4.7 Article

Breathable and Stretchable Dressings for Accelerating Healing of Infected Wounds

Related references

Note: Only part of the references are listed.
Review Chemistry, Multidisciplinary

Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations

Qiankun Zeng et al.

Summary: This article reviews the importance of wound dressings based on nanomaterials in wound treatment and highlights their functional advantages and smart development trends. It also explores the challenges and opportunities associated with nanomaterial-based wound dressings in clinical practice.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Facile Synthesis of Zn2+-Based Hybrid Nanoparticles as a New Paradigm for the Treatment of Internal Bacterial Infections

Yue Huang et al.

Summary: Transition metal ions have been used as sterilizing agents for thousands of years, but traditional metal or metal oxide nanoparticles cannot be directly medicated into the human body due to potential toxicity. Novel Zn2+-epsilon-poly(l-lysine)-protocatechuic aldehyde-based hybrid nanoparticles with on-demand release capability were synthesized for the first time in this study. These nanoparticles effectively adhere to bacterial cells, release Zn2+ in situ, exhibit excellent bactericidal ability, and show negligible toxicity, making them ideal candidates for treating internal infections.

ADVANCED FUNCTIONAL MATERIALS (2022)

Article Chemistry, Multidisciplinary

Nanozyme-Based Stretchable Hydrogel of Low Hysteresis with Antibacterial and Antioxidant Dual Functions for Closely Fitting and Wound Healing in Movable Parts

Yanyan Li et al.

Summary: The newly designed MP composite hydrogel exhibits excellent mechanical properties and adhesiveness, providing a close fit for movable parts and effectively preventing bacterial infection, ultimately promoting wound healing.

ADVANCED FUNCTIONAL MATERIALS (2022)

Article Chemistry, Multidisciplinary

Peptide Polymer-Doped Cement Acting as an Effective Treatment of MRSA-Infected Chronic Osteomyelitis

Yueming Wu et al.

Summary: The PMMA@polymer, designed as a synthetic mimic of host defense peptide, shows potent activity against MRSA, superior therapeutic efficacy in vivo, and low toxicity, suggesting great potential as an effective treatment for MRSA-infected chronic osteomyelitis.

ADVANCED FUNCTIONAL MATERIALS (2022)

Article Chemistry, Multidisciplinary

Highly Efficient Self-Healing Multifunctional Dressing with Antibacterial Activity for Sutureless Wound Closure and Infected Wound Monitoring

Ning Tang et al.

Summary: The study introduces a novel self-healing, antibacterial, and multifunctional wound dressing for sutureless wound closure and real-time monitoring. The dressing features high mechanical toughness, biocompatibility, and outstanding antibacterial activity, effectively inhibiting bacterial growth and accelerating healing. In vivo tests demonstrate that the dressing can help in wound closure and deposition of collagen, while the integrated sensor array provides real-time monitoring of temperature, pH, and glucose levels in the wound area. Ultimately, this multifunctional dressing would be valuable for personalized monitoring and treatment approaches in wound healing management.

ADVANCED MATERIALS (2022)

Article Engineering, Environmental

Hollow nanosphere-doped bacterial cellulose and polypropylene wound dressings: Biomimetic nanocatalyst mediated antibacterial therapy

Shumin Zhang et al.

Summary: Reactive oxygen species (ROS) have been demonstrated to be effective against bacterial infections. Inspired by the biocatalytic ability of nanozymes in regulating ROS levels, a hollow mesoporous nanocatalyst with multienzyme-mimicking activity was developed. The nanocatalyst can catalyze glucose into highly reactive hydrogen radicals, resulting in remarkable antibacterial ability. A novel antibacterial wound dressing was fabricated by assembling the nanocatalyst on bacterial cellulose enveloped polypropylene composites, which showed outstanding moisture retention ability and breathability, as well as remarkable biocompatibility and bacteria inactivation ability. In vivo studies demonstrated that the wound dressing can effectively promote wound healing caused by bacterial infections.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Engineering, Biomedical

Gold Nanoclusters as Nanoantibiotic Auranofin Analogues

William Ndugire et al.

Summary: This study reports the design and synthesis of gold nanoclusters based on the structural motif of auranofin, which exhibit activity against both Gram-negative and Gram-positive bacteria, including multidrug-resistant pathogens. These AuNCs show enhanced antibacterial activity characterized by a greater uptake of gold, increased oxidative stress, moderate inhibition of thioredoxin reductase, and DNA damage. The uptake of AuNCs is not affected by the bacterial outer membrane barrier or extracellular protein binding, unlike Au-I complexes such as auranofin.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Engineering, Biomedical

A Smart Hydrogel with Anti-Biofilm and Anti-Virulence Activities to Treat Pseudomonas aeruginosa Infections

Jingjing Hu et al.

Summary: A smart hydrogel, formed by acid-labile imine linkage, is able to release drugs to inhibit biofilm formation and kill bacteria. The gel shows great potential in inhibiting biofilm formation on medical devices, reducing bacteria pathogenicity, and treating implantation-associated and chronic wound infections.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Chemistry, Multidisciplinary

Fluorescent and Antibacterial Aminobenzeneboronic Acid (ABA)-Modified Gold Nanoclusters for Self-Monitoring Residual Dosage and Smart Wound Care

Le Wang et al.

Summary: The smart dressing can self-monitor the amount of residual nanomedicine in order to evaluate the appropriate time points for the replacement of wound dressings, thus preventing secondary damage to wounds. This novel dressing holds great promise for broad clinical applications.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing

Zifeng Yang et al.

Summary: By grafting cationic polyelectrolyte brushes onto polydopamine/polyacrylamide hydrogels, the mechanical and antibacterial properties of the hydrogels were enhanced, leading to stable coverage, long-lasting antibacterial effects, and fast wound healing.

ADVANCED SCIENCE (2021)

Article Nanoscience & Nanotechnology

Protein-Based Hybrid Responsive Microparticles for Wound Healing

Hui Zhang et al.

Summary: The development of controllable responsive microparticles composed of natural polymer materials, loaded with growth factors and antibacterial peptides, shows promising potential for drug release and wound healing applications. Under near-infrared (NIR) irradiation, these microparticles can achieve desired controllable release of growth factors to promote neovascularization formation. Additionally, the antibacterial peptides embedded in the microparticles provide antibacterial ability during storage and usage. These characteristics make the microparticles ideal for drug delivery and wound healing.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Engineering, Biomedical

Multifunctional Dressing for Wound Diagnosis and Rehabilitation

Ning Tang et al.

Summary: Smart wound dressings integrated with multifunctional materials, wearable sensors, and drug delivery systems can monitor wounds and provide timely diagnosis and treatment, but there are still challenges to be addressed in their development and application.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Engineering, Biomedical

In Situ Synthesized Selenium Nanoparticles-Decorated Bacterial Cellulose/Gelatin Hydrogel with Enhanced Antibacterial, Antioxidant, and Anti-Inflammatory Capabilities for Facilitating Skin Wound Healing

Lin Mao et al.

Summary: The multifunctional nanocomposite hydrogels based on bacterial cellulose, gelatin, and selenium nanoparticles showed excellent antibacterial, antioxidant, and anti-inflammatory capabilities, as well as promising wound healing performance in a rat full-thickness defect model. The hydrogels demonstrated superior mechanical properties, good swelling ability, flexibility, biodegradability, and biocompatibility, making them a great potential wound dressing for preventing infection and accelerating skin regeneration in clinic.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Materials Science, Biomaterials

Evaluation of the in vivo behavior of antibacterial gold nanoparticles for potential biomedical applications

Le Wang et al.

Summary: Pharmacokinetics plays a critical role in the clinical applicability of nanomaterials. By studying the pharmacokinetics of A/M-Au NPs, it was found that they exhibit appropriate pharmacokinetic profile and high biosafety, paving the way for their potential biomedical applications.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Chemistry, Multidisciplinary

Nanogel Encapsulated Hydrogels As Advanced Wound Dressings for the Controlled Delivery of Antibiotics

Yanmiao Fan et al.

Summary: Biocompatible and degradable dual-delivery gel systems based on HBDLDs were constructed via thiol-ene click chemistry, allowing tunable elasticity of the gels and co-delivery of NB and CIP. The innovative hybrid hydrogels showed promise in treating bacterial infections and as wound dressing materials with enhanced cell proliferation and biodegradability.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Nanoscience & Nanotechnology

Organic Polymer Nanoparticles with Primary Ammonium Salt as Potent Antibacterial Nanomaterials

Lixia Guo et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Multidisciplinary Sciences

Bioinspired structural color patch with anisotropic surface adhesion

Yu Wang et al.

SCIENCE ADVANCES (2020)

Article Chemistry, Multidisciplinary

Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol-Modified Gold Nanoparticles by Reducing their Sizes

Yangzhouyun Xie et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Tuning the InVivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles

Chuanqi Peng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Engineering, Biomedical

Multifunctional Smart Skin Adhesive Patches for Advanced Health Care

Insol Hwang et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Article Nanoscience & Nanotechnology

Bacterial Cellulose as a Supersoft Neural Interfacing Substrate

Junchuan Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Review Multidisciplinary Sciences

Antibacterial drug discovery in the resistance era

Eric D. Brown et al.

NATURE (2016)

Article Medicine, Research & Experimental

Immunomodulatory activity of pidotimod administered with standard antibiotic therapy in children hospitalized for community-acquired pneumonia

Susanna Esposito et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

Article Biochemistry & Molecular Biology

The regulatory peptide pidotimod facilitates M2 macrophage polarization and its function

Shenglan Hu et al.

AMINO ACIDS (2014)

Article Chemistry, Multidisciplinary

Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

Jennifer Fishovitz et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Pediatrics

Pidotimod: the past and the present

Gian Vincenzo Zuccotti et al.

ITALIAN JOURNAL OF PEDIATRICS (2013)

Article Toxicology

BC nanofibres: In vitro study of genotoxicity and cell proliferation

Susana Moreira et al.

TOXICOLOGY LETTERS (2009)

Article Chemistry, Multidisciplinary

Mechanisms of antibiotic resistance:: QM/MM modeling of the acylation reaction of a class A β-lactamase with benzylpenicillin

JC Hermann et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Review Biochemistry & Molecular Biology

Antibacterial resistance worldwide: causes, challenges and responses

SB Levy et al.

NATURE MEDICINE (2004)