Journal
G3-GENES GENOMES GENETICS
Volume 12, Issue 8, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/g3journal/jkac146
Keywords
multiparental populations; MPP; genome-wide association studies; GWAS; quantitative trait loci mapping; QTL mapping
Categories
Funding
- Jackson Laboratory Cube Initiative
- National Institute of Health (NIH) [R01GM070683, F32GM134599, R01DK101573, RC2DK125961]
- University of Wisconsin-Madison, Department of Biochemistry
- Office of the Vice Chancellor for Research and Graduate Education
- Wisconsin Alumni Research Foundation
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The Collaborative Cross and the Diversity Outbred mouse populations are related multiparental populations that are ideal for mapping genetic loci that regulate phenotypes. The QTLViewer software and website provide a graphical exploration of quantitative trait locus mapping and increase accessibility to these genetic resources.
The Collaborative Cross and the Diversity Outbred mouse populations are related multiparental populations, derived from the same 8 isogenic founder strains. They carry >50 M known genetic variants, which makes them ideal tools for mapping genetic loci that regulate phenotypes, including physiological and molecular traits. Mapping quantitative trait loci requires statistical and computational training, which can present a barrier to access for some researchers. The QTLViewer software allows users to graphically explore Collaborative Cross and Diversity Outbred quantitative trait locus mapping and related analyses performed through the R/qtl2 package. Additionally, the QTLViewer website serves as a repository for published Collaborative Cross and Diversity Outbred studies, increasing the accessibility of these genetic resources to the broader scientific community.
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