Journal
CELL REPORTS
Volume 39, Issue 10, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2022.110932
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Funding
- BBSRC
- Ser Cymru Fellowship [80762-CU-080]
- Wellcome Trust ISSF Seedcorn Award [105613/Z/14/Z]
- MINECO [PDI 2019-109285GA-I00]
- Wellcome Trust [105613/Z/14/Z] Funding Source: Wellcome Trust
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This study uses in vivo two-photon functional imaging to investigate the role of A24b/M2-V1(axons) in visual selective attention in mice. The results suggest that the activity of these axons is associated with licking behavior, modulated by reward, and biased toward the sensory cortical hemisphere representing the currently discriminated stimulus.
A long-range circuit linking the medial frontal cortex to the primary visual cortex (V1) has been proposed to mediate visual selective attention in mice during visually guided behavior Here, we use in vivo two-photon functional imaging to measure the endogenous activity of axons of A24b/M2 neurons from this region projecting to layer 1 of V1 (A24b/M2-V1(axons)) in mice either passively viewing stimuli or performing a go/no-go visually guided task. We observe that while A24b/M2-V1(axons) are recruited under these conditions, this is not linked to enhancement of neural or behavioral measures of sensory coding. Instead, A24b/M2-V1(axon) activity is associated with licking behavior, modulated by reward, and biased toward the sensory cortical hemisphere representing the stimulus currently being discriminated.
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