Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.888989
Keywords
Alzheimer's disease; microglia; iron metabolism; A beta; immune inflammation
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Funding
- Changsha Central Hospital Affiliated to University of South China Foundation of key Program [YNKY201901]
- Hunan Province Foundation of High-level Health Talent (225 Program), Science and Technology Key Program of Hunan Provincial Health Committee [20201904]
- Natural Science Foundation of Hunan Province [2021JJ30753]
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This study discusses the role of microglia in Alzheimer's disease (AD), including immune-inflammatory pathology and iron metabolism disorders. The research is important for understanding the role of microglia in iron metabolism in AD and discovering new potential therapeutic targets for the disease.
Alzheimer's disease (AD), the most common type of senile dementia, includes the complex pathogenesis of abnormal deposition of amyloid beta-protein (A beta), phosphorylated tau (p-tau) and neuroimmune inflammatory. The neurodegenerative process of AD triggers microglial activation, and the overactivation of microglia produces a large number of neuroimmune inflammatory factors. Microglia dysfunction can lead to disturbances in iron metabolism and enhance iron-induced neuronal degeneration in AD, while elevated iron levels in brain areas affect microglia phenotype and function. In this manuscript, we firstly discuss the role of microglia in AD and then introduce the role of microglia in the immune-inflammatory pathology of AD. Their role in AD iron homeostasis is emphasized. Recent studies on microglia and ferroptosis in AD are also reviewed. It will help readers better understand the role of microglia in iron metabolism in AD, and provides a basis for better regulation of iron metabolism disorders in AD and the discovery of new potential therapeutic targets for AD.
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