4.6 Article

Apoptosis and tissue thinning contribute to symmetric cell division in the developing mouse epidermis in a nonautonomous way

Journal

PLOS BIOLOGY
Volume 20, Issue 8, Pages -

Publisher

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.3001756

Keywords

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Funding

  1. U.S-Israel Binational Science Foundation (BSF) [2019230]
  2. Israel Science Foundation (ISF) [1174/20]
  3. Richard Eimert Research Fund on Solid Tumors of the Faculty of Medicine, Tel Aviv University

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This study identifies a novel regulator, BCAM, that guides self-organization (SO) in the developing epidermis by regulating apoptosis and epidermal architecture.
AMUito:tiPclseapsinecdolenfoirrmietnhtaattaiollnhe(aSdOin)gilsevaeclsoanrsereerpvreedsemnteecdhcoarnriescmtlyt: hat governs cell fate and tissue morphogenesis. In the developing epidermis, a balance between self-renewing symmetric divisions and differentiative asymmetric divisions is necessary for normal development. While the cellular machinery that executes SO is well characterized, the extrinsic cues that guide it are poorly understood. Here, we identified the basal cell adhesion molecule (BCAM), a beta 1 integrin coreceptor, as a novel regulator of epidermal morphogenesis. In utero RNAi-mediated depletion of Bcam in the mouse embryo did not hinder beta 1 integrin distribution or cell adhesion and polarity. However, Bcam depletion promoted apoptosis, thinning of the epidermis, and symmetric cell division, and the defects were reversed by concomitant overexpression of the apoptosis inhibitor Xiap. Moreover, in mosaic epidermis, depletion of Bcam or Xiap induced symmetric divisions in neighboring wild-type cells. These results identify apoptosis and epidermal architecture as extrinsic cues that guide SO in the developing epidermis.

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