Journal
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
Volume 16, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2022.931964
Keywords
animal model; behaviour; depression; mood; stress; rodent; disorder; symptom
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Funding
- Research in the Chaudhury Laboratory from NYUAD Annual Research Budget
- Brain and Behavior Research Foundation [NARSAD: 22715]
- NYUAD Research Enhancement Fund
- NYU Research Enhancement Fund
- Al Jalila Research Foundation [AJF20163]
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Animal studies have significantly improved our understanding of the pathogenesis of depressive and mood disorders. Rodent behavioural models, in particular, have proven to be highly informative. This article provides a comprehensive overview of the most popular behavioural models, including their physiological, circuit, and molecular biological correlates. It also evaluates the outcomes, strengths, weaknesses, and translational value of behavioural stress paradigms and tests, with a focus on pharmacological studies.
Animal studies over the past two decades have led to extensive advances in our understanding of pathogenesis of depressive and mood disorders. Among these, rodent behavioural models proved to be of highest informative value. Here, we present a comprehensive overview of the most popular behavioural models with respect to physiological, circuit, and molecular biological correlates. Behavioural stress paradigms and behavioural tests are assessed in terms of outcomes, strengths, weaknesses, and translational value, especially in the domain of pharmacological studies.
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