Journal
ACS MACRO LETTERS
Volume 11, Issue 7, Pages 889-894Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.2c00298
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Funding
- European Research Council (ERC) [866056]
- Horizon 2020 research and innovation programme [191037]
- French Ministry of Research
- China Scholarship Council (CSC)
- Royal Society for an Industry Fellowship [191037]
- Cytiva
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Degradable polyampholytes with ester-containing cryoprotective properties were synthesized using radical ring-opening (ter)polymerization. These polyampholytes showed enhanced post-thaw recovery when supplemented into DMSO, suggesting their potential application in biotechnology and biomedicine.
ABSTRACT: Macromolecular cryoprotectants based on polyampholytes are showing promise as supplemental cryoprotectants alongside conventional DMSO-based freezing. Here we exploit radical ring-opening (ter)polymerization to access ester-containing cryoprotective polyampholytes, which were shown to be degradable. Using a challenging cell monolayer cryopreservation model, the degradable polyampholytes were found to enhance post-thaw recovery when supplemented into DMSO. This demonstrates that degradable macromolecular cryoprotectants can be developed for application in biotechnology and biomedicine.
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