Journal
THORACIC CANCER
Volume 13, Issue 16, Pages 2355-2361Publisher
WILEY
DOI: 10.1111/1759-7714.14570
Keywords
diagnosis; homocysteine; malignant pleural effusion
Categories
Funding
- National Natural Science Foundation of China [81860501]
- Key Project of the Inner Mongolia Medical University [YKD2021ZD003]
- Research and Development Program of Gusu School of Nanjing Medical University [GSKY20210242]
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This study assessed the accuracy of pleural fluid homocysteine in discriminating between MPE and BPE, and found that its diagnostic accuracy was low.
Objective To assess the accuracy of pleural fluid homocysteine for discriminating malignant pleural effusion (MPE) and benign pleural effusion (BPE). Methods A total of 194 patients from two cohorts (Hohhot and Changshu) with undiagnosed pleural effusion were prospectively enrolled. Their pleural homocysteine was measured, and its diagnostic accuracy and net benefit for MPE were analyzed by receiver operating characteristic (ROC) curve analysis and decision curve analysis, respectively. Results In the Hohhot cohort (n = 136) and the Changshu cohort (n = 58), MPE patients had significantly higher homocysteine levels than BPE patients. The areas under the ROC curves of homocysteine for the diagnosis of MPE were 0.61 (p = 0.027) and 0.59 (p = 0.247), respectively. The decision curves of homocysteine were close to the reference line in both the Hohhot cohort and the Changshu cohort. Conclusion The diagnostic accuracy of pleural fluid homocysteine for MPE was low.
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