3.9 Article

High-Throughput Screening of Epigenetic Inhibitors in Meningiomas Identifies HDAC, G9a, and Jumonji-Domain Inhibition as Potential Therapies

Related references

Note: Only part of the references are listed.
Article Oncology

H3K27me3 loss indicates an increased risk of recurrence in the Tubingen meningioma cohort

Felix Behling et al.

Summary: Loss of H3K27me3 combined with MIB1 labeling index are independent prognostic factors in meningioma. Other prognostic factors, except age and tumor location, remained significant in the multivariate model. Furthermore, adjuvant radiotherapy was an independent positive prognostic factor.

NEURO-ONCOLOGY (2021)

Article Oncology

FLT3 inhibitor lestaurtinib plus chemotherapy for newly diagnosed KMT2A-rearranged infant acute lymphoblastic leukemia: Children's Oncology Group trial AALL0631

Patrick A. Brown et al.

Summary: Adding lestaurtinib did not improve event-free survival overall for infants with KMT2A-rearranged acute lymphoblastic leukemia, but patients who achieved potent FLT3 inhibition and had leukemia blasts sensitive to FLT3 inhibition ex vivo did benefit from the addition of lestaurtinib. Patient selection and pharmacodynamics-guided dose escalation may enhance the efficacy of FLT3 inhibition for this subtype of infant ALL.

LEUKEMIA (2021)

Article Pathology

The substantial loss of H3K27me3 can stratify risk in grade 2, but not in grade 3 meningioma

Minsun Jung et al.

Summary: The trimethylation of lysine 27 of histone H3 (H3K27me3) is a crucial epigenetic marker in meningioma, especially predicting early recurrence and death for grade 2 patients. However, its significance in grade 3 meningioma is controversial. H3K27me3 could be considered as an ancillary test for risk stratification of grade 2 meningioma patients.

HUMAN PATHOLOGY (2021)

Article Clinical Neurology

Prognostic Value of Histopathological Features and Loss of H3K27me3 Immunolabeling in Anaplastic Meningioma: A Multicenter Retrospective Study

Guillaume Gauchotte et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2020)

Editorial Material Genetics & Heredity

CANCER GENETICS Epigenetic cancer evolution, one cell at a time

Carolina N. Perdigoto

NATURE REVIEWS GENETICS (2019)

Article Clinical Neurology

Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence

Leah M. Katz et al.

ACTA NEUROPATHOLOGICA (2018)

Review Biochemistry & Molecular Biology

Emerging Medical Treatments for Meningioma in the Molecular Era

Fares Nigim et al.

BIOMEDICINES (2018)

Article Multidisciplinary Sciences

Genomic profile of human meningioma cell lines

Yu Mei et al.

PLOS ONE (2017)

Review Clinical Neurology

Genetic and epigenetic alterations in meningiomas

Vasiliki Galani et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2017)

Review Biochemistry & Molecular Biology

Role of Merlin/NF2 inactivation in tumor biology

A. M. Petrilli et al.

ONCOGENE (2016)

Review Clinical Neurology

Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review

Leland Rogers et al.

JOURNAL OF NEUROSURGERY (2015)

Article Oncology

Impaired survival and long-term neurological problems in benign meningioma

Hanna van Alkemade et al.

NEURO-ONCOLOGY (2012)

Article Cell & Tissue Engineering

Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds

Jessica A. DeQuach et al.

TISSUE ENGINEERING PART A (2011)

Article Multidisciplinary Sciences

Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L

R Rong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)