with M2 macrophages. Fractionated dosing of MSC-sEVs over 3 days is required to achieve therapeutic effects, mimicking the results of single MSC infusion. These findings suggest that the release of sEVs by MSCs over time induces a cascade of cellular responses leading to improved functional recovery.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Cell Biology

Priming With Toll-Like Receptor 3 Agonist Poly(I:C) Enhances Content of Innate Immune Defense Proteins but Not MicroRNAs in Human Mesenchymal Stem Cell-Derived Extracellular Vesicles

Lisa M. Pierce et al.

Summary: Priming MSCs with poly(I:C) can enhance the antimicrobial function of EVs by upregulating certain proteins related to host defense and innate immunity, while not significantly affecting the miRNA content. Functional annotation clustering analysis highlights enrichment in biological processes including immune response and pathogen infection pathways. Further investigation is needed to determine the importance of specific functional EV proteins and their signaling pathways during interaction with immune cells.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Correction Cell Biology

Corrigendum: Transplanted Erythropoietin-Expressing Mesenchymal Stem Cells Promote Pro-survival Gene Expression and Protect Photoreceptors From Sodium Iodate-Induced Cytotoxicity in a Retinal Degeneration Model

Avin Ee-Hwan Koh et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Implantation of nanofibrous silk scaffolds seeded with bone marrow stromal cells promotes spinal cord regeneration (6686 words)

Xin-Hong Wang et al.

Summary: The study demonstrated the potential therapeutic effects of a three-dimensional porous silk fibroin scaffold seeded with bone marrow stromal cells in a spinal cord injury model, leading to improved regeneration at the injury site and enhanced hindlimb movement recovery as shown by increased BBB scores.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

A phase II clinical trial with repeated intrathecal injections of autologous mesenchymal stem cells in patients with amyotrophic lateral sclerosis

Panayiota Petrou et al.

Summary: The results of the study indicated that repeated intrathecal injections of autologous MSC in ALS patients were safe and showed medium-term clinical benefits, which were related to the intervals between cell administrations. Larger studies are needed to confirm these observations.

FRONTIERS IN BIOSCIENCE-LANDMARK (2021)

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Article Biotechnology & Applied Microbiology

Bone mesenchymal stem cell-derived extracellular vesicles deliver microRNA-23b to alleviate spinal cord injury by targeting toll-like receptor TLR4 and inhibiting NF-κB pathway activation

Hongfei Nie et al.

Summary: miR-23b delivered by BMSC-EVs targets TLR4 and inhibits NF-kappa B pathway activation, relieving inflammatory response and improving SCI in rats.

BIOENGINEERED (2021)

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Article Endocrinology & Metabolism

microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis

Zixin Hou et al.

Summary: This study demonstrates that EVs derived from ASCs can inhibit neuronal damage by delivering miR-26a, which targets KLF9 to regulate the TRAF2/KLF2 axis.

ADIPOCYTE (2021)

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Review Psychology, Developmental

Genetic Advances in Autism

Anita Thapar et al.

Summary: Autism is highly heritable, with rare variants of large effect size and common gene variants of small effect all contributing to its risk. Recent research challenges traditional diagnostic boundaries and highlights the vast heterogeneity of autism.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2021)

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Article Biochemistry & Molecular Biology

Effects of a combinatorial treatment with gene and cell therapy on retinal ganglion cell survival and axonal outgrowth after optic nerve injury

Gabriel Nascimento-dos-Santos et al.

GENE THERAPY (2020)

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Article Cell Biology

Intranasal delivery of SDF-1α-preconditioned bone marrow mesenchymal cells improves remyelination in the cuprizone-induced mouse model of multiple sclerosis

Fatemeh Beigi Boroujeni et al.

CELL BIOLOGY INTERNATIONAL (2020)

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Article Medicine, General & Internal

CELLTOP Clinical Trial: First Report From a Phase 1 Trial of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells in the Treatment of Paralysis Due to Traumatic Spinal Cord Injury

Mohamad Bydon et al.

MAYO CLINIC PROCEEDINGS (2020)

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Article Engineering, Biomedical

Post-production modifications of murine mesenchymal stem cell (mMSC) derived extracellular vesicles (EVs) and impact on their cellular interaction

Sarah Le Saux et al.

BIOMATERIALS (2020)

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Article Cell Biology

Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity

Litao Yan et al.

CELL BIOLOGY AND TOXICOLOGY (2020)

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Article Neurosciences

The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function

Jiankun Zang et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain

Maheedhar Kodali et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Immunology

Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway

Kun Hou et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Multidisciplinary Sciences

Repeated intramuscular transplantations of hUCB-MSCs improves motor function and survival in the SOD1 G93A mice through activation of AMPK

Myung Geun Kook et al.

SCIENTIFIC REPORTS (2020)

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Article Cell & Tissue Engineering

Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1G93A mice

Anna Martinez-Muriana et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Biochemistry & Molecular Biology

Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-α-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a

Guijun Cao et al.

BIOSCIENCE REPORTS (2020)

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Article Cell & Tissue Engineering

Trends in mesenchymal stem cell clinical trials 2004-2018: Is efficacy optimal in a narrow dose range?

Maciej Kabat et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

Proteomic Analysis of Exosomes from Adipose-Derived Mesenchymal Stem Cells: A Novel Therapeutic Strategy for Tissue Injury

Xin Xing et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Biotechnology & Applied Microbiology

Exosomes derived from adipose mesenchymal stem cells: a potential non-invasive intranasal treatment for autism

Y. Geffen et al.

CYTOTHERAPY (2020)

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Review Pharmacology & Pharmacy

Microglia and mast cells generate proinflammatory cytokines in the brain and worsen inflammatory state: Suppressor effect of IL-37

Pio Conti et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Cell & Tissue Engineering

Intravenous Human Umbilical Cord-Derived Mesenchymal Stromal Cell Administration in Models of Moderate and Severe Intracerebral Hemorrhage

Tanira Giara Mello et al.

STEM CELLS AND DEVELOPMENT (2020)

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Article Cell Biology

Extracellular vesicle-mediated transfer of miR-21-5p from mesenchymal stromal cells to neurons alleviates early brain injury to improve cognitive function via the PTEN/Akt pathway after subarachnoid hemorrhage

Xiao Gao et al.

CELL DEATH & DISEASE (2020)

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Article Cell & Tissue Engineering

Extracellular vesicles derived from human ES-MSCs protect retinal ganglion cells and preserve retinal function in a rodent model of optic nerve injury

Seyedeh-Zahra Seyedrazizadeh et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Clinical Neurology

Autologous Mesenchymal Stem Cells Improve Motor Recovery in Subacute Ischemic Stroke: a Randomized Clinical Trial

Assia Jaillard et al.

TRANSLATIONAL STROKE RESEARCH (2020)

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Article Biotechnology & Applied Microbiology

Repairing and Analgesic Effects of Umbilical Cord Mesenchymal Stem Cell Transplantation in Mice with Spinal Cord Injury

Ling-ling Wu et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Cardiac & Cardiovascular Systems

Activated Mesenchymal Stem Cells Induce Recovery Following Stroke Via Regulation of Inflammation and Oligodendrogenesis

Matthew K. Tobin et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Article Biotechnology & Applied Microbiology

Comprehensive Molecular Profiles of Functionally Effective MSC-Derived Extracellular Vesicles in Immunomodulation

Hyemee Kim et al.

MOLECULAR THERAPY (2020)

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Article Oncology

Effects of bone marrow mesenchymal stem cells transplantation on the recovery of neurological functions and the expression of Nogo-A, NgR, Rhoa, and ROCK in rats with experimentally-induced convalescent cerebral ischemia

Jianbo Zhang et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Article Ophthalmology

Systemic Mesenchymal Stem Cell Treatment Mitigates Structural and Functional Retinal Ganglion Cell Degeneration in a Mouse Model of Multiple Sclerosis

Oliver W. Gramlich et al.

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2020)

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Article Engineering, Biomedical

Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p

Danqing Xin et al.

ACTA BIOMATERIALIA (2020)

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Review Cell Biology

Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages

Kasra Asgarpour et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Article Oncology

Subarachnoid transplantation of human umbilical cord mesenchymal stem cell in rodent model with subacute incomplete spinal cord injury: Preclinical safety and efficacy study

Yang Yang et al.

EXPERIMENTAL CELL RESEARCH (2020)

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Article Chemistry, Medicinal

Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-kappa B Signaling Pathway Modulation

Min Han et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

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Article Cell & Tissue Engineering

Management of retinitis pigmentosa by Wharton's jelly-derived mesenchymal stem cells: prospective analysis of 1-year results

Emin Ozmert et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Cell & Tissue Engineering

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease

Morris Losurdo et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

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Article Cell & Tissue Engineering

Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder

Jessica M. Sun et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Enhancing the Therapeutic Potential of CCL2-Overexpressing Mesenchymal Stem Cells in Acute Stroke

Sanghun Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Neurosciences

Mesenchymal Stem Cell-Conditioned Medium Improves Mitochondrial Dysfunction and Suppresses Apoptosis in Okadaic Acid-Treated SH-SY5Y Cells by Extracellular Vesicle Mitochondrial Transfer

Zhihua Zhang et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

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Article Medicine, General & Internal

The effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis A comparative study

Alia A. Alghwiri et al.

MEDICINE (2020)

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Review Cell & Tissue Engineering

Modeling ALS using iPSCs: Is it possible to reproduce the phenotypic variations observed in patientsin vitro?

Juliana Ferreira Vasques et al.

REGENERATIVE MEDICINE (2020)

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Article Neurosciences

Kinematic Changes in a Mouse Model of Penetrating Hippocampal Injury and Their Recovery After Intranasal Administration of Endometrial Mesenchymal Stem Cell-Derived Extracellular Vesicles

Lilia Carolina Leon-Moreno et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Article Multidisciplinary Sciences

A highly efficient non-viral process for programming mesenchymal stem cells for gene directed enzyme prodrug cancer therapy

Yoon Khei Ho et al.

SCIENTIFIC REPORTS (2020)

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Article Genetics & Heredity

Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B

N. Perets et al.

MOLECULAR AUTISM (2020)

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Review Cell Biology

Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine

Patricia Kauanna Fonseca Damasceno et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Cell Biology

Exosomes Derived From CircAkap7-Modified Adipose-Derived Mesenchymal Stem Cells Protect Against Cerebral Ischemic Injury

Limin Xu et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Hydrogen sulfide-modified extracellular vesicles from mesenchymal stem cells for treatment of hypoxic-ischemic brain injury

Xili Chu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article

BILATERAL EPIRETINAL MEMBRANE FORMATION AFTER INTRAVITREAL INJECTIONS OF AUTOLOGOUS MESENCHYMAL STEM CELLS

Megan A. Kasetty et al.

Retinal Cases and Brief Reports (2020)

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Article Nanoscience & Nanotechnology

Mesenchymal Stem Cell-Derived Exosomes for Treatment of Autism Spectrum Disorder

Yujie Liang et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Cell & Tissue Engineering

Treatment of traumatic optic neuropathy using human placenta-derived mesenchymal stem cells in Asian patients

Youngje Sung et al.

REGENERATIVE MEDICINE (2020)

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Article Multidisciplinary Sciences

Human mesenchymal stromal/stem cells recruit resident pericytes and induce blood vessels maturation to repair experimental spinal cord injury in rats

Karla Menezes et al.

SCIENTIFIC REPORTS (2020)

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Review Clinical Neurology

Rodent Models of Optic Neuritis

Yael Redler et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Medicine, Research & Experimental

Exosomes from MSCs overexpressing microRNA-223-3p attenuate cerebral ischemia through inhibiting microglial M1 polarization mediated inflammation

Yangmin Zhao et al.

LIFE SCIENCES (2020)

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Article Medicine, Research & Experimental

Human Wharton's jelly mesenchymal stem cells protect neural cells from oxidative stress through paracrine mechanisms

Teresa Puig-Pijuan et al.

FUTURE SCIENCE OA (2020)

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Review Cell & Tissue Engineering

Manipulated Mesenchymal Stem Cells Applications in Neurodegenerative Diseases

Seyyed Omid Sadatpoor et al.

INTERNATIONAL JOURNAL OF STEM CELLS (2020)

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Article Medicine, General & Internal

Downregulation of Long Noncoding RNA MIAT in the Retina of Diabetic Rats with Tail-vein Injection of Human Umbilical-cord Mesenchymal Stem Cells

Chuan Yu et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

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Article Public, Environmental & Occupational Health

Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016

Matthew J. Maenner et al.

MMWR SURVEILLANCE SUMMARIES (2020)

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Article Medicine, Research & Experimental

Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway

Bing Yan et al.

THERANOSTICS (2020)

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Article Ophthalmology

Impact and Trends in Global Ophthalmology

Lloyd B. Williams et al.

CURRENT OPHTHALMOLOGY REPORTS (2020)

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Article Neurosciences

Therapeutic Potential of a Combination of Electroacupuncture and TrkB-Expressing Mesenchymal Stem Cells for Ischemic Stroke

Sung Min Ahn et al.

MOLECULAR NEUROBIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Membrane lipids define small extracellular vesicle subtypes secreted by mesenchymal stromal cells

Ruenn Chai Lai et al.

JOURNAL OF LIPID RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered Mesenchymal Stromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice

Renata Lejkowska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Clinical Neurology

Transforming Growth Factor-β Promotes Homing and Therapeutic Efficacy of Human Mesenchymal Stem Cells to Glioblastoma

Man Li et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2019)

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Article Cell & Tissue Engineering

Analysis of the therapeutic potential of different administration routes and frequencies of human mesenchymal stromal cells in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Franziska Bursch et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

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Article Neurosciences

Effects of Different Doses of Mesenchymal Stem Cells on Functional Recovery After Compressive Spinal-Cord Injury in Mice

Bruna dos Santos Ramalho et al.

NEUROSCIENCE (2019)

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Article Cell & Tissue Engineering

A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1G93A Rats

Monika Rehorova et al.

STEM CELLS TRANSLATIONAL MEDICINE (2019)

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Article Cell & Tissue Engineering

Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture Systems

Vitale Miceli et al.

STEM CELLS INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

Enhanced Homing of Mesenchymal Stem Cells Overexpressing Fibroblast Growth Factor 21 to Injury Site in a Mouse Model of Traumatic Brain Injury

Rami Ahmad Shahror et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Intrathecal transplantation of Wharton's jelly mesenchymal stem cells suppresses the NLRP1 inflammasome in the rat model of spinal cord injury

Yousef Mohamadi et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2019)

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Article Peripheral Vascular Disease

Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke

Kaiming Liu et al.

MICROVASCULAR RESEARCH (2019)

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Article Medicine, Research & Experimental

MEsenchymal StEm cells for Multiple Sclerosis (MESEMS): a randomized, double blind, cross-over phase I/II clinical trial with autologous mesenchymal stem cells for the therapy of multiple sclerosis

Antonio Uccelli et al.

TRIALS (2019)

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Article Cell & Tissue Engineering

Long-term neuronal survival, regeneration, and transient target reconnection after optic nerve crush and mesenchymal stem cell transplantation

Louise A. Mesentier-Louro et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Cell & Tissue Engineering

IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury

Kyan James Allandadi et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Medicine, Research & Experimental

Mesenchymal stem cell derived EVs mediate neuroprotection after spinal cord injury in rats via the microRNA-21-5p/FasL gene axis

Xin Zhou et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Neurosciences

Bone-marrow mononuclear cell therapy in a mouse model of amyotrophic lateral sclerosis: Functional outcomes from different administration routes

Fernanda Gubert et al.

BRAIN RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Adipose-derived mesenchymal stem cells stereotactic transplantation alleviate brain edema from intracerebral hemorrhage

Ye Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Oncology

Therapeutic effect of transplantation of human bone marrow-derived mesenchymal stem cells on neuron regeneration in a rat model of middle cerebral artery occlusion

Ping Xie et al.

MOLECULAR MEDICINE REPORTS (2019)

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Article Multidisciplinary Sciences

Safety and Efficacy of Intraventricular Delivery of Bone Marrow-Derived Mesenchymal Stem Cells in Hemorrhagic Stroke Model

Peng Huang et al.

SCIENTIFIC REPORTS (2019)

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Article Cell & Tissue Engineering

Allogeneic Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Autism Spectrum Disorder in Children: Safety Profile and Effect on Cytokine Levels

Neil H. Riordan et al.

STEM CELLS TRANSLATIONAL MEDICINE (2019)

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Review Medicine, General & Internal

Adipose Tissue Stem Cells for Therapy: An Update on the Progress of Isolation, Culture, Storage, and Clinical Application

Dinh-Toi Chu et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Review Cell Biology

Mesenchymal Stem Cell Migration and Tissue Repair

Xiaorong Fu et al.

CELLS (2019)

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Article Engineering, Biomedical

Characterizing the impact of 2D and 3D culture conditions on the therapeutic effects of human mesenchymal stem cell secretome on corneal wound healing in vitro and ex vivo

Kaylene Carter et al.

ACTA BIOMATERIALIA (2019)

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Review Biophysics

Mesenchymal stem cell-derived exosomes for clinical use

Mayela Mendt et al.

BONE MARROW TRANSPLANTATION (2019)

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Article Cell & Tissue Engineering

Aggregation of human mesenchymal stem cells enhances survival and efficacy in stroke treatment

Xuegang Yuan et al.

CYTOTHERAPY (2019)

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Review Biochemistry & Molecular Biology

Adult Stem Cell Therapeutics in Diabetic Retinopathy

Sriprachodaya Gaddam et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells

Minna Holopainen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2019)

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Article Biochemistry & Molecular Biology

Biodistribution of Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Radiation Injury Bone Marrow Murine Model

Sicheng Wen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Clinical Neurology

Two-year safety and clinical outcomes in chronic ischemic stroke patients after implantation of modified bone marrow-derived mesenchymal stem cells (SB623): a phase 1/2a study

Gary K. Steinberg et al.

JOURNAL OF NEUROSURGERY (2019)

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Article Clinical Neurology

Phase I/II Study of Safety and Preliminary Efficacy of Intravenous Allogeneic Mesenchymal Stem Cells in Chronic Stroke

Michael L. Levy et al.

STROKE (2019)

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Article Cell & Tissue Engineering

Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

Victor Bodart-Santos et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Cell & Tissue Engineering

Mesenchymal stromal cell therapy: progress in manufacturing and assessments of potency

Kevin P. Robb et al.

CYTOTHERAPY (2019)

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Review Neurosciences

Hypoxia conditioning enhances neuroprotective effects of aged human bone marrow mesenchymal stem cell-derived conditioned medium against cerebral ischemia in vitro

Ying Zhang et al.

BRAIN RESEARCH (2019)

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Article Biochemistry & Molecular Biology

UMSC-derived exosomes promote retinal ganglion cells survival in a rat model of optic nerve crush

Dongyan Pan et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2019)

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Article Cell & Tissue Engineering

Exosomes Derived from Human Primed Mesenchymal Stem Cells Induce Mitosis and Potentiate Growth Factor Secretion

Oliver Yuan et al.

STEM CELLS AND DEVELOPMENT (2019)

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Article Cell & Tissue Engineering

Extracellular Vesicles from Wharton's Jelly Mesenchymal Stem Cells Suppress CD4 Expressing T Cells Through Transforming Growth Factor Beta and Adenosine Signaling in a Canine Model

Sarah K. Crain et al.

STEM CELLS AND DEVELOPMENT (2019)

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Article Clinical Neurology

Application of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Stroke: Biodistribution and MicroRNA Study

Gyeong Joon Moon et al.

TRANSLATIONAL STROKE RESEARCH (2019)

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Article Biotechnology & Applied Microbiology

Unraveling the Molecular Signature of Extracellular Vesicles From Endometrial-Derived Mesenchymal Stem Cells: Potential Modulatory Effects and Therapeutic Applications

Federica Marinaro et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Article Cell & Tissue Engineering

Efficient One-Step Induction of Human Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs) Produces MSC-Derived Neurospheres (MSC-NS) with Unique Transcriptional Profile and Enhanced Neurogenic and Angiogenic Secretomes

Chunyang Peng et al.

STEM CELLS INTERNATIONAL (2019)

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Review Neurosciences

ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?

Rita Mejzini et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Multidisciplinary Sciences

Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition

Reka Agnes Haraszti et al.

ISCIENCE (2019)

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Article Cell Biology

Safety of intrathecal injection of Wharton's jelly-derived mesenchymal stem cells in amyotrophic lateral sclerosis therapy

Monika Barczewska et al.

NEURAL REGENERATION RESEARCH (2019)

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Review Cell & Tissue Engineering

Mesenchymal stem cells for hemorrhagic stroke: status of preclinical and clinical research

Marion T. Turnbull et al.

NPJ REGENERATIVE MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid- oligomers

Mariana A. de Godoy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Endocrinology & Metabolism

Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke

Susumu Yamaguchi et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2018)

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Article Clinical Neurology

Pilot trial of intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosis

Jeffrey A. Cohen et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

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Article Clinical Neurology

Pilot trial of intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosis

Jeffrey A. Cohen et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

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Article Behavioral Sciences

Behavioral assessments of BTBR T+Itpr3tf/J mice by tests of object attention and elevated open platform: Implications for an animal model of psychiatric comorbidity in autism

Owen Y. Chao et al.

BEHAVIOURAL BRAIN RESEARCH (2018)

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Article Cell & Tissue Engineering

Serum-mediated Activation of Bone Marrow-derived Mesenchymal Stem Cells in lschemic Stroke Patients: A Novel Preconditioning Method

Gyeong Joon Moon et al.

CELL TRANSPLANTATION (2018)

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Article Cell & Tissue Engineering

Significant Improvement of Acute Complete Spinal Cord Injury Patients Diagnosed by a Combined Criteria Implanted with NeuroRegen Scaffolds and Mesenchymal Stem Cells

Zhifeng Xiao et al.

CELL TRANSPLANTATION (2018)

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Article Cell & Tissue Engineering

Intrathecal administration of autologous mesenchymal stromal cells for spinal cord injury: Safety and efficacy of the 100/3 guideline

Jesus Vaquero et al.

CYTOTHERAPY (2018)

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Article Neurosciences

Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders

Staci D. Bilbo et al.

EXPERIMENTAL NEUROLOGY (2018)

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Article Biochemistry & Molecular Biology

The Effect of Human Mesenchymal Stem Cells Derived from Wharton's Jelly in Spinal Cord Injury Treatment Is Dose-Dependent and Can Be Facilitated by Repeated Application

Petr Krupa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Cell Biology

Preconditioning influences mesenchymal stem cell properties in vitro and in vivo

Chenxia Hu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Role of Exosomes Derived from miR-133b Modified MSCs in an Experimental Rat Model of Intracerebral Hemorrhage

Haitao Shen et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2018)

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Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis

Neil H. Riordan et al.

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Injection of bone marrow mesenchymal stem cells by intravenous or intraperitoneal routes is a viable alternative to spinal cord injury treatment in mice

Bruna dos Santos Ramalho et al.

NEURAL REGENERATION RESEARCH (2018)

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Human Placenta-Derived Mesenchymal Stem Cells Reduce Mortality and Hematoma Size in a Rat Intracerebral Hemorrhage Model in an Acute Phase

Bo Young Choi et al.

STEM CELLS INTERNATIONAL (2018)

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Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder

Nermin Eissa et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Adipose-Derived Mesenchymal Stem Cell Application Combined With Fibrin Matrix Promotes Structural and Functional Recovery Following Spinal Cord Injury in Rats

Yana O. Mukhamedshina et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Phase I Trial of Intrathecal Mesenchymal Stem Cell-derived Neural Progenitors in Progressive Multiple Sclerosis

Violaine K. Harris et al.

EBIOMEDICINE (2018)

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Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis

Ki-Wook Oh et al.

ANNALS OF NEUROLOGY (2018)

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Efficacy and Safety of Autologous Bone Marrow Mesenchymal Stem Cell Transplantation in Patients with Diabetic Retinopathy

Xianliang Gu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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The immunomodulatory activity of extracellular vesicles derived from endometrial mesenchymal stem cells on CD4+T cells is partially mediated by TGFbeta

Veronica Alvarez et al.

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Comparing atmospheric and hypoxic cultured mesenchymal stem cell transcriptome: implication for stem cell therapies targeting intervertebral discs

C. Elabd et al.

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Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy

Josemar Marchezan et al.

NEUROIMMUNOMODULATION (2018)

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Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts' Recommendations: Choosing Optimal Monitoring Tools

Magdalena Kuzma-Kozakiewicz et al.

STEM CELLS INTERNATIONAL (2018)

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Human Wharton's jelly mesenchymal stem cells protect axotomized rat retinal ganglion cells via secretion of anti-inflammatory and neurotrophic factors

Jose E. Millan-Rivero et al.

SCIENTIFIC REPORTS (2018)

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Targeted-pig trial on safety and immunogenicity of serum-derived extracellular vesicles enriched fractions obtained from Porcine Respiratory and Reproductive virus infections

Sergio Montaner-Tarbes et al.

SCIENTIFIC REPORTS (2018)

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Combination therapy of human bone marrow-derived mesenchymal stem cells and minocycline improves neuronal function in a rat middle cerebral artery occlusion model

Dong Young Cho et al.

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Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

Nisim Perets et al.

MOLECULAR AUTISM (2018)

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Stem cell therapy in autism: recent insights

Dario Siniscalco et al.

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Targeted homing of CCR2-overexpressing mesenchymal stromal cells to ischemic brain enhances post-stroke recovery partially through PRDX4-mediated blood-brain barrier preservation

Yinong Huang et al.

THERANOSTICS (2018)

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Bone marrow stromal cell sheets may promote axonal regeneration and functional recovery with suppression of glial scar formation after spinal cord transection injury in rats

Akinori Okuda et al.

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Preconditioning of adipose tissue-derived mesenchymal stem cells with deferoxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors: Potential application in the treatment of diabetic neuropathy

Carolina Oses et al.

PLOS ONE (2017)

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Multiple intracerebroventricular injections of human umbilical cord mesenchymal stem cells delay motor neurons loss but not disease progression of SOD1G93A mice

Francesca Sironi et al.

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Integrin α4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection

Li-li Cui et al.

STROKE (2017)

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Hypoxia Enhances Cell Properties of Human Mesenchymal Stem Cells

Se Yun Kwon et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

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Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

Elena Redondo-Castro et al.

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Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms

Ben Mead et al.

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Hypoxia Enhances Cell Properties of Human Mesenchymal Stem Cells

Se Yun Kwon et al.

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Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis

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Vital Signs: Recent Trends in Stroke Death Rates - United States, 2000-2015

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Traumatic spinal cord injury

Christopher S. Ahuja et al.

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The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

Junichi Matsumoto et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

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Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats

Chikako Morioka et al.

INFLAMMATION AND REGENERATION (2017)

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Transplantation of Mesenchymal Stromal Cells in Patients With Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial

Eva Sykova et al.

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Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer

Thomas J. Morrison et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

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Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study

Ticiana Ferreira Larocca et al.

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Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism

Nisim Perets et al.

BEHAVIOURAL BRAIN RESEARCH (2017)

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Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

Xiaohua Zhu et al.

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Developmental microglial priming in postmortem autism spectrum disorder temporal cortex

Andrew S. Lee et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

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Repeated subarachnoid administrations of autologous mesenchymal stromal cells supported in autologous plasma improve quality of life in patients suffering incomplete spinal cord injury

Jesus Vaquero et al.

CYTOTHERAPY (2017)

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Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice

Hadar Segal-Gavish et al.

AUTISM RESEARCH (2016)

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Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial

Junseok W. Hur et al.

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Characterization of human mesenchymal stem cells from multiple donors and the implications for large scale bioprocess development

Thomas R. J. Heathman et al.

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Mechanism and Therapy of Brain Edema after Intracerebral Hemorrhage

Haiping Zheng et al.

CEREBROVASCULAR DISEASES (2016)

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Impact of Autologous Mesenchymal Stem Cell Infusion on Neuromyelitis Optica Spectrum Disorder: A Pilot, 2-Year Observational Study

Ying Fu et al.

CNS NEUROSCIENCE & THERAPEUTICS (2016)

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Autologous mesenchymal stromal cell transplantation for spinal cord injury: A Phase I pilot study

Humayoon Shafique Satti et al.

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Mesenchymal stromal cell-mediated neuroprotection and functional preservation of retinal ganglion cells in a rodent model of glaucoma

Ben Mead et al.

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An approach to personalized cell therapy in chronic complete paraplegia: The Puerta de Hierro phase I/II clinical trial

Jesus Vaquero et al.

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International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials

Jacques Galipeau et al.

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Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease

Gabriel R. Linares et al.

EXPERIMENTAL NEUROLOGY (2016)

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Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Debbie Le Blon et al.

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Finding a new therapeutic approach for no-option Parkinsonisms: mesenchymal stromal cells for progressive supranuclear palsy

Margherita Canesi et al.

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Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment

Jeffrey N. Weiss et al.

NEURAL REGENERATION RESEARCH (2016)

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Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow-derived stem cells in the treatment of Leber's hereditary optic neuropathy

Jeffrey N. Weiss et al.

NEURAL REGENERATION RESEARCH (2016)

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Integrated systems of stroke care and reduction in 30-day mortality A retrospective analysis

Aravind Ganesh et al.

NEUROLOGY (2016)

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INTRAVENOUS INFUSION OF MESENCHYMAL STEM CELLS PROMOTES FUNCTIONAL RECOVERY IN A MODEL OF CHRONIC SPINAL CORD INJURY

Tomonori Morita et al.

NEUROSCIENCE (2016)

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Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke A Phase 1/2a Study

Gary K. Steinberg et al.

STROKE (2016)

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Editorial Material Hematology

Next-generation mesenchymal stem or stromal cells for the in vivo delivery of bioactive factors: progressing toward the clinic

Jan A. Nolta

TRANSFUSION (2016)

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Preconditioning of bone marrow mesenchymal stem cells with hydrogen sulfide improves their therapeutic potential

Qun Zhang et al.

ONCOTARGET (2016)

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Intraspinal bone-marrow cell therapy at pre- and symptomatic phases in a mouse model of amyotrophic lateral sclerosis

Fernanda Gubert et al.

STEM CELL RESEARCH & THERAPY (2016)

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Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis Results of Phase 1/2 and 2a Clinical Trials

Panayiota Petrou et al.

JAMA NEUROLOGY (2016)

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Human Mesenchymal Stromal Cells from Different Sources Diverge in Their Expression of Cell Surface Proteins and Display Distinct Differentiation Patterns

Kourosch C. Elahi et al.

STEM CELLS INTERNATIONAL (2016)

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Retinal Electrophysiological Effects of Intravitreal Bone Marrow Derived Mesenchymal Stem Cells in Streptozotocin Induced Diabetic Rats

Eren Cerman et al.

PLOS ONE (2016)

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Umbilical Cord Tissue Offers the Greatest Number of Harvestable Mesenchymal Stem Cells for Research and Clinical Application: A Literature Review of Different Harvest Sites

C. Thomas Vangsness et al.

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2015)

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Topographical cues regulate the crosstalk between MSCs and macrophages

Gema Valles et al.

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Human adipose-derived stromal cells in a clinically applicable injectable alginate hydrogel: Phenotypic and immunomodulatory evaluation

Bjarke Follin et al.

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Neuroprotective effects of intravitreally transplanted adipose tissue and bone marrow-derived mesenchymal stem cells in an experimental ocular hypertension model

Esra Emre et al.

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Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a case report of improvement in relapsing auto-immune optic neuropathy

Jeffrey N. Weiss et al.

NEURAL REGENERATION RESEARCH (2015)

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Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report

Jeffrey N. Weiss et al.

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High-Throughput Microfluidic Platform for 3D Cultures of Mesenchymal Stem Cells, Towards Engineering Developmental Processes

Paola Occhetta et al.

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Phase I Trial of Repeated Intrathecal Autologous Bone Marrow-Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis

Ki-Wook Oh et al.

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Hypoxia Enhances Proliferation of Human Adipose-Derived Stem Cells via HIF-1α Activation

Natsuko Kakudo et al.

PLOS ONE (2015)

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The Effect of Hypoxia on Mesenchymal Stem Cell Biology

Mostafa Ejtehadifar et al.

ADVANCED PHARMACEUTICAL BULLETIN (2015)

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Extracellular vesicles derived from mesenchymal stem cells induce features of diabetic retinopathy in vitro

Elena Beltramo et al.

ACTA DIABETOLOGICA (2014)

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The role of growth factors in maintenance of sternness in bone marrow-derived mesenchymal stem cells

Young Woo Eom et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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Serum-Free Spheroid Suspension Culture Maintains Mesenchymal Stem Cell Proliferation and Differentiation Potential

Stella Alimperti et al.

BIOTECHNOLOGY PROGRESS (2014)

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Sustained effect of bone marrow mononuclear cell therapy in axonal regeneration in a model of optic nerve crush

Camila Zaverucha-do-Valle et al.

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Intracranial haemorrhage: therapeutic interventions and anaesthetic management

P. Fogarty Mack

BRITISH JOURNAL OF ANAESTHESIA (2014)

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Human mesenchymal stem cell spheroids in fibrin hydrogels exhibit improved cell survival and potential for bone healing

Kaitlin C. Murphy et al.

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A novel three-dimensional adipose-derived stem cell cluster for vascular regeneration in ischemic tissue

In Su Park et al.

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Autologous mesenchymal stem cell therapy for progressive supranuclear palsy: translation into a phase I controlled, randomized clinical study

Rosaria Giordano et al.

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Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

Ying Wang et al.

NATURE IMMUNOLOGY (2014)

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Interplay of matrix stiffness and protein tethering in stem cell differentiation

Jessica H. Wen et al.

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Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury

Fatemeh Anbari et al.

NEURAL REGENERATION RESEARCH (2014)

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Expansion of Human Mesenchymal Stromal Cells from Fresh Bone Marrow in a 3D Scaffold-Based System under Direct Perfusion

Adam Papadimitropoulos et al.

PLOS ONE (2014)

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Distribution of Mesenchymal Stem Cells and Effects on Neuronal Survival and Axon Regeneration after Optic Nerve Crush and Cell Therapy

Louise Alessandra Mesentier-Louro et al.

PLOS ONE (2014)

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Randomized Placebo-Controlled Phase II Trial of Autologous Mesenchymal Stem Cells in Multiple Sclerosis

Sara Llufriu et al.

PLOS ONE (2014)

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Biological Markers of Mesenchymal Stromal Cells as Predictors of Response to Autologous Stem Cell Transplantation in Patients With Amyotrophic Lateral Sclerosis: An Investigator-Initiated Trial and In Vivo Study

Hyun Young Kim et al.

STEM CELLS (2014)

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Intrathecal Delivery of Mesenchymal Stromal Cells Protects the Structure of Altered Perineuronal Nets in SOD1 Rats and Amends the Course of ALS

Serhiy Forostyak et al.

STEM CELLS (2014)

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Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility

Tokiko Nagamura-Inoue

World Journal of Stem Cells (2014)

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Different culture media affect growth characteristics, surface marker distribution and chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells

Sebastien Hagmann et al.

BMC MUSCULOSKELETAL DISORDERS (2013)

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Potency assay development for cellular therapy products: an ISCT review of the requirements and experiences in the industry

Christopher A. Bravery et al.

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Human marrow stromal cells reduce microglial activation to protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis

Chang Zhou et al.

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Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism

Yong-Tao Lv et al.

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Natural RNA circles function as efficient microRNA sponges

Thomas B. Hansen et al.

NATURE (2013)

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SYSTEMIC TREATMENT WITH ADIPOSE-DERIVED MESENCHYMAL STEM CELLS AMELIORATES CLINICAL AND PATHOLOGICAL FEATURES IN THE AMYOTROPHIC LATERAL SCLEROSIS MURINE MODEL

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NEUROSCIENCE (2013)

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Dynamic Compaction of Human Mesenchymal Stem/Precursor Cells into Spheres Self-Activates Caspase-Dependent IL1 Signaling to Enhance Secretion of Modulators of Inflammation and Immunity (PGE2, TSG6, and STC1)

Thomas J. Bartosh et al.

STEM CELLS (2013)

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MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

Hongqi Xin et al.

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Microglia activation as a biomarker for traumatic brain injury

Diana G. Hernandez-Ontiveros et al.

FRONTIERS IN NEUROLOGY (2013)

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Donor age and long-term culture affect differentiation and proliferation of human bone marrow mesenchymal stem cells

Merve Zaim et al.

ANNALS OF HEMATOLOGY (2012)

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Abnormal microglial-neuronal spatial organization in the dorsolateral prefrontal cortex in autism

John T. Morgan et al.

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Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential

Priya R. Baraniak et al.

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Human Umbilical Cord Mesenchymal Stem Cell Therapy on Neuromyelitis Optica

Zhengjuan Lu et al.

CURRENT NEUROVASCULAR RESEARCH (2012)

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Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells

Shun-Pei Hung et al.

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Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells

Han-Soo Kim et al.

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Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

Peter Connick et al.

LANCET NEUROLOGY (2012)

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Intravenous Mesenchymal Stem Cells Improve Survival and Motor Function in Experimental Amyotrophic Lateral Sclerosis

Antonio Uccelli et al.

MOLECULAR MEDICINE (2012)

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Circulating Mesenchymal Stem Cells Microparticles in Patients with Cerebrovascular Disease

Suk Jae Kim et al.

PLOS ONE (2012)

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Human Mesenchymal Stem/Stromal Cells Cultured as Spheroids are Self-activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti-inflammatory Phenotype

Joni H. Yloestalo et al.

STEM CELLS (2012)

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Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells

Suk Ho Bhang et al.

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Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting

Catalina Betancur

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Bone Marrow Mononuclear Cells Increase Retinal Ganglion Cell Survival and Axon Regeneration in the Adult Rat

Camila Zaverucha-do-Valle et al.

CELL TRANSPLANTATION (2011)

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Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis

Serhiy Forostyak et al.

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Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases

Antonio Uccelli et al.

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The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments

Peter Connick et al.

TRIALS (2011)

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SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion

Xiaolei Liu et al.

PROTEIN & CELL (2011)

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Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

Dimitrios Karussis et al.

ARCHIVES OF NEUROLOGY (2010)

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Injectable biodegradable hydrogels with tunable mechanical properties for the stimulation of neurogenesic differentiation of human mesenchymal stem cells in 3D culture

Li-Shan Wang et al.

BIOMATERIALS (2010)

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Therapeutic window for treatment of cortical ischemia with bone marrow-derived cells in rats

Andreia de Vasconcelos dos Santos et al.

BRAIN RESEARCH (2010)

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Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice

Heejaung Kim et al.

NEUROSCIENCE LETTERS (2010)

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Growth factor regulation of proliferation and survival of multipotential stromal cells

Melanie Rodrigues et al.

STEM CELL RESEARCH & THERAPY (2010)

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Multiple administrations of human marrow stromal cells through cerebrospinal fluid prolong survival in a transgenic mouse model of amyotrophic lateral sclerosis

Cheng Zhang et al.

CYTOTHERAPY (2009)

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Effects of bone-marrow mesenchymal stem cells transplanted into vitreous cavity of rat injured by ischemia/reperfusion

Li Na et al.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2009)

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Cytokines and CNS Development

Benjamin E. Deverman et al.

NEURON (2009)

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Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Do Not Differentiate Into Neural Cell Types or Integrate Into the Retina After Intravitreal Grafting in Neonatal Rats

Andrew J. Hill et al.

STEM CELLS AND DEVELOPMENT (2009)

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Isolation and characterization of mesenchymal stem cells derived from bone marrow of patients with Parkinson's disease

Zhiqing Zhang et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2008)

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Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS

Masatoshi Suzuki et al.

MOLECULAR THERAPY (2008)

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The role of oxygen availability in embryonic development and stem cell function

M. Celeste Simon et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

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Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

A. Vercelli et al.

NEUROBIOLOGY OF DISEASE (2008)

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Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells

Ivana Rosova et al.

STEM CELLS (2008)

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Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS:: limited intraparenchymal migration and survival narrows therapeutic effects

H.-J. Habisch et al.

JOURNAL OF NEURAL TRANSMISSION (2007)

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Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin

Aihua Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)

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Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression

Esther Potier et al.

BONE (2007)

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Autism spectrum disorders: developmental disconnection syndromes

Daniel H. Geschwind et al.

CURRENT OPINION IN NEUROBIOLOGY (2007)

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