4.7 Article

Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling

Selma E. Anton et al.

Summary: Cells use independent cAMP nanodomains to send different signals, which form self-sufficient cell signaling units. Each nanodomain contains a highly localized cAMP pool that is protected from other receptors and cell compartments. The gradients of local cAMP concentrations define the size of each individual nanodomain. The coexistence of many such nanodomains allows a single cell to operate multiple independent cellular signals simultaneously.
Article Immunology

Pertussis Toxin Promotes Pulmonary Hypertension in an Infant Mouse Model of Bordetella pertussis Infection

Karen M. Scanlon et al.

Summary: The study revealed that Bordetella pertussis-induced pulmonary hypertension is age-related and depends on the expression of pertussis toxin by the bacterium. Targeting pertussis toxin in treatment may help alleviate pulmonary hypertension and fatal infant infections.

JOURNAL OF INFECTIOUS DISEASES (2022)

Article Biochemistry & Molecular Biology

Selective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of Bordetella pertussis

Jana Holubova et al.

Summary: The whooping cough agent, Bordetella pertussis, secretes a toxin-hemolysin that affects host cells by increasing cAMP levels and forming pores, however, enhancing or reducing the pore-forming activity does not significantly alter its virulence in mice.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage

Violaine Dubois et al.

Summary: The study found that the acellular pertussis vaccine (aPV) prolonged nasal carriage of Bordetella pertussis (Bp) in mice, compared to the whole-cell pertussis vaccine (wPV), by inhibiting the natural induction of key T cells essential for clearing nasal infection. This inhibition of T cell response by aPV may have led to the resurgence of pertussis by augmenting the Bp reservoir and hindering neutrophil recruitment essential for clearing the bacteria.

NPJ VACCINES (2021)

Review Immunology

Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host

Thomas Belcher et al.

Summary: Bordetella pertussis, the highly contagious agent of whooping cough, has evolved as a successful human pathogen by acquiring virulence factors and adapting its metabolism to the human respiratory tract. It overcomes host immune defenses through sophisticated mechanisms and interferes with vaccine-induced adaptive immunity. Ongoing evolutionary adaptation has made B. pertussis a highly successful human pathogen.

VIRULENCE (2021)

Review Infectious Diseases

Bacterial RTX toxins and host immunity

Jawid Nazir Ahmad et al.

Summary: RTX toxins play a crucial role in bacterial infections by inhibiting phagocytic cells, dampening inflammatory responses, compromising epithelial barrier, and reducing the phagocytic ability of macrophages, thus promoting bacterial survival and proliferation in the host.

CURRENT OPINION IN INFECTIOUS DISEASES (2021)

Article Immunology

IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils

Lisa Borkner et al.

Summary: Understanding the mechanism of protective immunity in the nasal mucosae is crucial for effective vaccine design against Bordetella pertussis. IL-17 plays a critical role in both natural and acquired immunity to pertussis in the nasal mucosae, mobilizing neutrophils, especially Siglec-F+ neutrophils. Depletion of CD4 T cells delays bacterial clearance, while IL-17-producing CD4(+) T-RM cells aid in rapid clearance of bacteria from the nasal cavity in re-infected mice.

MUCOSAL IMMUNOLOGY (2021)

Article Immunology

Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal Bordetella pertussis Inoculation in Mice

Illiassou Hamidou Soumana et al.

Summary: The study found that inoculating mice with Bordetella pertussis in the nasopharynx can result in robust growth in the upper respiratory tract with little immune response, leading to prolonged and persistent infection.

EMERGING INFECTIOUS DISEASES (2021)

Article Immunology

Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation

Jawid Nazir Ahmad et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Infectious Diseases

Bordetella bronchiseptica: a rare cause of meningitis

Christopher Radcliffe et al.

BMC INFECTIOUS DISEASES (2020)

Article Biochemical Research Methods

mScarlet: a bright monomeric red fluorescent protein for cellular imaging

Daphne S. Bindels et al.

NATURE METHODS (2017)

Article Infectious Diseases

An update of the global burden of pertussis in children younger than 5 years: a modelling study

Karene Hoi Ting Yeung et al.

LANCET INFECTIOUS DISEASES (2017)

Article Multidisciplinary Sciences

A BaSiC tool for background and shading correction of optical microscopy images

Tingying Peng et al.

NATURE COMMUNICATIONS (2017)

Article Microbiology

Bordetella holmesii: Still Emerging and Elusive 20 Years On

Laure F. Pittet et al.

MICROBIOLOGY SPECTRUM (2016)

Article Medicine, General & Internal

Asymptomatic transmission and the resurgence of Bordetella pertussis

Benjamin M. Althouse et al.

BMC MEDICINE (2015)

Review Immunology

Contribution of pertussis toxin to the pathogenesis of pertussis disease

Nicholas H. Carbonetti

PATHOGENS AND DISEASE (2015)

Review Microbiology

Bordetella pertussis pathogenesis: current and future challenges

Jeffrey A. Melvin et al.

NATURE REVIEWS MICROBIOLOGY (2014)

Article Multidisciplinary Sciences

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

Jason M. Warfel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Review Biochemistry & Molecular Biology

The ins and outs of pertussis toxin

Camille Locht et al.

FEBS JOURNAL (2011)

Article Food Science & Technology

Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)

Supachoke Mangmool et al.

TOXINS (2011)

Review Immunology

Programmed cell death of dendritic cells in immune regulation

Min Chen et al.

IMMUNOLOGICAL REVIEWS (2010)

Review Microbiology

RTX proteins: a highly diverse family secreted by a common mechanism

Irena Linhartova et al.

FEMS MICROBIOLOGY REVIEWS (2010)

Article Immunology

Pathology and pathogenesis of fatal Bordetella pertussis infection in infants

Christopher D. Paddock et al.

CLINICAL INFECTIOUS DISEASES (2008)

Review Immunology

Division of labor between dendritic cell subsets of the lung

C. H. Geurtsvan Kessel et al.

MUCOSAL IMMUNOLOGY (2008)

Article Multidisciplinary Sciences

RTX cytotoxins recognize β2 integrin receptors through N-linked oligosaccharides

Jana Morova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Immunology

Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary route

Aurelie Cleret et al.

JOURNAL OF IMMUNOLOGY (2007)

Article Biotechnology & Applied Microbiology

Engineering and characterization of a superfolder green fluorescent protein

JD Pedelacq et al.

NATURE BIOTECHNOLOGY (2006)

Article Medicine, Research & Experimental

Pertussis toxin inhibits neutrophil recruitment to delay anti body-mediated clearance of Bordetella pertussis

GS Kirimanjeswara et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Article Pediatrics

Bordetella bronchiseptica infection in pediatric lung transplant recipients

Z Ner et al.

PEDIATRIC TRANSPLANTATION (2003)

Article Immunology

Phagocytosis of Bordetella pertussis incubated with convalescent serum

PS Mobberley-Schuman et al.

JOURNAL OF INFECTIOUS DISEASES (2003)

Article Immunology

Bordetella pertussis virulence factors affect phagocytosis by human neutrophils

CL Weingart et al.

INFECTION AND IMMUNITY (2000)