Gatekeeping astrocyte identity

Article Biology

Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson's disease

Weizhao Chen et al.

Summary: This study confirms that repressing PTBP1 does not convert astrocytes to dopaminergic neurons (DAns), regardless of physiological or Parkinson's disease-related pathological conditions.

ELIFE (2022)

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Article Biochemistry & Molecular Biology

Revisiting astrocyte to neuron conversion with lineage tracing in vivo

Lei-Lei Wang et al.

Summary: Recent studies have shown that in vivo cell fate conversions may not actually be converting astrocytes into neurons, but instead utilizing endogenous neurons. Lineage tracing strategies are necessary to accurately track the origin of converted cells, highlighting the importance of applying stringent tracing techniques in studies of cell fate conversions in vivo.

CELL (2021)

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Article Neurosciences

Neuronal replacement: Concepts, achievements, and call for caution

Magdalena Goetz et al.

Summary: Regenerative approaches have advanced towards replacing lost neurons due to injury or neurodegeneration. Identifying molecular programs for neuronal subtype specification and ensuring proper connectivity remain challenges in achieving functional restoration of neuronal networks.

CURRENT OPINION IN NEUROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology