Journal
POLYMERS
Volume 14, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/polym14132593
Keywords
oncology; cardiovascular diseases; biodegradable polymers; monoclonal antibodies; drug release kinetics
Categories
Funding
- [100024-2020-RC-CURIOSITY_ 001-Campardelli-CUP: D39C20000510005]
Ask authors/readers for more resources
This study compares the performance of three different biocompatible and biodegradable polymers for the production of microparticles for drug delivery. The characteristics of the microparticles, release of the drug, and cell viability were investigated.
This work is a comparative study among three different biocompatible and biodegradable polymers, poly(lactic-co-glycolic acid), poly(epsilon-caprolactone), and poly(lactic acid), used to produce microparticles for the encapsulation of bevacizumab for drug delivery purposes. All the formulations were produced using the double emulsion water-oil-water evaporation method and characterized in terms of particle mean diameter, particle size distribution, and bevacizumab entrapment efficiency. Bevacizumab cumulative release was taken into consideration to study the dissolution kinetics from the three different polymeric delivery platforms for a period of 50 days at 37 degrees C in phosphate buffered saline and mathematical models of the drug release kinetic were attempted in order to describe the release phenomena from the different types of the studied microparticles. Finally, cell viability on human endothelial cell line EA.hy926 was studied to define the maximum cytocompatible concentration for each microsystem, registering the mitochondrial functionality through MTS assay.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available