Journal
ADVANCED HEALTHCARE MATERIALS
Volume 11, Issue 18, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202200722
Keywords
bioactive biomaterials; citrate polymers; hybrid biomaterials; multifunctional hydrogels; wound repair
Funding
- National Natural Science Foundation of China [52172288]
- Special Support Program for High Level Talents of Shaanxi Province of China [TZ0278]
- key R&D plan of Shaanxi Province of China [2021GXLH-Z-052]
- State Key Laboratory for Manufacturing Systems Engineering of China [sklms2021006]
- Young Talent Support Plan of Xi'an Jiaotong University of China [QY6J003]
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This study reports a bioactive hydrogel derived from multiple metal coordination that exhibits anti-inflammatory, proangiogenic, and hemostatic properties for wound repair. The hydrogel demonstrates good physical properties and biocompatibility, and effectively promotes wound healing in animal models. This research suggests that multiple metal-organic coordination is an effective strategy for constructing multifunctional bioactive hydrogels.
Bioactive hydrogels with multifunctional properties have shown promising potential in promoting wound repair and skin tissue regeneration. The regulation on different stages of skin wound healing (hemostasis and inflammation) is important for wound repair. Herein, a multiple coordination-derived bioactive hydrogel (SGPA) with anti-inflammatory proangiogenic hemostatic capacity for wound repair is reported. The SGPA is prepared through a facile multiple metal coordination action based on the sodium alginate, metal ions (Gd3+), and bisphosphate functionalized polycitrate. The SGPA exhibits a large porous structure, good injectability, and self-healing performance, as well as controlled biodegradation. Furthermore, the SGPA has good cytocompatibility and hemocompatibility, and can further promote the migration of endothelial cells. The SGPA hydrogel presents good hemostasis capacity in a liver hemorrhage model in vivo. The full-thickness cutaneous wound model demonstrates that the SGPA hydrogel can effectively accelerate the wound repair through down-regulating the inflammatory factors and stimulating the angiogenesis around the wound beds. This work suggests that the multiple metal-organic coordination may be a good strategy to construct the multifunctional bioactive hydrogel for wound repair.
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