Gestational age-specific serum creatinine can predict adverse pregnancy outcomes

Serum creatinine level (SCr) typically decreases during pregnancy due to physiologic glomerular hyperfiltration. Therefore, the clinical practice of estimated glomerular filtration rate (eGFR) based on SCr concentrations might be inapplicable to pregnant women with kidney disease since it does not take into account of the pregnancy-related biological changes. We integrated the Wonju Severance Christian Hospital (WSCH)-based findings and prior knowledge from big data to reveal the relationship between the abnormal but hidden SCr level and adverse pregnancy outcomes. We analyzed 4004 pregnant women who visited in WSCH. Adverse pregnancy outcomes included preterm birth, preeclampsia, fetal growth retardation, and intrauterine fetal demise. We categorized the pregnant women into four groups based on the gestational age (GA)-unadjusted raw distribution (Q1-4(raw)), and then GA-specific (Q1-4(adj)) SCr distribution. Linear regression analysis revealed that Q1-4(adj) groups had better predictive outcomes than the Q1-4(raw) groups. In logistic regression model, the Q1-4(adj) groups exhibited a robust non-linear U-shaped relationship with the risk of adverse pregnancy outcomes, compared to the Q1-4(raw) groups. The integrative analysis on SCr with respect to GA-specific distribution could be used to screen out pregnant women with a normal SCr coupled with a decreased renal function.

Automated summary

This study reveals the relationship between serum creatinine level and adverse pregnancy outcomes, taking into account the pregnancy-related biological changes. The analysis shows that the gestational age-specific distribution of serum creatinine can be used to predict adverse pregnancy outcomes.