Journal
SCIENTIFIC REPORTS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-16886-w
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Funding
- Spinnaker Health Research Foundation, WA
- McCusker Foundation, WA
- Western Australian State Government
- MRFF
- National Health and Medical Research Council (NHMRC)
- UK MRC
- Imperial College London MRC Doctoral Training Programme
- Department of Jobs, Tourism, Science and Innovation, Government of Western Australian Premier's Fellowship
- ARC Laureate Fellowship
- Stan Perron Centre of Excellence in Childhood Burns
- Perth Children's Hospital Foundation
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The study suggests that non-severe burn trauma in children may leave a sustained immunometabolic imprint, potentially linked to long-term immune changes that may contribute to poor long-term health outcomes observed in children after burn injury.
A growing body of evidence supports the concept of a systemic response to non-severe thermal trauma. This provokes an immunosuppressed state that predisposes paediatric patients to poor recovery and increased risk of secondary morbidity. In this study, to understand the long-term systemic effects of non-severe burns in children, targeted mass spectrometry assays for biogenic amines and tryptophan metabolites were performed on plasma collected from child burn patients at least three years post injury and compared to age and sex matched non-burn (healthy) controls. A panel of 12 metabolites, including urea cycle intermediates, aromatic amino acids and quinolinic acid were present in significantly higher concentrations in children with previous burn injury. Correlation analysis of metabolite levels to previously measured cytokine levels indicated the presence of multiple cytokine-metabolite associations in the burn injury participants that were absent from the healthy controls. These data suggest that there is a sustained immunometabolic imprint of non-severe burn trauma, potentially linked to long-term immune changes that may contribute to the poor long-term health outcomes observed in children after burn injury.
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