Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 10, Issue 25, Pages 8216-8227Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.2c01992
Keywords
deep eutectic solvent screening; alpha-tocopherol extraction; COSMO-RS; extraction potential estimation; solid-liquid equilibria prediction; phase splitting check; EHS impact assessment; experimental validation
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [SU 189/9-1]
- National Natural Science Foundation of China (NSFC) [21861132019]
- Natural Science Foundation of Shanghai [19ZR1412600]
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This work proposes the use of deep eutectic solvents (DESs) as an alternative approach for the extraction of vitamin E from deodorized distillates. A rational screening method is presented to select suitable DESs, considering thermodynamic evaluation, environmental and safety impacts, and eutectic behavior estimation. The reliability of the screening method is validated through experiments, identifying tetrabutylphosphonium chloride-ethanolamine as a suitable DES for alpha-tocopherol extraction.
As traditional methods for retrieving natural vitamin E suffer from harsh operating conditions and poor process performance, seeking more energy-efficient and sustainable alternative approaches is highly desirable. In this work, deep eutectic solvents (DESs) as a class of emerging media are particularly proposed for the extraction of vitamin E (modeled by alpha-tocopherol) from deodorized distillates under mild operating conditions. To select DESs suitable for this task, a rational screening method is presented which covers the thermodynamic evaluation of individual components and component combinations, the assessment of environment, health, and safety (EHS) impacts of components, and the eutectic behavior estimation of component combinations. Based on experimentally reported DESs from the literature, individual components as well as random combinations of potential hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs) are successively prescreened by COSMO-RS predicted thermodynamic proper-ties. Five EHS-related properties of HBDs are assessed by VEGA. The formation of eutectics and the corresponding operating window of different HBA-HBD combinations are estimated by COSMO-RS solid-liquid equilibria prediction. Experiments are finally performed with the top-ranked DESs, which well validates the reliability of the screening method and identifies tetrabutylphosphonium chloride-ethanolamine (2:1) as a suitable DES for the alpha-tocopherol extraction.
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