Journal
ELIFE
Volume 11, Issue -, Pages -Publisher
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.74443
Keywords
COVID-19; SARS-CoV-2; macrophage polarization; efferocytosis; hyperinflammation; tissue repair; Human
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2018/25559-4]
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This study reveals that the engulfment of SARS-CoV-2-infected apoptotic cells by macrophages exacerbates inflammatory cytokine production and impairs the ability of macrophages to perform continual efferocytosis. Lung monocytes and macrophages from severe COVID-19 patients also show compromised efferocytic capacity.
COVID-19 is a disease of dysfunctional immune responses, but the mechanisms triggering immunopathogenesis are not established. The functional plasticity of macrophages allows this cell type to promote pathogen elimination and inflammation or suppress inflammation and promote tissue remodeling and injury repair. During an infection, the clearance of dead and dying cells, a process named efferocytosis, can modulate the interplay between these contrasting functions. Here, we show that engulfment of SARS-CoV-2-infected apoptotic cells exacerbates inflammatory cytokine production, inhibits the expression of efferocytic receptors, and impairs continual efferocytosis by macrophages. We also provide evidence supporting that lung monocytes and macrophages from severe COVID-19 patients have compromised efferocytic capacity. Our findings reveal that dysfunctional efferocytosis of SARS-CoV-2-infected cell corpses suppresses macrophage anti-inflammation and efficient tissue repair programs and provides mechanistic insights for the excessive production of pro-inflammatory cytokines and accumulation of tissue damage associated with COVID-19 immunopathogenesis.
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