4.7 Article

Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

Antibodies to watch in 2021

Helene Kaplon et al.

Summary: The year 2020 saw significant developments in the field of antibody therapeutics, particularly in response to the COVID-19 pandemic. Several antibody products were granted emergency use authorization, and new antibody treatments received first approvals in the US or EU.
Article Biochemistry & Molecular Biology

Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding

Chiara Orlandi et al.

STRUCTURE (2020)

Article Biology

Antibodies exhibit multiple paratope states influencing VH-VL domain orientations

Monica L. Fernandez-Quintero et al.

COMMUNICATIONS BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments

Monica L. Fernandez-Quintero et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Article Medicine, Research & Experimental

Antigen binding allosterically promotes Fc receptor recognition

Jun Zhao et al.

Article Biochemical Research Methods

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

Jing Huang et al.

NATURE METHODS (2017)

Article Biochemical Research Methods

OpenMM 7: Rapid development of high performance algorithms for molecular dynamics

Peter Eastman et al.

PLOS COMPUTATIONAL BIOLOGY (2017)

Review Biophysics

Protein crystallization: Eluding the bottleneck of X-ray crystallography

Joshua Holcomb et al.

AIMS BIOPHYSICS (2017)

Article Biochemical Research Methods

Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces

Cristiano De Michele et al.

PLOS COMPUTATIONAL BIOLOGY (2016)

Review Microbiology

Ig Constant Region Effects on Variable Region Structure and Function

Alena Janda et al.

FRONTIERS IN MICROBIOLOGY (2016)

Article Biophysics

MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories

Robert T. McGibbon et al.

BIOPHYSICAL JOURNAL (2015)

Article Biochemistry & Molecular Biology

The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands

Lucy E. Rayner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Multidisciplinary Sciences

3D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography

Xing Zhang et al.

SCIENTIFIC REPORTS (2015)

Article Medicine, Research & Experimental

Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

Ekaterine Kortkhonjia et al.

Article Biochemistry & Molecular Biology

ABangle: characterising the VHVL orientation in antibodies

J. Dunbar et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2013)

Article Medicine, Research & Experimental

Molecular engineering of antibodies for therapeutic and diagnostic purposes

Frederic Ducancel et al.

Article Allergy

Structure and function of immunoglobulins

Harry W. Schroeder et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

Article Chemistry, Physical

Calculating potentials of mean force from steered molecular dynamics simulations

S Park et al.

JOURNAL OF CHEMICAL PHYSICS (2004)

Article Biochemistry & Molecular Biology

Contrasting IgG structures reveal extreme asymmetry and flexibility

EO Saphire et al.

JOURNAL OF MOLECULAR BIOLOGY (2002)