Higher hair cortisol concentrations associated with shorter leukocyte telomere length in high-risk young adults

Chronic stress is associated with accelerated biological aging as indexed by short age-adjusted leukocyte telomere length (LTL). Exploring links of biological stress responses with LTL has proved challenging due to the lack of biological measures of chronic psychological stress. Hair cortisol concentration (HCC) has emerged as a measure of chronic hypothalamic pituitary adrenal (HPA) axis activation, allowing the examination of relationships between aggregate cortisol concentrations over time and LTL. Our sample includes 92 participants (38% women, M-age = 26 +/- 3.7 years) from a high-risk sample of young adults with previous residential care placements. Two cm hair was collected for HCC, reflecting approximately eight weeks of cortisol secretion. LTL was measured with quantitative polymerase chain reaction (qPCR) in whole blood samples. All samples for LTL were run in triplicate and assayed twice. Linear and polynomial regression models were used to describe the association between HCC and LTL, adjusting for age and sex. HCC and LTL showed negative associations (std. ss = - 0.67, 95% CI [- 0.83, - 0.52], p < .001) in age- and sex-adjusted analyses, indicating that higher HCCs are associated with shorter LTL. Using polynomial regression, we found a curvilinear relationship indicating a stronger negative association at lower cortisol concentrations. Higher HCCs were associated with shorter LTL, supporting the hypothesized involvement of prolonged cortisol secretion in telomere attrition. Thus, HCC may prove useful as a biological indicator of chronic stress associated with aging-related processes in samples exposed to high levels of stress.

Automated summary

Chronic stress has been found to accelerate biological aging, as indicated by shorter age-adjusted leukocyte telomere length. This study explores the association between hair cortisol concentration (HCC), a measure of chronic hypothalamic pituitary adrenal (HPA) axis activation, and leukocyte telomere length (LTL). The results show a negative association between HCC and LTL, suggesting that higher cortisol levels are associated with shorter telomeres. This finding supports the hypothesis that prolonged cortisol secretion is involved in telomere attrition. HCC may serve as a useful biological indicator of chronic stress and aging-related processes in individuals exposed to high levels of stress.