Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2022, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2022/4271358
Keywords
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Funding
- Royal Physiographic Society of Lund [40616/2019/09/25]
- Anara AB, Trelleborg, Sweden
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The article describes a study on the effects of α-amylase on human neuroblastoma cells. The research shows that α-amylase can inhibit cell proliferation and directly impact glucose uptake, suggesting its potential as an anticancer agent for neuroblastoma treatment.
The present article describes a study of the effects of alpha-amylase (alpha-amylase) on the human neuroblastoma (NB) cell lines SH-SY5Y, IMR-32, and LA-N-1. NB is the most common malignancy diagnosed in infants younger than 12 months. Some clinical observations revealed an inverse association between the risk of NB development and breastfeeding. alpha-Amylase which is present in breast milk was shown to have anticancer properties already in the beginning of the 20th century. Data presented here show that pancreatic alpha-amylase inhibits cell proliferation and has a direct impact on glucose uptake in the human NB cell lines. Our results point out the importance of further research which could elucidate the alpha-amylase mode of action and justify the presence of this enzyme in breast milk as a possible inhibitor of NB development. alpha-Amylase can be thus recognized as a potential safe and natural mild/host anticancer agent minimizing chemotherapy-related toxicity in the treatment of NB.
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