Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2022.922511
Keywords
COVID-19; ferroptosis; liver; SARS-CoV-2; hyperferritinemia
Categories
Funding
- Scientific Research Fund of Zhejiang Provincial Education Department [Y202043882]
- Jiaxing Key Laboratory of Virus-Mediated Infectious Diseases [2021-bdzdsys]
- Jiaxing Research Institute of Hepatology [jxsgbyjs]
- Jiaxing Key Supporting Discipline of Medicine [2019-zc-02]
- Program of the First Hospital of Jiaxing [2021-YA-001]
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This review discusses the pathological changes in liver injury caused by COVID-19 and proposes ferroptosis as a potential mechanism. The therapeutic potential of targeting ferroptosis in COVID-19-related liver injury is also examined. Advancements in these areas will enhance our understanding of strategies to prevent and treat COVID-19-induced hepatic injuries.
The outbreak and worldwide spread of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a threat to global public health. SARS-CoV-2 infection not only impacts the respiratory system but also causes hepatic injury. Ferroptosis, a distinct iron-dependent form of non-apoptotic cell death, has been investigated in various pathological conditions, such as cancer, ischemia/reperfusion injury, and liver diseases. However, whether ferroptosis takes part in the pathophysiological process of COVID-19-related liver injury has not been evaluated yet. This review highlights the pathological changes in COVID-19-related liver injury and presents ferroptosis as a potential mechanism in the pathological process. Ferroptosis, as a therapeutic target for COVID-19-related liver injury, is also discussed. Discoveries in these areas will improve our understanding of strategies to prevent and treat hepatic injuries caused by COVID-19.
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