Journal
TOXINS
Volume 14, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/toxins14070464
Keywords
Staphylococcus aureus; toxin; inflammatory cells; pyroptosis; apoptosis; necroptosis; autophagy
Categories
Funding
- National Natural Science Foundation of China [82171764, 81871266, 81301948]
- Guangzhou science and technology project [202102010104]
- Natural Science Foundation from Guangdong Science and Technology Department [2021A1515012551]
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Staphylococcus aureus, a common bacterium, plays a crucial role in various diseases. This article discusses its virulence factors, inflammatory responses, host cell death, and associated diseases, highlighting the importance of understanding its pathogenic mechanisms for targeted treatment.
Staphylococcus aureus is a very common Gram-positive bacterium, and S. aureus infections play an extremely important role in a variety of diseases. This paper describes the types of virulence factors involved, the inflammatory cells activated, the process of host cell death, and the associated diseases caused by S. aureus. S. aureus can secrete a variety of enterotoxins and other toxins to trigger inflammatory responses and activate inflammatory cells, such as keratinocytes, helper T cells, innate lymphoid cells, macrophages, dendritic cells, mast cells, neutrophils, eosinophils, and basophils. Activated inflammatory cells can express various cytokines and induce an inflammatory response. S. aureus can also induce host cell death through pyroptosis, apoptosis, necroptosis, autophagy, etc. This article discusses S. aureus and MRSA (methicillin-resistant S. aureus) in atopic dermatitis, psoriasis, pulmonary cystic fibrosis, allergic asthma, food poisoning, sarcoidosis, multiple sclerosis, and osteomyelitis. Summarizing the pathogenic mechanism of Staphylococcus aureus provides a basis for the targeted treatment of Staphylococcus aureus infection.
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