4.7 Article

Hepatitis, testicular degeneration, and ataxia in DIDO3-deficient mice with altered mRNA processing

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Gene architecture directs splicing outcome in separate nuclear spatial regions

Luna Tammer et al.

Summary: This study reveals that the peripheral and central regions of the nucleus harbor genes with different exon-intron architectures and that they lead to different splicing outcomes. Genes in the periphery have low GC content exons and undergo exon definition splicing, while genes in the nuclear center have high GC content exons and undergo intron definition splicing. This highlights the importance of 3D genome organization in splicing regulation.

MOLECULAR CELL (2022)

Article Biochemistry & Molecular Biology

Interplay between splicing and transcriptional pausing exerts genome-wide control over alternative polyadenylation

Carmen Mora Gallardo et al.

Summary: Recent studies have found multiple polyadenylation sites in nearly all mammalian genes, indicating potential for alternative polyadenylation mechanisms. External factors such as splicing may interact to regulate this process. Research on mutants in the DIDO gene shows potential control of 3' end processing by a window of opportunity.

TRANSCRIPTION-AUSTIN (2021)

Review Cell Biology

Splicing regulation in brain and testis: common themes for highly specialized organs

Chiara Naro et al.

Summary: Alternative splicing plays a significant role in increasing the structural complexity of metazoans, particularly in organs like the brain and testes which express a large repertoire of splice variants. The regulation of alternative splicing has a profound impact on the functionality and differentiation of brain and testicular cells, contributing to their high transcriptome complexity.

CELL CYCLE (2021)

Article Cell Biology

Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels

Agnes Futterer et al.

Summary: The truncation of the DIDO gene affects RNA splicing and transcription termination in ESC and MEF, altering gene expression involved in differentiation and reprogramming. DIDO3 interacts with the helicase DHX9, leading to increased nuclear R-loop content and DNA replication stress. These defects result in failure of ESC differentiation and MEF reprogramming.

CELL DEATH & DISEASE (2021)

Article Biochemistry & Molecular Biology

Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing

Wei Jiang et al.

Summary: Alternative splicing is a key mechanism contributing to protein diversity in higher eukaryotes, playing a crucial role in regulating gene expression. Many human diseases and cancers are associated with alternative splicing, highlighting the importance of understanding its mechanisms and regulation for disease research.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

Article Biotechnology & Applied Microbiology

Dynamic Alternative Splicing During Mouse Preimplantation Embryo Development

Yongqiang Xing et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Review Biochemistry & Molecular Biology

The Function of Pre-mRNA Alternative Splicing in Mammal Spermatogenesis

Huibin Song et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Article Biochemistry & Molecular Biology

Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing

Carmen Mora Gallardo et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Neurosciences

Neuron-specific alternative splicing of transcriptional machineries: Implications for neurodevelopmental disorders

Robert S. Porter et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2018)

Review Cell Biology

Hepatocyte polyploidization and its association with pathophysiological processes

Min-Jun Wang et al.

CELL DEATH & DISEASE (2017)

Article Endocrinology & Metabolism

Alternative RNA Splicing in the Pathogenesis of Liver Disease

Nicholas J. G. Webster

FRONTIERS IN ENDOCRINOLOGY (2017)

Review Genetics & Heredity

RNA mis-splicing in disease

Marina M. Scotti et al.

NATURE REVIEWS GENETICS (2016)

Article Multidisciplinary Sciences

Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans

Hao Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Developmental Biology

The human testis-specific proteome defined by transcriptomics and antibody-based profiling

D. Djureinovic et al.

MOLECULAR HUMAN REPRODUCTION (2014)

Article Biochemical Research Methods

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

Helga Thorvaldsdottir et al.

BRIEFINGS IN BIOINFORMATICS (2013)

Article Biochemistry & Molecular Biology

The splicing landscape is globally reprogrammed during male meiosis

Ralf Schmid et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Multidisciplinary Sciences

Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice

Kosuke Oana et al.

SCIENTIFIC REPORTS (2013)

Article Biochemistry & Molecular Biology

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Alfredo Castello et al.

Article Biochemistry & Molecular Biology

Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development

A. Fuetterer et al.

CELL DEATH AND DIFFERENTIATION (2012)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Article Biotechnology & Applied Microbiology

Alternative splicing is frequent during early embryonic development in mouse

Timothee Revil et al.

BMC GENOMICS (2010)

Review Neurosciences

Aberrant RNA processing events in neurological disorders

Karen Anthony et al.

BRAIN RESEARCH (2010)

Review Cell Biology

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

Charles J. David et al.

GENES & DEVELOPMENT (2010)

Editorial Material Gastroenterology & Hepatology

Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences

Carmen Berasain et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

Article Cell Biology

Tissue-specific mechanisms of alternative polyadenylation: testis, brain, and beyond

Clinton C. MacDonald et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2010)

Review Biochemistry & Molecular Biology

RNA and Disease

Thomas A. Cooper et al.

Review Biochemistry & Molecular Biology

The Spliceosome: Design Principles of a Dynamic RNP Machine

Markus C. Wahl et al.

Article Multidisciplinary Sciences

Pentamidine reverses the splicing defects associated with myotonic dystrophy

M. Bryan Warf et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

A high-throughout screening strategy identifies cardiotonic steroids as alternative splicing modulators

Peter Stoilov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability

Varvara Trachana et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Medicine, Research & Experimental

Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms

A Fütterer et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Article Biotechnology & Applied Microbiology

Variation in alternative splicing across human tissues

G Yeo et al.

GENOME BIOLOGY (2004)

Review Cell Biology

Pre-mRNA splicing and human disease

NA Faustino et al.

GENES & DEVELOPMENT (2003)

Article Biochemistry & Molecular Biology

The spliceosome: the most complex macromolecular machine in the cell?

TW Nilsen

BIOESSAYS (2003)

Article Biochemistry & Molecular Biology

Large-scale proteomic analysis of the human splicesome

J Rappsilber et al.

GENOME RESEARCH (2002)