4.2 Article

Efficient dermal delivery of ascorbic acid 2-glucoside with photoacoustic waves

Journal

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
Volume 44, Issue 4, Pages 453-463

Publisher

WILEY
DOI: 10.1111/ics.12793

Keywords

delivery; formulation; permeation; photoacoustic waves; skin barrier; vitamin C

Funding

  1. Fundacao para a Ciencia e a Tecnologia [UIDB/00313/2020]
  2. PT2020/COMPETE [39704]

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This study developed a 2% AA2G gel formulation and enhanced the dermal delivery of AA2G using photoacoustic waves. The photoacoustic waves transiently increased skin permeability and improved the delivery of AA2G to the skin.
Objective Ascorbic acid (i.e., vitamin C) is an important antioxidant present in skin. The protective role of vitamin C against photoaging motivated numerous attempts to promote its topical delivery, with a success limited by its chemical instability and poor skin permeability. Vitamin C precursors, such as ascorbic acid 2-glucoside (AA2G), which are metabolized to vitamin C by enzymes present in the skin, solve the problem of stability but are limited by low skin permeability. We developed a 2% (w/v) gel formulation of AA2G application (viscosity 4.30 x 10(4) Pa.s, pH 5.94) and compared its passive dermal delivery with the delivery promoted by photoacoustic waves that transiently perturb the skin barrier. Methods Photoacoustic (PA) waves were generated by laser pulses absorbed by piezophotonic (light-to-pressure) transducers. Pig skin samples were exposed to the 2% AA2G formulation alone or combined with 5 min of PA waves. One hour later, AA2G was extracted from the skin and quantified by reverse-phase HPLC. AA2G transdermal fluxes using Franz cells with 760 mu m thick pig skin samples were also measured. Results Photoacoustic waves transiently enhanced skin permeability and increased dermal delivery of AA2G. AA2G was released from the formulation nearly quantitatively (92.6 +/- 6.2%) in 24 h, showing a non-Fickian behaviour controlled by diffusion and swelling. AA2G dermal delivery with exposure for 5 min to PA waves was compared with passive delivery to pig skin. PA waves increased the delivery of AA2G to the skin by a factor of 15-fold with respect to passive delivery, as measured from skin extracts after 1 h of contact of the formulation with the skin. Conclusion Five minutes of exposure to PA waves is a safe and effective method to deliver large quantities of AA2G to the skin.

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