Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 11, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202200416
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Funding
- DST-SERB India [CRG/2020/005542]
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A developed method for C-C coupling reactions allows a wide range of functionalized N-Cbz amides to react with enolizable esters, ketones, and amides to produce 1,3-dicarbonyl compounds under mild conditions. The reactions proceed at room temperature in the presence of LiHMDS in CPME, resulting in good to excellent yields of desired products in a short reaction time.
A wide range of functionalized N-Cbz amides underwent base-promoted C-C coupling reactions with enolizable esters, ketones and amides to afford 1,3-dicarbonyl compounds under mild conditions. The reactions proceeded at room temperature in the presence of LiHMDS in cyclopentyl methyl ether (CPME). The desired beta-ketoesters, beta-keto amides and 1,3-diketones were obtained in good to excellent yields in a short reaction time. Broad substrate scope, functional group tolerance and metal-free conditions are the merits of the developed methodology.
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