Saliva as alternative to naso-oropharyngeal swab for SARS-CoV-2 detection by RT-qPCR: a multicenter cross-sectional diagnostic validation study

Article Microbiology

Comparison of Saliva and Midturbinate Swabs for Detection of SARS-CoV-2

Jianyu Lai et al.

Summary: Saliva is a suitable alternative to nasal swabs for detecting SARS-CoV-2, with similar rates of viral detection and higher sensitivity early in the infection. This suggests that saliva may be a superior and cost-effective screening tool for COVID-19.

MICROBIOLOGY SPECTRUM (2022)

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Review Medicine, General & Internal

Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2 A Systematic Review and Meta-analysis

Guillaume Butler-Laporte et al.

Summary: This study evaluated the diagnostic accuracy of saliva NAAT for COVID-19 and found that its accuracy is similar to that of nasopharyngeal swab NAAT, especially in ambulatory settings. This suggests the potential for saliva NAAT as an alternative to nasopharyngeal swabs and supports further research in this area.

JAMA INTERNAL MEDICINE (2021)

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Letter Infectious Diseases

Performance of saliva and mid-turbinate swabs for detection of the beta variant in South Africa

Chun Yat Chu et al.

LANCET INFECTIOUS DISEASES (2021)

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Article Otorhinolaryngology

Variability in instructions for performance of nasopharyngeal swabs across Canada in the era of COVID-19 – what type of swab is actually being performed?

Nole M. Hiebert et al.

Journal of Otolaryngology-Head & Neck Surgery (2021)

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Article Medicine, Research & Experimental

Saliva Direct: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity

Chantal B. F. Vogels et al.

Summary: SalivaDirect simplifies saliva-based diagnostic testing for SARS-CoV-2, demonstrating high positive agreement with traditional swab testing. This innovative approach can make large scale testing more accessible and affordable, offering an alternative solution to supply chain issues.

MED (2021)

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Review Medicine, General & Internal