Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.930105
Keywords
age-related hearing loss; metabolic syndrome; mitochondrial dysfunction; cochlea; mitochondria
Categories
Funding
- Cultivation Project of the Major Research Plan of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Sailing Program
- Ruijin Youth NSFC Cultivation Fund
- [91949119]
- [82101212]
- [82101209]
- [21ZR1440200]
- [20YF1426400]
- [19YF1430300]
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With the increase in life expectancy worldwide, elderly populations are growing, including in China. Age-related hearing loss and metabolic syndrome are common chronic diseases, and many people suffer from both simultaneously. Recent studies have found that mitochondrial dysfunction is present in both conditions, highlighting the importance of studying the impact of metabolic syndrome on age-related hearing loss from the perspective of mitochondrial dysfunction.
With the increase in life expectancy in the global population, aging societies have emerged in many countries, including China. As a common sensory defect in the elderly population, the prevalence of age-related hearing loss and its influence on society are increasing yearly. Metabolic syndrome is currently one of the main health problems in the world. Many studies have demonstrated that metabolic syndrome and its components are correlated with a variety of age-related diseases of the peripheral sensory system, including age-related hearing loss. Both age-related hearing loss and metabolic syndrome are high-prevalence chronic diseases, and many people suffer from both at the same time. In recent years, more and more studies have found that mitochondrial dysfunction occurs in both metabolic syndrome and age-related hearing loss. Therefore, to better understand the impact of metabolic syndrome on age-related hearing loss from the perspective of mitochondrial dysfunction, we reviewed the literature related to the relationship between age-related hearing loss and metabolic syndrome and their components to discern the possible role of mitochondria in both conditions.
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