Mismatches in 16S rRNA Gene Primers: An Area Worth Further Exploring

Article Microbiology

Distinct Changes Occur in the Human Breast Milk Microbiome Between Early and Established Lactation in Breastfeeding Guatemalan Mothers

Emmanuel Gonzalez et al.

Summary: The study found significant changes in bacterial communities in the breast milk microbiome of healthy Guatemalan mothers between early and late lactation stages, including shifts in species composition and differences in functional traits.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Multidisciplinary Sciences

Evaluation of 16S rRNA primer sets for characterisation of microbiota in paediatric patients with autism spectrum disorder

L. Palkova et al.

Summary: Intestinal microbiota serves as a significant marker for reflecting differences in health and disease states, as well as gut-brain axis communication. The choice of DNA amplification primers was found to influence the outcomes of microbiota investigation, highlighting the importance of standardized protocols in research. Different primer sets can detect varying bacterial compositions, suggesting the need for caution when interpreting microbiota sequencing results.

SCIENTIFIC REPORTS (2021)

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Article Gastroenterology & Hepatology

Microbiome as a potential diagnostic and predictive biomarker in severe alcoholic hepatitis

Soon Sun Kim et al.

Summary: Dysbiosis was confirmed in severe alcoholic hepatitis, however, it was alleviated by rifaximin treatment. Taxa associated with severe AH could serve as candidate biomarkers or therapeutic targets.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

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Article Immunology