Related references
Note: Only part of the references are listed.Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications
Antonieta L. Salguero et al.
ACS CHEMICAL BIOLOGY (2022)
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
Mihaly Varadi et al.
NUCLEIC ACIDS RESEARCH (2022)
The structural basis of PTEN regulation by multi-site phosphorylation
Daniel R. Dempsey et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)
Targeting Akt in cancer for precision therapy
Hui Hua et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)
Highly accurate protein structure prediction with AlphaFold
John Jumper et al.
NATURE (2021)
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation
Linda Truebestein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling
Nam Chu et al.
ELIFE (2020)
The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism
Gerta Hoxhaj et al.
NATURE REVIEWS CANCER (2020)
Targeting PI3K in cancer: mechanisms and advances in clinical trials
Jing Yang et al.
MOLECULAR CANCER (2019)
Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics
Andras Boeszoermenyi et al.
NATURE METHODS (2019)
Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity
Lena Quambusch et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Targeting AKT for cancer therapy
Maryam Shariati et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2019)
AKTivation mechanisms
Philip A. Cole et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)
Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity
Nileeka Balasuriya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms
Daniel R. Dempsey et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Targeting the PI3K pathway in cancer: are we making headway?
Filip Janku et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
Yu-Ru Lee et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Conformational sampling of membranes by Akt controls its activation and inactivation
Iva Lucic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis
Nam Chu et al.
CELL (2018)
Optimal control theory enables homonuclear decoupling without Bloch-Siegert shifts in NMR spectroscopy
Paul W. Coote et al.
NATURE COMMUNICATIONS (2018)
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
Michael Ebner et al.
MOLECULAR CELL (2017)
Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis
Brian P. Weiser et al.
BIOPHYSICAL JOURNAL (2017)
AKT/PKB Signaling: Navigating the Network
Brendan D. Manning et al.
CELL (2017)
Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles
Michael T. Marty et al.
ANALYTICAL CHEMISTRY (2015)
SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity
Kyle J. Seamon et al.
NUCLEIC ACIDS RESEARCH (2015)
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
Pengda Liu et al.
NATURE (2014)
Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer
Parthasarathy Seshacharyulu et al.
CANCER LETTERS (2013)
Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis
David Bolduc et al.
ELIFE (2013)
Discovery and Optimization of a Series of 3-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: Orally Bioavailable, Selective, and Potent ATP-Independent Akt Inhibitors
Mark A. Ashwell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers
Chaitali Parikh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt
Kui Lin et al.
SCIENCE SIGNALING (2012)
Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane
Jie Wang et al.
BIOLOGY OPEN (2012)
Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity
Tung O. Chan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition
Wen-I Wu et al.
PLOS ONE (2010)
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation
Kajsa Ericson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PTEN and the PI3-Kinase Pathway in Cancer
Nader Chalhoub et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)
In Vitro Enzymatic Characterization of Near Full Length EGFR in Activated and Inhibited States
Chen Qiu et al.
BIOCHEMISTRY (2009)
Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition
Veronique Calleja et al.
PLOS BIOLOGY (2009)
Molecular Mechanism of an Oncogenic Mutation That Alters Membrane Targeting: Glu17Lys Modifies the PIP Lipid Specificity of the AKT1 PH Domain
Kyle E. Landgraf et al.
BIOCHEMISTRY (2008)
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55α regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt
Yi-Chun Kuo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Combined chemical shift changes and amino acid specific chemical shift mapping of protein-protein interactions
Frank H. Schumann et al.
JOURNAL OF BIOMOLECULAR NMR (2007)
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
John D. Carpten et al.
NATURE (2007)
Kinetic mechanism of AKT/PKB enzyme family
Xiaoling Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The CCPN data model for NMR spectroscopy: Development of a software pipeline
WF Vranken et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)
Optimal electric fields for different sample shapes in high resolution NMR spectroscopy
TM de Swiet
JOURNAL OF MAGNETIC RESONANCE (2005)
PHLPP: A phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth
TY Gao et al.
MOLECULAR CELL (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
J Yang et al.
NATURE STRUCTURAL BIOLOGY (2002)
Share Paper
