☆ 4.6 Review

Mechanisms of Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases

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BIOMETALS (2019)

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Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Yanhua Mou et al.

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A ferroptosis-based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis

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SCIENTIFIC REPORTS (2019)

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Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer's disease

Hamidreza Komaki et al.

BRAIN RESEARCH BULLETIN (2019)

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Cell death: a review of the major forms of apoptosis, necrosis and autophagy

Mark S. D'Arcy

CELL BIOLOGY INTERNATIONAL (2019)

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Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology

Ibrahima Diouf et al.

NEUROBIOLOGY OF DISEASE (2019)

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NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis

Liyan Hou et al.

TOXICOLOGY (2019)

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Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling

Wenbin Wan et al.

FRONTIERS IN NEUROLOGY (2019)

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Powerful system for cell protection revealed

Brent R. Stockwell

NATURE (2019)

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FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

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Prionoid Proteins in the Pathogenesis of Neurodegenerative Diseases

Cameron Wells et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

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Lipid storage and lipophagy regulates ferroptosis

Yuansong Bai et al.

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Treating Alzheimer's disease by targeting iron

Sara Nikseresht et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

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Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease

Taro Saito et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis

Che-Lin Hu et al.

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The Emerging Roles of Ferroptosis in Huntington's Disease

Yajing Mi et al.

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Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

Sofie Voet et al.

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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

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Parkinson's Disease and Parkinsonism

Michael T. Hayes

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Alzheimer's disease

C. A. Lane et al.

EUROPEAN JOURNAL OF NEUROLOGY (2018)

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Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study

Scott Ayton et al.

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Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis?

Caroline Moreau et al.

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Nrf2-Keap1 signaling in oxidative and reductive stress

Ilaria Bellezza et al.

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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

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Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologically

Sonal Agrawal et al.

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Alterations in System x(c) (-) Expression in the Retina of Type 1 Diabetic Rats and the Role of Nrf2

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High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein

Fengju Jia et al.

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α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

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Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

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Mitochondria and Iron: current questions

Bibbin T. Paul et al.

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The elemental role of iron in DNA synthesis and repair

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Iron accumulation and microglia activation contribute to substantia nigra hyperechogenicity in the 6-OHDA-induced rat model of Parkinson's disease

Yaqin Zhu et al.

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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

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The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility

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Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

William Sealy Hambright et al.

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Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson's disease

Antonio Martin-Bastida et al.

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PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

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CELL (2017)

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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

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CELL (2017)

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Huntington's Disease-Update on Treatments

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Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease

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AMERICAN JOURNAL OF NEURORADIOLOGY (2016)

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Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

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Iron and dopamine: a toxic couple

Dominic J. Hare et al.

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Ferroptosis: process and function

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CELL DEATH AND DIFFERENTIATION (2016)

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Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

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An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

Matthew Jennis et al.

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Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

Bruce Do Van et al.

NEUROBIOLOGY OF DISEASE (2016)

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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Ferrootosis: Death by Lipid Peroxidation

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TRENDS IN CELL BIOLOGY (2016)

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Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment

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Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons

Changyi Ji et al.

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Glutaminolysis and Transferrin Regulate Ferroptosis

Minghui Gao et al.

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Ferroptosis as a p53-mediated activity during tumour suppression

Le Jiang et al.

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Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease

Michael M. Zeineh et al.

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Iron-Induced Damage in Cardiomyopathy: Oxidative-Dependent and Independent Mechanisms

Elena Gammella et al.

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Longitudinal midbrain changes in early Parkinson's disease: Iron content estimated from R2*/MRI

Marguerite Wieler et al.

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Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Scott Ayton et al.

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Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

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Autosis and autophagic cell death: the dark side of autophagy

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Cerebellar Hypoplasia in Mice Lacking Selenoprotein Biosynthesis in Neurons

Eva K. Wirth et al.

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Perturbed Iron Distribution in Alzheimer's Disease Serum, Cerebrospinal Fluid, and Selected Brain Regions: A Systematic Review and Meta-Analysis

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Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Rachid Skouta et al.

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The role of iron and reactive oxygen species in cell death

Scott J. Dixon et al.

NATURE CHEMICAL BIOLOGY (2014)

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PRO-INFLAMMATORY CYTOKINE-MEDIATED FERROPORTIN DOWN-REGULATION CONTRIBUTES TO THE NIGRAL IRON ACCUMULATION IN LIPOPOLYSACCHARIDE-INDUCED PARKINSONIAN MODELS

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Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

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Glutathione peroxidase activity is neuroprotective in models of Huntington's disease

Robert P. Mason et al.

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The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease

Animesh Alexander Raha et al.

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Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients

Aleksandar Ignjatovic et al.

AMYOTROPHIC LATERAL SCLEROSIS (2012)

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Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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CELL (2012)

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Necroptosis: An emerging form of programmed cell death

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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2012)

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The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

Lin W. Hung et al.

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Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

Justin Y. Kwan et al.

PLOS ONE (2012)

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Functional lipidomics of oxidized products from polyunsaturated fatty acids

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CHEMISTRY AND PHYSICS OF LIPIDS (2011)

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Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain

Frederick P. Bellinger et al.

MOLECULAR NEURODEGENERATION (2011)

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Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

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Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

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BLOOD (2009)

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Scara5 Is a Ferritin Receptor Mediating Non-Transferrin Iron Delivery

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DEVELOPMENTAL CELL (2009)

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Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia

Alessandro Campanella et al.

HUMAN MOLECULAR GENETICS (2009)

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Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model

Ulaganathan Mabalirajan et al.

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Combination therapy with Coenzyme Q(10) and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's Diseases

Lichuan Yang et al.

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Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins

Jun Wang et al.

NEUROCHEMISTRY INTERNATIONAL (2009)

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Intracellular iron transport and storage: From molecular mechanisms to health implications

Elizabeth L. Mackenzie et al.

ANTIOXIDANTS & REDOX SIGNALING (2008)

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Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects

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JOURNAL OF NEUROLOGY (2007)

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