Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.903269
Keywords
autosomal dominant Alzheimer's disease; neural network; functional MRI (fMRI); presenilin; amyloid precursor protein (APP)
Categories
Funding
- Key Project of the National Natural Science Foundation of China [81530036]
- National Key Scientific Instrument and Equipment Development Project [31627803]
- Mission Program of Beijing Municipal Administration of Hospitals [SML20150801]
- Beijing Scholars Program
- Beijing Brain Initiative from Beijing Municipal Science and Technology Commission [Z161100000216137]
- Innovation Base Training and Development Special Program [Z171100002217007]
- CHINA-CANADA Joint Initiative on Alzheimer's Disease and Related Disorders [81261120571]
- Project for Outstanding Doctor with Combined Ability of Western and Chinese Medicine
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Alzheimer's disease is the most common form of dementia with no cure. Research on early biomarkers and functional connectivity changes in the brain is crucial for early detection and intervention.
Alzheimer's disease (AD) is the most common form of dementia, with no cure to stop its progression. Early detection, diagnosis, and intervention have become the hot spots in AD research. The long asymptomatic and slightly symptomatic phases of autosomal dominant AD (ADAD) allow studies to explore early biomarkers and the underlying pathophysiological changes. Functional magnetic resonance imaging (fMRI) provides a method to detect abnormal patterns of brain activity and functional connectivity in vivo, which correlates with cognitive decline earlier than structural changes and more strongly than amyloid deposition. Here, we will provide a brief overview of the network-level findings in ADAD in fMRI studies. In general, abnormalities in brain activity were mainly found in the hippocampus, the medial temporal lobe (MTL), the posterior cortex, the cingulate cortices, and the frontal regions in ADAD. Moreover, ADAD and sporadic AD (SAD) have similar fMRI changes, but not with aging.
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