Clinical status of patients 1 year after hospital discharge following recovery from COVID-19: a prospective cohort study

Article Medicine, General & Internal

Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19

Hidde Heesakkers et al.

Summary: The study found that physical, mental, and cognitive symptoms were frequently reported among COVID-19 patients one year after ICU treatment.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Immunology

Twelve-Month Systemic Consequences of Coronavirus Disease 2019 (COVID-19) in Patients Discharged From Hospital: A Prospective Cohort Study in Wuhan, China

Tingting Liu et al.

Summary: This study investigated longitudinal changes in the characteristics of COVID-19 survivors after discharge. Physiological, laboratory, radiological, or electrocardiogram abnormalities, particularly those related to renal, cardiovascular, and liver functions are common in patients who recovered from COVID-19 up to 12 months post-discharge. Symptoms decreased over time, but abnormalities in certain health indicators persisted.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Longevity of seropositivity and neutralizing antibodies in recovered MERS patients: a 5-year follow-up study

Shinhye Cheon et al.

Summary: The study found that the seropositivity rate of recovered MERS patients persisted for a longer duration, while neutralizing antibody titres decreased more rapidly. Patients with severe pneumonia had higher seropositivity rates and longer duration of neutralizing antibody titres.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Review Clinical Neurology

Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis

Lavienraj Premraj et al.

Summary: Neurological and neuropsychiatric symptoms that persist or develop three months after the onset of COVID-19 pose a significant threat to the global healthcare system. A systematic review analyzed data from multiple studies and found that fatigue, cognitive dysfunction, and sleep disturbances were key features of post-COVID-19 syndrome. Psychiatric manifestations such as anxiety and depression were also common and increased in prevalence over time.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2022)

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Article Immunology

Comprehensive Health Assessment 3 Months After Recovery From Acute Coronavirus Disease 2019 (COVID-19)

Bram van den Borst et al.

Summary: This study conducted a comprehensive health assessment on recovered COVID-19 patients from Radboud University Medical Center, Nijmegen, the Netherlands, and found severe problems in multiple health domains. The research revealed that a significant number of discharged patients experienced lung function abnormalities, residual pulmonary parenchymal abnormalities, low exercise capacity, mental and cognitive issues, as well as fatigue. Longer follow-up studies are needed to understand natural trajectories and predictors of complicated long-term recovery paths.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Respiratory System

Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial

Thomas Sonnweber et al.

Summary: A study found that some COVID-19 patients still experienced persistent symptoms and lung function impairment 100 days after the onset of the disease, but there was significant improvement in symptoms and cardiopulmonary status over time.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Respiratory System

Pulmonary function and radiological features 4 months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study

Sabina A. Guler et al.

Summary: The Swiss COVID-19 lung study investigated pulmonary sequelae of COVID-19 in 113 survivors. Severe/critical COVID-19 was associated with significant functional and radiological abnormalities 4 months after infection, potentially due to small-airway and lung parenchymal disease. Systematic follow-up for survivors needs to be evaluated to optimize care for patients recovering from COVID-19.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Infectious Diseases

Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study

Oscar Moreno-Perez et al.

Summary: This study found that Post-acute COVID-19 syndrome was detected in about half of COVID-19 survivors, with mostly mild symptoms. Radiological and spirometric changes were observed in less than 25% of patients, and no baseline clinical features behaved as independent predictors of Post-acute COVID-19 syndrome development.

JOURNAL OF INFECTION (2021)

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Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

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Article Respiratory System

A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations

Aditi S. Shah et al.

Summary: The long-term respiratory morbidity of COVID-19 remains unclear. A study found that a significant percentage of previously hospitalized patients had persisting abnormalities in clinical, radiological, and pulmonary function, highlighting the importance of developing treatment strategies and long-term respiratory follow-up.

THORAX (2021)

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Article Medicine, General & Internal

Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge

Mattia Bellan et al.

Summary: The study examined the prevalence of lung function, exercise function, and psychological sequelae among survivors of severe COVID-19 four months after discharge. Over half of patients experienced reduced lung capacity, one-fifth had functional impairment, and about one-fifth showed symptoms of posttraumatic stress. These findings suggest that a significant proportion of COVID-19 survivors may continue to experience respiratory, functional, or psychological issues months after hospital discharge.

JAMA NETWORK OPEN (2021)

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Article Critical Care Medicine

Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19 A 3-Month Prospective Cohort

Jessica Gonzalez et al.

Summary: The study investigated the long-term pulmonary sequelae in critical patients who survived COVID-19, finding that structural abnormalities and functional impairment were highly prevalent in these patients three months after discharge, indicating the need for pulmonary evaluation in all critical COVID-19 survivors.

CHEST (2021)

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Article Medicine, General & Internal

Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19

James Nugent et al.

Summary: In this retrospective cohort study, COVID-19-associated AKI was found to be associated with a greater rate of eGFR decrease after discharge compared with AKI in patients without COVID-19. This highlights the importance of monitoring kidney function and studying interventions to limit kidney disease after COVID-19-associated AKI.

JAMA NETWORK OPEN (2021)

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Article Medicine, General & Internal

Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19

Luc Morin et al.

Summary: After 4 months of hospitalization for COVID-19, a significant proportion of patients reported new symptoms and abnormalities in lung scans were common. Further research is needed to understand the long-term consequences of COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection

Bo Diao et al.

Summary: It has been found that SARS-CoV-2 can directly infect human kidneys, leading to tubular pathogenesis and acute kidney injury (AKI). Elderly patients and those with comorbidities like hypertension and heart failure are more susceptible to AKI.

NATURE COMMUNICATIONS (2021)

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Article Medicine, General & Internal

Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study

Daniel Ayoubkhani et al.

Summary: Patients discharged from the hospital after COVID-19 were found to have increased rates of multiorgan dysfunction, with higher risk not only limited to the elderly but also varying across ethnic groups.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Critical Care Medicine

3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study

Xiaojun Wu et al.

Summary: Most patients recovering from severe COVID-19 showed improvement in dyspnoea scores and exercise capacity over time, but a subgroup of patients still exhibited persistent physiological and radiographic changes at 12 months post-discharge. A unified pathway for respiratory follow-up is needed for COVID-19 patients.

LANCET RESPIRATORY MEDICINE (2021)

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Article Medicine, General & Internal

1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study

Lixue Huang et al.

LANCET (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

Jackson S. Turner et al.

Summary: The study found that individuals who had recovered from mild SARS-CoV-2 infections showed rapid decline of serum anti-SARS-CoV-2 spike protein antibodies in the first 4 months after infection, followed by a more gradual decrease over the following 7 months but remaining detectable at least 11 months after infection. This suggests that mild infection with SARS-CoV-2 can induce robust antigen-specific, long-lived humoral immune memory in humans.

NATURE (2021)

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Review Behavioral Sciences

Anxiety, depression, trauma-related, and sleep disorders among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis

Maxime Marvaldi et al.

Summary: This study investigated the prevalence of mental health problems among healthcare workers during the COVID-19 pandemic, finding high rates of anxiety, depression, stress, post-traumatic stress, and sleep disorders. Factors such as proportion of females, nurses, and location were identified as sources of heterogeneity. Targeted prevention and support strategies are necessary in current and future health crises.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

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Article Medicine, General & Internal