4.7 Review

Anti-Inflammatory Metabolites in the Pathogenesis of Bacterial Infection

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J. L. Murray et al.

Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.

LANCET (2022)

Review Biotechnology & Applied Microbiology

Targeting cancer metabolism in the era of precision oncology

Zachary E. Stine et al.

Summary: In the past century, there have been significant advancements in targeting cancer metabolism, but progress in the past decade has been limited. Some metabolism-based drugs for cancer have been successfully developed and are in clinical trials. However, consideration of the metabolism of non-cancer cells is crucial for successful treatment of cancer.

NATURE REVIEWS DRUG DISCOVERY (2022)

Review Immunology

The Candidate Antigens to Achieving an Effective Vaccine against Staphylococcus aureus

Hamid Reza Jahantigh et al.

Summary: Staphylococcus aureus is an opportunistic pathogen that poses a serious threat to human health due to its antibiotic resistance. The development of a prophylactic vaccine against this pathogen is crucial but has faced challenges in clinical trials. Efforts are being made to explore multiple antigens and virulence mechanisms to identify suitable candidates for vaccine development.

VACCINES (2022)

Article Cell Biology

Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

Tania Wong Fok Lung et al.

Summary: Kp ST258 induces disease-tolerant immune response through host metabolic activity, leading to persistent infection.

CELL METABOLISM (2022)

Article Immunology

Staphylococcus aureus Multiplexes Death-Effector Deoxyribonucleosides to Neutralize Phagocytes

Eshraq Tantawy et al.

Summary: The study revealed that Adenosine synthase A (AdsA) from Staphylococcus aureus can generate both dAdo and dGuo, two cytotoxic deoxyribonucleosides that increase macrophage cell death. This discovery sheds light on the pathogen's strategy to maximize survival within hosts and may contribute to the development of new therapeutic interventions against multidrug-resistant staphylococci.

FRONTIERS IN IMMUNOLOGY (2022)

Review Medicine, Research & Experimental

The role of itaconate in host defense and inflammation

Christian G. Peace et al.

Summary: Inflammatory stimuli cause metabolic reprogramming in macrophages, particularly in the Krebs cycle, resulting in the accumulation of itaconate and other metabolites. Itaconate plays diverse roles in immunity and inflammation, including inhibiting inflammasome activation and glycolysis, activating anti-inflammatory transcription factors, and exerting anti-inflammatory effects in various disease models.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Immunology

Development of a Chimeric Vaccine Against Pseudomonas aeruginosa Based on the Th17-Stimulating Epitopes of PcrV and AmpC

Ying Wang et al.

Summary: Two novel PA antigens, PcrV and AmpC, were identified in this study to effectively induce Th17-dependent protection. Intranasal immunization enhanced the protective effect of PcrV, and the recombinant protein PVAC was successfully designed to elicit broad protective immunity against PA. These results offer an alternative strategy for developing Th17-based vaccines against PA and other pathogens.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Targeting adenosine and regulatory T cells in cancer immunotherapy

Alexey Churov et al.

Summary: Regulatory T cells (Tregs) exhibit immunosuppressive activity in tumors, reducing the efficiency of anti-tumor immune responses, making them a focus of immunotherapy research. Targeting CD39 and CD73 pharmacologically has been shown to inhibit suppressor cell activity and enhance the efficacy of cancer therapy.

HUMAN IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation

Kira L. Tomlinson et al.

Summary: The authors demonstrate that the pathogen Staphylococcus aureus induces a distinct airway immunometabolic response dominated by the release of itaconate. This metabolite potentiates extracellular polysaccharide synthesis and biofilm formation in S. aureus, potentially facilitating chronic infection.

NATURE COMMUNICATIONS (2021)

Article Immunology

Identifying virulence determinants of multidrug-resistant Klebsiella pneumoniae in Galleria mellonella

Sebastian Bruchmann et al.

Summary: This study explores the infection fitness landscape of Klebsiella pneumoniae through genome-scale fitness profiling of a multidrug-resistant strain in the Galleria mellonella infection model. Surface polysaccharides, siderophores, and other genes were identified as important for infection, with strain-dependent fitness effects. The study also highlights the potential of using G. mellonella as a scalable model to study virulence mechanisms of bacterial pathogens.

PATHOGENS AND DISEASE (2021)

Article Microbiology

A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness

Laura A. Mike et al.

Summary: The study identifies a close relationship between capsule biosynthesis and hypermucoviscosity in Klebsiella pneumoniae, with central metabolism playing a key regulatory role. Certain metabolic genes specifically impact only one of these properties, with genes related to the TCA cycle playing a significant role.

PLOS PATHOGENS (2021)

Article Oncology

Itaconate ameliorates methicillin-resistant Staphylococcus aureus-induced acute lung injury through the Nrf2/ARE pathway

Gang Liu et al.

Summary: The study demonstrates that treatment with 4-OI can effectively protect mice from acute lung injury induced by MRSA, reducing inflammation, neutrophil infiltration, and lung bacterial burden. The mechanism of action may be related to the activation of the Nrf2 pathway.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Immunology

Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity

Daniele Carvalho Nascimento et al.

Summary: Adenosine signaling through CD39(hi) plasmablasts plays a critical role in sepsis-induced immunosuppression, leading to increased risk of secondary infections. CD39(hi) plasmablasts enhance adenosine accumulation, impairing macrophage bactericidal activity and promoting interleukin-10 production, contributing to immune suppression post-sepsis.

IMMUNITY (2021)

Article Medicine, General & Internal

Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity

Jian Deng et al.

Summary: The study demonstrates that the Staphylococcus aureus virulence factor AdsA alters Th17 responses by interfering with NLRP3 inflammasome-mediated IL-1 beta production, dampening Th1/Th17 immunity and promoting recurrent S. aureus infections. These findings provide important insights for therapeutic and vaccination strategies against S. aureus infections.

EBIOMEDICINE (2021)

Article Cell Biology

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

Sukhvinder Singh et al.

Summary: The study shows that the itaconate/Irg1 axis regulates inflammation in the eye, protecting against tissue damage during bacterial infection through activation of specific signaling pathways and inhibition of inflammasome. This discovery provides evidence for using itaconate in combination with antibiotics to treat bacterial endophthalmitis.

CELL REPORTS MEDICINE (2021)

Article Pharmacology & Pharmacy

Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms

Duy-Khiet Ho et al.

PHARMACEUTICS (2020)

Article Multidisciplinary Sciences

Adenosine and ATPγS protect against bacterial pneumonia-induced acute lung injury

Christine M. Gross et al.

SCIENTIFIC REPORTS (2020)

Article Immunology

Canonical and non-canonical adenosinergic pathways

E. Ferretti et al.

IMMUNOLOGY LETTERS (2019)

Article Biochemistry & Molecular Biology

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

Wei Qin et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Multidisciplinary Sciences

An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism

Hua Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Cell Biology

CFTR-PTEN-dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection

Sebastian A. Riquelme et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Immunology

Purinergic Signaling in Pulmonary Inflammation

Thanh-Thuy T. Le et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Cardiac & Cardiovascular Systems

Inhibition of LPS-stimulated ecto-adenosine deaminase attenuates endothelial cell activation

Barbara Kutryb-Zajac et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)

Review Biochemistry & Molecular Biology

Klebsiella pneumoniae capsule polysaccharide as a target for therapeutics and vaccines

Clement Opoku-Temeng et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2019)

Article Immunology

Irg1 expression in myeloid cells prevents immunopathology during M-tuberculosis infection

Sharmila Nair et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Review Immunology

The Hypoxia-Adenosine Link during Intestinal Inflammation

Jessica L. Bowser et al.

JOURNAL OF IMMUNOLOGY (2018)

Review Physiology

PHARMACOLOGY OF ADENOSINE RECEPTORS: THE STATE OF THE ART

Pier Andrea Borea et al.

PHYSIOLOGICAL REVIEWS (2018)

Article Multidisciplinary Sciences

Staphylococcus aureus targets the purine salvage pathway to kill phagocytes

Volker Winstel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Medicine, Research & Experimental

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

Jonathan M. Weiss et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Multidisciplinary Sciences

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills et al.

NATURE (2018)

Article Pharmacology & Pharmacy

A2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPK kinase pathway

Stefania Merighi et al.

PHARMACOLOGICAL RESEARCH (2017)

Article Biochemistry & Molecular Biology

Adenosine reduces reactive oxygen species and interleukin-8 production by Trichomonas vaginalis-stimulated neutrophils

Amanda Piccoli Frasson et al.

PURINERGIC SIGNALLING (2017)

Article Biotechnology & Applied Microbiology

Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus

Mei Chen et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

Thekla Cordes et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Medicine, Research & Experimental

Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection

Danielle Ahn et al.

JCI INSIGHT (2016)

Article Physiology

Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury

Joyce N. Gonzales et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

Bacterial itaconate degradation promotes pathogenicity

Jahminy Sasikaran et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Cell Biology

Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages

Balazs Koscso et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2013)

Article Multidisciplinary Sciences

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Alessandro Michelucci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

CD39 and CD73 in immunity and inflammation

Luca Antonioli et al.

TRENDS IN MOLECULAR MEDICINE (2013)

Article Critical Care Medicine

Adenosine A2B Receptor Deficiency Promotes Host Defenses against Gram-Negative Bacterial Pneumonia

Kathryn E. Barletta et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

Article Biochemistry & Molecular Biology

Pa0148 from Pseudomonas aeruginosa Catalyzes the Deamination of Adenine

Alissa M. Goble et al.

BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Enzymatic properties of Staphylococcus aureus adenosine synthase (AdsA)

Vilasack Thammavongsa et al.

BMC BIOCHEMISTRY (2011)

Article Chemistry, Multidisciplinary

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

Cheryl L. Strelko et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Immunology

Staphylococcus aureus synthesizes adenosine to escape host immune responses

Vilasack Thammavongsa et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)