Three Months of Glucocorticoids in Rheumatoid Arthritis: A Bridge Too Short?

Article Rheumatology

Low dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomised, double-blind placebo-controlled GLORIA trial

Maarten Boers et al.

Summary: This study compared the effects and side effects of low-dose prednisolone and placebo treatment in elderly patients with active rheumatoid arthritis. The results showed that low-dose prednisolone can reduce disease activity and joint damage, but the side effects also increased by 24%.

ANNALS OF THE RHEUMATIC DISEASES (2022)

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Article Rheumatology

The Story Behind the Use of Glucocorticoids in the Treatment of Rheumatoid Arthritis

Doyt L. Conn

Summary: Cortisone was introduced in 1948 for the treatment of rheumatoid arthritis, leading to significant improvement, with side effects depending on dose and duration. Guidelines from ACR and EULAR emphasize limited use of glucocorticoids and gradual replacement with biologics, although appropriate use can be effective, safe, and cost-effective for early active RA treatment.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2021)

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Article Rheumatology

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

Liana Fraenkel et al.

Summary: This guideline provides updated recommendations for the pharmacologic management of rheumatoid arthritis, including the use of disease-modifying antirheumatic drugs (DMARDs), glucocorticoids, and considerations for high-risk populations. The recommendations are not prescriptive and should be made through a shared decision-making process based on individual values, goals, preferences, and comorbidities.

ARTHRITIS & RHEUMATOLOGY (2021)

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Review Rheumatology