Injectable self-healing hydrogel fabricated from antibacterial carbon dots and e-polylysine for promoting bacteria-infected wound healing

Developing highly efficient pharmaceuticals to eradicate pathogens and facilitate wound healing is of great concern. Despite some cationic carbon dots (CDs) have been used for sterilization, hardly any anionic CDs with antimicrobial activity have appeared. In the present work, we engineered a string of anionic CDs (especially CD31) as valid broad-spectrum bactericides to kill bacteria. Furthermore, CD31 conjugated with e-polylysine (Plys) to construct injectable, and self-healing hydrogel (CD-Plys) that possess the advantages of remarkable broad spectrum antibacterial activity, excellent wound healing ability and satisfied biocompatibility. CD-Plys could dramatically accelerate wound healing with epithelization and enhanced angiogenesis. Taken together, this work provides a two-pronged strategy to explore CDs-based antimicrobial agents for disease therapy and tissue engineering.

Automated summary

This study discovered anionic carbon dots with antimicrobial activity and applied them in disease therapy and tissue engineering. By constructing a self-healing hydrogel through conjugation with e-polylysine, these carbon dots can significantly accelerate wound healing and possess broad spectrum antibacterial activity.