Journal
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
Volume 16, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2022.868473
Keywords
inbred mice; cognitive challenges; genetic background; AD-related mutations; cognitive profile
Categories
Funding
- Italian Ministry of Health
Ask authors/readers for more resources
Efforts have been made to increase the face validity of AD mouse models by generating AD mutations closer to those identified in humans and enhancing genetic diversity of wild-type backgrounds. However, the cognitive specialization of inbred strains and the importance of studying destabilization of memory circuits in pre-symptomatic mice have been less considered. Studies have shown that inbred mice differ in their innate predisposition to rely on episodic vs. procedural memory and investigating training-driven neural alterations in asymptomatic mutants unveils early synaptic damage.
Increasing efforts have been made in the last decades to increase the face validity of Alzheimer's disease (AD) mouse models. Main advancements have consisted in generating AD mutations closer to those identified in humans, enhancing genetic diversity of wild-type backgrounds, and choosing protocols much apt to reveal AD-like cognitive dysfunctions. Nevertheless, two aspects remain less considered: the cognitive specialization of inbred strains used as recipient backgrounds of mutations and the heuristic importance of studying destabilization of memory circuits in pre-symptomatic mice facing cognitive challenges. This article underscores the relevance of these behavioral/experimental aspects by reviewing data which show that (i) inbred mice differ in their innate predisposition to rely on episodic vs. procedural memory, which implicates differential sensitivity to mutations aimed at disrupting temporal lobe-dependent memory, and that (ii) investigating training-driven neural alterations in asymptomatic mutants unveils early synaptic damage, which considerably anticipates detection of AD first signs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available