Journal
ADVANCED HEALTHCARE MATERIALS
Volume 11, Issue 19, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202200872
Keywords
amyloid; biomineralization; enamel epitaxial growth; pit and fissure sealing; prevention of dental caries
Funding
- National Natural Science Foundation of China [82071075, 21875132]
- National Key R&D Program of China [2020YFA0710400, 2020YFA0710402]
- 111 Project [B14041]
- Fundamental Research Funds for the Central Universities [GK201801003, 2020TS090]
- Innovation Capability Support Program of Shaanxi [2020TD-024, 2020TD-041, 2022TD-35]
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This study proposes a new strategy for sealing pits and fissures using amyloid-mediated biomimetic remineralization, which can effectively prevent caries. It is shown that delivering a nanofilm into the deepest zone of the fossae and inducing the formation of remineralized enamel inside can achieve a structure and mechanical stability similar to natural enamel, along with good biocompatibility and antibacterial properties.
The pits and fissures of teeth have high caries susceptibility, and sealing these areas is considered as an effective method to prevent caries. However, long-term caries prophylaxis cannot be maintained because of the negative effects derived from the technical sensitivity and disadvantages of sealing materials. Herein, a new strategy is proposed to occlude fossae by amyloid-mediated biomimetic remineralization. In contrast to conventional inward blocking from the outside of fossae, amyloid-mediated biomimetic mineralization delivers an amyloid-like protein nanofilm into the deepest zone of the fossae and induces the formation of remineralized enamel inside. Such assembly from lysozyme conjugated with poly (ethylene glycol) enriches the interface with strongly bonded ionsand directs in situ nucleation to achieve enamel epitaxial growth. Not only is the structure of the enamel-like crystalline hydroxyapatite layer but also its mechanical stability is similar to that of natural enamel. Furthermore, the layer shows good biocompatibility and antibacterial properties. On the basis of the findings, it is demonstrated that amyloid-like protein aggregation may provide an enamel remineralization strategy to modify the current clinically available methods of pit and fissure sealing and shows great promise in preventing caries.
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