4.8 Article

Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

Related references

Note: Only part of the references are listed.
Article Biology

Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus

Henrique Machado et al.

Summary: Henrique Machado and colleagues describe mutational mechanisms associated with MRSA vancomycin resistance in Staphylococcus aureus using adaptive laboratory evolution experiments focused on tolerance. Their results reveal environment-dependent mutational strategies to vancomycin tolerization and the impact of mutations in regulatory genes, providing insight into the development of antibiotic resistance under multiple conditions.

COMMUNICATIONS BIOLOGY (2021)

Article Critical Care Medicine

Polyclonality, Shared Strains, and Convergent Evolution in Chronic Cystic Fibrosis Staphylococcus aureus Airway Infection

Dustin R. Long et al.

Summary: This study characterized the molecular epidemiology and genetic adaptation of Staphylococcus aureus in chronic CF airway infection, revealing that patients often carry multiple, genetically distinct S. aureus lineages with adaptations in persistence and antimicrobial resistance genes. Limited strain-sharing was identified among patients, and S. aureus genetic diversity was found to be unconstrained, suggesting the need for novel diagnostic and therapeutic approaches in the future.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Article Immunology

YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus

Atmika Paudel et al.

Summary: This study showed that introducing the yjbH gene instead of the yjbI gene restored virulence in both silkworms and mice in Staphylococcus aureus mutants; yjbH, downstream to yjbI in a two-gene operon yjbIH, was responsible for this restoration of virulence; disruption of yjbI and yjbH genes resulted in differential gene expression and significant downregulation of virulence-related genes.

VIRULENCE (2021)

Article Multidisciplinary Sciences

Clinically relevant mutations in core metabolic genes confer antibiotic resistance

Allison J. Lopatkin et al.

Summary: The study discovered that Escherichia coli undergo metabolic changes when adapting to antibiotics, with some noncanonical genes implicated in antibiotic resistance. These metabolic alterations lead to decreased basal respiration, avoiding metabolic toxicity and reducing drug lethality. Additionally, some metabolism-specific mutations identified are overrepresented in the genomes of >3500 clinical E. coli pathogens, indicating clinical relevance.

SCIENCE (2021)

Article Microbiology

Distinct clonal lineages and within-host diversification shape invasive Staphylococcus epidermidis populations

Anna Both et al.

Summary: S. epidermidis demonstrates multifactorial processes of infection adaptation, including intra-clonal heterogeneity, mutations and deletions in specific genes, and enhanced biofilm formation. This adaptive process allows invasive S. epidermidis to survive in hostile environments and progress to chronic implant-associated infections.

PLOS PATHOGENS (2021)

Article Biology

In-host population dynamics of Mycobacterium tuberculosis complex during active disease

Roger Vargas et al.

Summary: This study investigated the population dynamics of Mycobacterium tuberculosis complex (Mtbc) in-host using longitudinally collected clinical Mtbc isolates from 200 patients, revealing Mtbc diversity during active TB disease and the development of new resistance mutations between sampling in some patients. The research also found that low abundance resistance variants in the first sample may predict fixation in subsequent samples.

ELIFE (2021)

Article Multidisciplinary Sciences

Stepwise pathogenic evolution of Mycobacterium abscessus

Josephine M. Bryant et al.

Summary: The study suggests that epigenetic modifiers acquired through horizontal gene transfer can lead to sudden increases in the pathogenic potential of specific environmental clones, while allopatric parallel evolution during chronic lung infection promotes rapid increases in virulence. The findings indicate that constrained pathogenic evolution is observed while person-to-person transmission remains indirect.

SCIENCE (2021)

Article Multidisciplinary Sciences

Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

Rachel Wheatley et al.

Summary: This study reveals how host immunity and natural selection interact to drive the rapid changes in antibiotic resistance during infection. The development and decrease of resistant strains post-treatment result in dynamic changes in antibiotic resistance during the infection process.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Common Adaptive Strategies Underlie Within-Host Evolution of Bacterial Pathogens

Yair E. Gatt et al.

Summary: Within-host adaptation in chronic bacterial infections involves substantial genomic changes. Different species share common adaptive strategies, often driven by the host immune system. The ubiquity of adaptive strategies across species reveals key evolutionary changes.

MOLECULAR BIOLOGY AND EVOLUTION (2021)

Article Biochemistry & Molecular Biology

IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era

Bui Quang Minh et al.

MOLECULAR BIOLOGY AND EVOLUTION (2020)

Article Microbiology

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

Aleksandra Petrovic Fabijan et al.

NATURE MICROBIOLOGY (2020)

Article Multidisciplinary Sciences

Evolution of vancomycin-resistant Enterococcus faecium during colonization and infection in immunocompromised pediatric patients

Gayatri Shankar Chilambi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation

Chrispin Chaguza et al.

NATURE COMMUNICATIONS (2020)

Article Genetics & Heredity

Impact of insertion sequences on convergent evolution of Shigella species

Jane Hawkey et al.

PLOS GENETICS (2020)

Article Multidisciplinary Sciences

Effect of tolerance on the evolution of antibiotic resistance under drug combinations

Jiafeng Liu et al.

SCIENCE (2020)

Letter Infectious Diseases

Genomic characterization of inpatient evolution of MRSA resistant to daptomycin, vancomycin and ceftaroline

Daniel Wuthrich et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2019)

Article Multidisciplinary Sciences

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

Mariya Goncheva et al.

NATURE COMMUNICATIONS (2019)

Article Evolutionary Biology

Within-Host Adaptation Mediated by Intergenic Evolution in Pseudomonas aeruginosa

S. M. Hossein Khademi et al.

GENOME BIOLOGY AND EVOLUTION (2019)

Article Microbiology

MprF-mediated daptomycin resistance

Christoph M. Ernst et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2019)

Article Multidisciplinary Sciences

Epistasis between antibiotic tolerance, persistence, and resistance mutations

Irit Levin-Reisman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

The purine biosynthesis regulator PurR moonlights as a virulence regulator in Staphylococcus aureus

William E. Sause et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Microbiology

Immunity to Staphylococcus aureus: Implication for Vaccine Development

Richard A. Proctor

MICROBIOLOGY SPECTRUM (2019)

Article Multidisciplinary Sciences

Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections

Romain Guerillot et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Immunology

Staphylococcus aureus Small Colony Variants (SCVs): News From a Chronic Prosthetic Joint Infection

Guilherme Loss et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Improved metagenomic analysis with Kraken 2

Derrick E. Wood et al.

GENOME BIOLOGY (2019)

Article Microbiology

AureoWiki-The repository of the Staphylococcus aureus research and annotation community

Stephan Fuchs et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2018)

Article Infectious Diseases

PBP4 activity and its overexpression are necessary for PBP4-mediated high-level beta-lactam resistance

Li Basuino et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)

Article Dermatology

The Microevolution and Epidemiology of Staphylococcus aureus Colonization during Atopic Eczema Disease Flare

Catriona P. Harkins et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Article Biochemistry & Molecular Biology

PANNZER2: a rapid functional annotation web server

Petri Toronen et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Immunology

Mutation of Agr Is Associated with the Adaptation of Staphylococcus aureus to the Host during Chronic Osteomyelitis

Carlos M. Suligoy et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2018)

Article Immunology

Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection

Deena R. Altman et al.

INFECTION AND IMMUNITY (2018)

Article Genetics & Heredity

Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)

Romain Guerillot et al.

GENOME MEDICINE (2018)

Article Biotechnology & Applied Microbiology

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Maho Yokoyama et al.

GENOME BIOLOGY (2018)

Article Multidisciplinary Sciences

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Christopher Abbosh et al.

NATURE (2017)

Review Microbiology

The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota

Bernhard Krismer et al.

NATURE REVIEWS MICROBIOLOGY (2017)

Article Microbiology

PaperBLAST: Text Mining Papers for Information about Homologs

Morgan N. Price et al.

MSYSTEMS (2017)

Article Biochemistry & Molecular Biology

Universal Patterns of Selection in Cancer and Somatic Tissues

Inigo Martincorena et al.

Article Immunology

Identification and treatment of the Staphylococcus aureus reservoir in vivo

Bas G. J. Surewaard et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Article Statistics & Probability

cooccur: Probabilistic Species Co-Occurrence Analysis inR

Daniel M. Griffith et al.

Journal of Statistical Software (2016)

Article Biochemistry & Molecular Biology

Genomic diversity in autopsy samples reveals within-host dissemination of HIV-associated Mycobacterium tuberculosis

Tami D. Lieberman et al.

NATURE MEDICINE (2016)

Review Microbiology

Within-host evolution of bacterial pathogens

Xavier Didelot et al.

NATURE REVIEWS MICROBIOLOGY (2016)

Article Genetics & Heredity

SNP-sites: rapid efficient extraction of SNPs from multi-FASTA alignments

Andrew J. Page et al.

MICROBIAL GENOMICS (2016)

Article Biochemical Research Methods

CNOGpro: detection and quantification of CNVs in prokaryotic whole-genome sequencing data

Ola Brynildsrud et al.

BIOINFORMATICS (2015)

Review Microbiology

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

Steven Y. C. Tong et al.

CLINICAL MICROBIOLOGY REVIEWS (2015)

Article Multidisciplinary Sciences

Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission

Gavin K. Paterson et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Evolutionary Trade-Offs Underlie the Multifaceted Virulence of Staphylococcus aureus

Maisem Laabei et al.

PLOS BIOLOGY (2015)

Article Microbiology

Analysis of Bottlenecks in Experimental Models of Infection

Soeren Abel et al.

PLOS PATHOGENS (2015)

Article Genetics & Heredity

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

Rasmus Lykke Marvig et al.

NATURE GENETICS (2015)

Article Biochemical Research Methods

Prokka: rapid prokaryotic genome annotation

Torsten Seemann

BIOINFORMATICS (2014)

Article Microbiology

Development of Oxacillin Resistance in a Patient with Recurrent Staphylococcus aureus Bacteremia

Eileen M. Burd et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2014)

Review Microbiology

Reductive genome evolution at both ends of the bacterial population size spectrum

Berenice Batut et al.

NATURE REVIEWS MICROBIOLOGY (2014)

Article Microbiology

Antibiotic-Induced Autoactivation of IS256 in Staphylococcus aureus

Franziska Schreiber et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

Article Microbiology

Decreased Vancomycin Susceptibility in Staphylococcus aureus Caused by IS256 Tempering of WalKR Expression

Christopher R. E. McEvoy et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

Article Multidisciplinary Sciences

Within-Host Evolution of Staphylococcus aureus during Asymptomatic Carriage

Tanya Golubchik et al.

PLOS ONE (2013)

Article Immunology

Nasal Carriage as a Source of agr-Defective Staphylococcus aureus Bacteremia

Davida S. Smyth et al.

JOURNAL OF INFECTIOUS DISEASES (2012)

Review Microbiology

Nutritional immunity: transition metals at the pathogen-host interface

M. Indriati Hood et al.

NATURE REVIEWS MICROBIOLOGY (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Article Multidisciplinary Sciences

Predicting the Functional Effect of Amino Acid Substitutions and Indels

Yongwook Choi et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease

Bernadette C. Young et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Microbiology

New Role of the Disulfide Stress Effector YjbH in β-Lactam Susceptibility of Staphylococcus aureus

Nadine Goehring et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

Review Biochemistry & Molecular Biology

Extraribosomal functions of bacterial ribosomal proteins

L. V. Aseev et al.

MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Estimation of the Neutrality Index

Nina Stoletzki et al.

MOLECULAR BIOLOGY AND EVOLUTION (2011)

Review Microbiology

Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?

Guy E. Thwaites et al.

NATURE REVIEWS MICROBIOLOGY (2011)

Article Multidisciplinary Sciences

Helicobacter pylori genome evolution during human infection

Lynn Kennemann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemical Research Methods

BEDTools: a flexible suite of utilities for comparing genomic features

Aaron R. Quinlan et al.

BIOINFORMATICS (2010)

Review Genetics & Heredity

Evolutionary microbial genomics: insights into bacterial host adaptation

Christina Toft et al.

NATURE REVIEWS GENETICS (2010)

Article Biochemistry & Molecular Biology

MicrobesOnline: an integrated portal for comparative and functional genomics

Paramvir S. Dehal et al.

NUCLEIC ACIDS RESEARCH (2010)

Review Genetics & Heredity

Quorum Sensing in Staphylococci

Richard P. Novick et al.

ANNUAL REVIEW OF GENETICS (2008)

Article Immunology

Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains

Bo Shopsin et al.

JOURNAL OF INFECTIOUS DISEASES (2008)

Review Infectious Diseases

The role of nasal carriage in Staphylococcus aureus infections

HFL Wertheim et al.

LANCET INFECTIOUS DISEASES (2005)

Article Microbiology

Hypermutable and fluoroquinolone-resistant clinical isolates of Staphylococcus aureus

HNG Trong et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)