4.4 Review

MiRNA biomarkers in cancers of the male reproductive system: Are we approaching clinical application?

Related references

Note: Only part of the references are listed.
Article Oncology

Detection of recurrences using serum miR-371a-3p during active surveillance in men with stage I testicular germ cell tumours

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Summary: MiR-371a-3p can detect recurrence during active surveillance of stage I GCT earlier and more reliably than standard follow-up investigations.

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MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data

Sharmila Rana et al.

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Associations of serum levels of microRNA-371a-3p (M371) with risk factors for progression in nonseminomatous testicular germ cell tumours clinical stage 1

Klaus-Peter Dieckmann et al.

Summary: Postoperatively elevated M371 levels are not associated with risk factors for progression in NS CS1 patients, while preoperative M371 expression is significantly associated with LV1.

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MicroRNAs in Differentiation of Embryoid Bodies and the Teratoma Subtype of Testicular Cancer

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Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-life Study

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Serum Levels of MicroRNA-371a-3p (M371) Can Predict Absence or Presence of Vital Disease in Residual Masses After Chemotherapy of Metastatic Seminoma

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DigiMir Test: Establishing a Novel Pipeline for MiR-371a Quantification Using Droplet Digital PCR in Liquid Biopsies From Testicular Germ Cell Tumor Patients

Jose Pedro Sequeira et al.

Summary: Testicular germ cell tumors (TGCTs) are common cancers in young-adult males. Hsa-miR-371a-3p has shown to be a reliable biomarker for diagnosis and monitoring of these tumors. In this study, the researchers developed a ddPCR-based pipeline called DigiMir, which demonstrated superior accuracy in detecting TGCTs compared to other methods.

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Summary: The presence of miR-371 in the cystic fluid of teratoma is somewhat mysterious, as this GCT subtype typically does not express it. Two hypotheses have been proposed to explain this finding, shedding light on the biology of this novel biomarker of GCT.

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Serum levels of microRNA-371a-3p are not elevated in testicular tumours of non-germ cell origin

Gazanfer Belge et al.

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Simona Giglio et al.

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Richard J. Rebello et al.

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Combining Hypermethylated RASSF1A Detection Using ddPCR with miR-371a-3p Testing: An Improved Panel of Liquid Biopsy Biomarkers for Testicular Germ Cell Tumor Patients

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Summary: A combination of miR-371a-3p and hypermethylated RASSF1A in serum samples of testicular germ cell tumor patients showed a sensitivity of 100% in detecting the disease, including teratomas, making it a promising biomarker panel for clinical implementation and patient follow-up.

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Small Extracellular Vesicle-Derived microRNAs Stratify Prostate Cancer Patients According to Gleason Score, Race and Associate with Survival of African American and Caucasian Men

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Summary: Novel sEV-associated miRs, including miR-6068 and miR-1915-3p, were found to be enriched in PCa patients, with miR-6716-5p and miR-3692-3p distinguishing between AA and CA men and low and high Gleason score. Among these miRs, miR-1915-3p emerged as an independent prognostic marker for longer recurrence-free survival.

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MeeYoung Kim et al.

Summary: This study identified differential expression of urinary exosomal miRNAs in patients with biochemical recurrence of intermediate-risk prostate cancer, with miR-532-5p being an important predictive factor. The upregulation of miR-532-5p suggests its potential as a biomarker for poor prognosis in these patients, warranting further research on its biological functions and mechanisms.

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A Multi-institutional Pooled Analysis Demonstrates That Circulating miR-371a-3p Alone is Sufficient for Testicular Malignant Germ Cell Tumor Diagnosis

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Testicular Cancer in the Cisplatin Era: Causes of Death and Mortality Rates in a Population-Based Cohort

Ragnhild Hellesnes et al.

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