Journal
FRONTIERS IN MICROBIOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2022.945235
Keywords
enteric fever; paratyphoid fever A; vaccine; bivalent vaccine; Salmonella enterica serovar Paratyphi A
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Funding
- National Natural Science Foundation of China [81974299]
- Scientific Research Starting Foundation of The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University [2019119]
- Southwest Medical University - The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University [2018XYLH-017]
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This article reviews the pathogenesis, global burden, infection features, and vaccine development status of paratyphoid fever A, emphasizing the necessity for the development of vaccines against paratyphoid fever A.
Enteric fever is caused by Salmonella enterica serovar Typhi, Salmonella enterica serovar Paratyphi A, B, and C. While S. Typhi remains the primary causative agent of enteric fever, S. Paratyphi A is responsible for an increasing portion of enteric fever incidence. However, the current available vaccines for enteric fever are all developed from S. Typhi, and lack adequate cross immune protection against paratyphoid fever A. Therefore, paratyphoid A vaccines are urgently needed. The present paper reviews the latest progresses in pathogenesis, global burden, infection features of paratyphoid fever A, as well as the status of vaccine development, highlighting the necessity for the development of vaccines against paratyphoid fever A.
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