Journal
ADVANCED HEALTHCARE MATERIALS
Volume 11, Issue 19, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202200960
Keywords
breast tumors; estrogen receptor alpha; photothermal therapy; polydopamine; targeted protein degradation
Funding
- National Natural Science Foundation of China [22073070]
- Science and Technology Research Project of Education Department of Hubei Province [Q20201610]
- Hubei Polytechnic University Start-up Foundation for Advanced Talent [21XJZ03R]
- Scientific and technological innovation team support program project for excellent young people of Hubei Polytechnic University [13xtz08]
- Open Fund of Hubei Key Laboratory of Mine Environmental Pollution Control Remediation [2020104]
- Science and Technology Plans of Tianjin [21ZYJDJC00050]
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This study reports a method using polydopamine nanoparticles for targeted therapy of breast tumors, which can efficiently ablate tumors under low irradiation density without causing significant inflammation.
The major challenges of photothermal therapy (PTT) toward clinical application are the severe skin injury and inflammation response associated with high power laser irradiation. Herein, polydopamine nanoparticles (PDA-EST and PDA-RAL) targeted to estrogen receptor alpha (ER alpha) for efficient ablation of breast tumor under a low irradiation density of 0.1 W cm(-2) are reported. These nanoparticles are capable of recruiting ER alpha on their surface and induce a complete ER alpha degradation via localized heat. Owing to the ER alpha targetability, PDA-EST and PDA-RAL strongly suppress the proliferation of breast cancer cells without causing significant inflammation. This work provides a generalized method for enhancing PTT efficacy under low irradiation density.
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