4.7 Article

Development of a Monoclonal scFv against Cytotoxin to Neutralize Cytolytic Activity Induced by Naja atra Venom on Myoblast C2C12 Cells

Related references

Note: Only part of the references are listed.
Article Toxicology

The myth of cobra venom cytotoxin: More than just direct cytolytic actions

Jia Jin Hiu et al.

Summary: This article discusses the interaction between cobra venom cytotoxin (CTX) and the cell membrane, including electrostatic interaction, hydrophobic partitioning, isotropic phase, and oligomerization. Oligomerization of CTX causes pore formation in the cell membrane lipid bilayer, and CTX can induce apoptosis through both extrinsic and intrinsic pathways. The article also discusses lysosomal-mediated necrosis and the occurrence of necroptosis following CTX action. The study provides insights into the concentration-dependent transition of cell death patterns caused by CTX and suggests new directions for further research on cytotoxic pathways and the development of biotherapeutics targeting CTX-induced pathological effects.

TOXICON-X (2022)

Article Immunology

Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2

Shuangshi Wei et al.

Summary: The study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against SARS-CoV-2. Results showed significant neutralizing potency against SARS-CoV-2, various spike protein mutants, and even SARS-CoV in vitro, which might be a feasible tool for the prevention and control of ongoing COVID-19.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Proteomic analysis of three medically important Nigerian Naja (Naja haje, Naja katiensis and Naja nigricollis) snake venoms

Fatima Amin Adamude et al.

Summary: Proteomics technologies were used to study the venom proteomes of three medically important Nigerian Elapidae snakes, revealing common and uncommon proteins in their venoms. The findings provide insights into the composition of venom proteins in these snakes and suggest the potential for cross-neutralizing antivenom.

TOXICON (2021)

Article Toxicology

Reports of Doses Administered and Adverse Reactions to Snake Antivenom Used in Uruguay in 2018

Alba Negrin et al.

Summary: A study in Uruguay analyzed the doses and adverse reactions of snake antivenoms used in 2018, noting that the lyophilized antivenom BIOL (R) had a higher initial dose but effectively neutralized venom with minimal complications. Early adverse reactions were detected in a small number of patients treated with BIOL antivenom, while no adverse reactions were reported with traditional liquid antivenoms.

FRONTIERS IN TOXICOLOGY (2021)

Article Toxicology

Chicken antibodies against venom proteins of Trimeresurus stejnegeri in Taiwan

Chi-Hsin Lee et al.

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES (2020)

Article Pharmacology & Pharmacy

Pros and cons of different therapeutic antibody formats for recombinant antivenom development

Andreas H. Laustsen et al.

TOXICON (2018)

Article Multidisciplinary Sciences

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

Andreas H. Laustsen et al.

NATURE COMMUNICATIONS (2018)

Article Toxicology

Naja atra snakebite in Taiwan

Yan-Chiao Mao et al.

CLINICAL TOXICOLOGY (2018)

Article Biochemical Research Methods

Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca

Line P. Lauridsen et al.

JOURNAL OF PROTEOMICS (2017)

Article Medicine, General & Internal

Snakebite envenoming

Jose Maria Gutierrez et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Biotechnology & Applied Microbiology

Antibodies against Venom of the Snake Deinagkistrodon acutus

Chi-Hsin Lee et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2016)

Review Pharmacology & Pharmacy

Adverse reactions to snake antivenom, and their prevention and treatment

H. Asita de Silva et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2016)

Article Public, Environmental & Occupational Health

Bacteriology of Naja atra Snakebite Wound and Its Implications for Antibiotic Therapy

Yan-Chiao Mao et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2016)

Article Biotechnology & Applied Microbiology

Production and Characterization of Neutralizing Antibodies against Bungarus multicinctus Snake Venom

Chi-Hsin Lee et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2016)

Article Medicine, General & Internal

An investigation of snakebite antivenom usage in Taiwan

Chih-Chuan Lin et al.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2016)

Review Medicine, Research & Experimental

Phage display-derived human antibodies in clinical development and therapy

Andre Frenzel et al.

Review Pharmacology & Pharmacy

Understanding and confronting snakebite envenoming: The harvest of cooperation

Jose Maria Gutierrez

TOXICON (2016)

Editorial Material Dermatology

Antibody Phage Display: Technique and Applications

Christoph M. Hammers et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Review Immunology

Hybridoma technologies for antibody production

Masahiro Tomita et al.

IMMUNOTHERAPY (2011)

Article Pharmacology & Pharmacy

Snakebite envenoming from a global perspective: Towards an integrated approach

Jose Maria Gutierrez et al.

TOXICON (2010)

Article Biochemical Research Methods

Human monoclonal ScFv neutralize lethal Thai cobra, Naja kaouthia, neurotoxin

Kasem Kulkeaw et al.

JOURNAL OF PROTEOMICS (2009)

Article Biotechnology & Applied Microbiology

Outlook - Development trends for monoclonal antibody cancer therapeutics

Janice M. Reichert et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

Review Immunology

Potent antibody therapeutics by design

PJ Carter

NATURE REVIEWS IMMUNOLOGY (2006)

Article Medicine, General & Internal

Confronting the neglected problem of snake bite envenoming: The need for a global partnership

Jose Maria Gutierrez et al.

PLOS MEDICINE (2006)

Article Public, Environmental & Occupational Health

Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG:: an alternative to the antivenom crisis in Africa

JM Gutiérrez et al.

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (2005)

Article Public, Environmental & Occupational Health

Taiwan's venomous snakebite: epidemiological, evolution and geographic differences

DZ Hung

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (2004)

Article Biochemical Research Methods

Methods for the generation of chicken monoclonal antibody fragments by phage display

J Andris-Widhopf et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2000)

Review Hematology

Introduction to antibody engineering and phage display

NA Watkins et al.

VOX SANGUINIS (2000)