Breathable and Stretchable Dressings for Accelerating Healing of Infected Wounds

Multidrug-resistant (MDR) bacteria-infected wounds are challenging issues that threaten human health. Herein, L-thioproline (T) and Boc-capped L-thioproline (BT)-decorated gold nanoparticles (TBT-GNPs) with potent antibacterial activity against MDR bacteria are reported. The TBT-GNPs are composited with bacterial cellulose to form wound dressings which show excellent antimicrobial performance both in vitro and in vivo. Moreover, this dressing is both breathable and stretchable which is favorable for gas exchange to accelerate the wound healing. This work is insightful for developing multifunctional dressings to satisfy the clinical requirements.

Automated summary

In this study, L-thioproline and Boc-capped L-thioproline-decorated gold nanoparticles were used to develop wound dressings with potent antibacterial activity against multidrug-resistant bacteria. The dressings, composed of TBT-GNPs and bacterial cellulose, demonstrated excellent antimicrobial performance both in vitro and in vivo. Additionally, the dressings were breathable and stretchable, facilitating gas exchange and accelerating wound healing.